scholarly journals Hydrophobicity Parameters Determined by Reversed-Phase Liquid Chromatography. X. Relationship between Capacity Factor and Octanol-Water Partition Coefficients of Monosubstituted Thiophenes.

1995 ◽  
Vol 43 (12) ◽  
pp. 2238-2242 ◽  
Author(s):  
Chisako YAMAGAMI ◽  
Yuko MASAKI
Keyword(s):  
Liquid Chromatography ◽  
Partition Coefficients ◽  
Reversed Phase ◽  
Capacity Factor ◽  
Reversed Phase Liquid Chromatography ◽  
Phase Liquid

scholarly journals Correlation between retention constants obtained in reversed-phase liquid chromatography and partition coefficients of some benzimidazole derivatives

2004 ◽  
pp. 165-177 ◽  
Author(s):  
Marijana Acanski ◽  
Tatjana Djakovic-Sekulic
Keyword(s):  
Liquid Chromatography ◽  
Partition Coefficients ◽  
Reversed Phase ◽  
Benzimidazole Derivatives ◽  
Log P ◽  
Binary Solvent ◽  
Solvent Mixtures ◽  
Reversed Phase Liquid Chromatography ◽  
Phase Liquid ◽  
Phase Retention

Several calculation procedures for log P values based on the fragmental and atomic contributions are compared with experimental reversed-phase liquid chromatography (RPLC) retention constants of benzimidazole derivatives. The RPLC experiments were performed on HPLC comerrcially available LiChrosorb RP(-18 column with binary solvent mixtures of methanol-phosphate buffer (pH 7) as mobile phase. Retention constant log k0 was determined by the extrapolation method. Good correlaton was found between the retention constants log k0 and log P, as well as m and log P of the compounds investigated.

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