Characterization of Peracylated .BETA.-Cyclodextrins with Different Chain Lengths as a Novel Sustained Release Carrier for Water-Soluble Drugs.

1995 ◽  
Vol 43 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Fumitoshi HIRAYAMA ◽  
Masayuki YAMANAKA ◽  
Takashi HORIKAWA ◽  
Kaneto UEKAMA
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drugs ◽  
Chain Lengths

Polymer‐surfactant nanoparticles for sustained release of water‐soluble drugs

2007 ◽  
Vol 96 (12) ◽  
pp. 3379-3389 ◽  
Author(s):  
Mahesh D. Chavanpatil ◽  
Ayman Khdair ◽  
Yogesh Patil ◽  
Hitesh Handa ◽  
Guangzhao Mao ◽  
...  
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drugs ◽  
Polymer Surfactant

scholarly journals Characterization and Antioxidant Activity of Mahogany Bark Extract-loaded Chitosan Nanoparticles

2017 ◽  
Vol 4 (1) ◽  
pp. 94-99
Author(s):  
Syamsul Falah ◽  
Sulistiyani Sulistiyani ◽  
Dimas Andrianto
Keyword(s):  
Antioxidant Activity ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Spherical Shape ◽  
Water Soluble ◽  
Bark Extract ◽  
X Ray Diffraction ◽  
Water Soluble Drugs ◽  
Radical Method

Nanoparticles-based drug delivery has been recognized to improve the solubility of poorly water-soluble drugs, prolong the half-life of drug systematic circulation by reducing immunogenicity, and releases drugs at a sustain rate. The present study reports on the characterization of mahogany bark extract-loaded chitosan nanoparticles and their antioxidant activity.  Mahogany bark meal was extracted in boiled water for four hours.  Chitosan-sodium tripolyphosphate (STPP) nanospheres were sonicated with ultrasonicator to obtain chitosan-STTP nanocapsules for 30 and 60 min and then were dried with spray dryer. The chitosan-STPP nanocapsules loaded by mahogany extract were then analysed for surface morphology and physical state by scanning electron microscope (SEM) and X ray diffraction (XRD), respectively. Antioxidant activity of the nanoparticles was evaluated by scavenging the 1,1-diphenyl-2-picrylhydrazyl (DPPH) using free radical method. Based on SEM data, the nanoparticle shapes were viewed to adhere to spherical shape. Spherical chitosan-STTP nanoparticles loaded with mahogany bark extract were obtained in the size range of 480 ~ 2000 nm and 240 ~ 1000 nm for 30 and 60 min of ultrasonication time, respectively. The antioxidant activity of the nanoparticles was lower than that of the native mahogany bark extract. 

Sign in / Sign up

Export Citation Format

Share Document