scholarly journals Inhibitory Effects of Some Natural Products on the Activation of Hyaluronidase and Their Antiallergic Actions.

1992 ◽  
Vol 40 (6) ◽  
pp. 1439-1442 ◽  
Author(s):  
Hisao KAKEGAWA ◽  
Hitoshi MATSUMOTO ◽  
Toshio SATOH
Keyword(s):  
Natural Products ◽  
Inhibitory Effects

scholarly journals Anti-tumor Promoting Activities of Natural Products. II. Inhibitory Effects of Digitoxin on Two-Stage Carcinogenesis of Mouse Skin Tumors and Mouse Pulmonary Tumors.

1993 ◽  
Vol 16 (9) ◽  
pp. 930-931 ◽  
Author(s):  
Akira INADA ◽  
Tsutomu NAKANISHI ◽  
Takao KONOSHIMA ◽  
Mutsuo KOZUKA ◽  
Harukuni TOKUDA ◽  
...  
Keyword(s):  
Natural Products ◽  
Mouse Skin ◽  
Skin Tumors ◽  
Inhibitory Effects ◽  
Two Stage ◽  
Pulmonary Tumors

scholarly journals Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

2017 ◽  
Vol 2017 ◽  
pp. 1-24 ◽  
Author(s):  
Moon Nyeo Park ◽  
Hyo Sook Song ◽  
Myungsun Kim ◽  
Min-Jung Lee ◽  
Whisung Cho ◽  
...  
Keyword(s):  
Natural Products ◽  
Secretory Pathway ◽  
Suppressive Effect ◽  
Driver Mutations ◽  
Inhibitory Effects ◽  
Sargassum Serratifolium ◽  
Apoptosis Pathways ◽  
Key Driver ◽  
Related Pathway ◽  
Key Substances

Common care for glioblastoma multiforme (GBM) is a surgical resection followed by radiotherapy and temozolomide- (TMZ-) based chemotherapy. Unfortunately, these therapies remain inadequate involving severe mortality and recurrence. Recently, new approaches discovering combinations of multiple inhibitors have been proposed along with the identification of key driver mutations that are specific to each patient. To date, this approach is still limited by the lack of effective therapy. Hopefully, novel compounds derived from natural products are suggested as potential solutions. Inhibitory effects of natural products on angiogenesis and metastasis and cancer suppressive effect of altering miRNA expression are provident discoveries. Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways. Brazilin displays antitumor features by making influence on reactive oxygen species (ROS) intensity. Sargassum serratifolium, flavonoids, and so on have antimetastasis effect. Ficus carica controls miRNA that inhibits translation of certain secretory pathway proteins during the UPR. Serratia marcescens and patupilone (EPO 906) are physically assessed materials through clinical trials related to GBM progression. Consequently, our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathway solving pending problem such as reducing toxicity and side effect.

scholarly journals Enzyme Activity of Natural Products on Cytochrome P450

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 515
Author(s):  
Hua-Li Zuo ◽  
Hsi-Yuan Huang ◽  
Yang-Chi-Dung Lin ◽  
Xiao-Xuan Cai ◽  
Xiang-Jun Kong ◽  
...  
Keyword(s):  
Natural Products ◽  
Enzyme Activity ◽  
Cytochrome P450 ◽  
Synergistic Effects ◽  
Drug Application ◽  
Inhibitory Effects ◽  
Serious Adverse Events ◽  
Metabolizing Enzymes ◽  
Herbal Formulae ◽  
Comprehensive Compilation

Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases, play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various xenobiotic substrates, which will eventually be responsible for most metabolism-based herb–herb or herb–drug interactions, usually involving competition with another drug for the same enzyme binding site. Compounds from herbal or natural products are involved in many scenarios in the context of such interactions. These interactions are decisive both in drug discovery regarding the synergistic effects, and drug application regarding unwanted side effects. Herein, this review was conducted as a comprehensive compilation of the effects of herbal ingredients on CYP450 enzymes. Nearly 500 publications reporting botanicals’ effects on CYP450s were collected and analyzed. The countries focusing on this topic were summarized, the identified herbal ingredients affecting enzyme activity of CYP450s, as well as methods identifying the inhibitory/inducing effects were reviewed. Inhibitory effects of botanicals on CYP450 enzymes may contribute to synergistic effects, such as herbal formulae/prescriptions, or lead to therapeutic failure, or even increase concentrations of conventional medicines causing serious adverse events. Conducting this review may help in metabolism-based drug combination discovery, and in the evaluation of the safety profile of natural products used therapeutically.

scholarly journals Molecular Regulation of α3β4 Nicotinic Acetylcholine Receptors by Lupeol in Cardiovascular System

2020 ◽  
Vol 21 (12) ◽  
pp. 4329
Author(s):  
Sanung Eom ◽  
Chaelin Kim ◽  
Hye Duck Yeom ◽  
Jaeeun Lee ◽  
Shinhui Lee ◽  
...  
Keyword(s):  
Natural Products ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Animal Experiments ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Nicotinic Acetylcholine ◽  
Electrode Voltage ◽  
Treatment Of Hypertension ◽  
Nicotine Acetylcholine Receptor

Cardiovascular disease (CVD) occurs globally and has a high mortality rate. The highest risk factor for developing CVD is high blood pressure. Currently, natural products are emerging for the treatment of hypertension to avoid the side effects of drugs. Among existing natural products, lupeol is known to be effective against hypertension in animal experiments. However, there exists no study regarding the molecular physiological evidence against the effects of lupeol. Consequently, we investigated the interaction of lupeol with α3β4 nicotinic acetylcholine receptors (nAChRs). In this study, we performed a two-electrode voltage-clamp technique to investigate the effect of lupeol on the α3β4 nicotine acetylcholine receptor using the oocytes of Xenopus laevis. Coapplication of acetylcholine and lupeol inhibited the activity of α3β4 nAChRs in a concentration-dependent, voltage-independent, and reversible manner. We also conducted a mutational experiment to investigate the influence of residues of the α3 and β4 subunits on lupeol binding with nAChRs. Double mutants of α3β4 (I37A/N132A), nAChRs significantly attenuated the inhibitory effects of lupeol compared to wild-type α3β4 nAChRs. A characteristic of α3β4 nAChRs is their effect on transmission in the cardiac sympathetic ganglion. Overall, it is hypothesized that lupeol lowers hypertension by mediating its effects on α3β4 nAChRs. The interaction between lupeol and α3β4 nAChRs provides evidence against its effect on hypertension at the molecular-cell level. In conclusion, the inhibitory effect of lupeol is proposed as a novel therapeutic approach involving the antihypertensive targeting of α3β4 nAChRs. Furthermore, it is proposed that the molecular basis of the interaction between lupeol and α3β4 nAChRs would be helpful in cardiac-pharmacology research and therapeutics.

scholarly journals Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

2021 ◽  
Author(s):  
Tai Young Kim ◽  
Sangeun Jeon ◽  
Youngho Jang ◽  
Lizaveta Gotina ◽  
Joungha Won ◽  
...  
Keyword(s):  
Natural Products ◽  
Membrane Fusion ◽  
Herbal Medicines ◽  
Membrane Cholesterol ◽  
Triterpenoid Saponin ◽  
Global Public Health ◽  
Inhibitory Effects ◽  
Platycodon Grandiflorum ◽  
Platycodin D ◽  
Niemann Pick

AbstractAn ongoing pandemic of coronavirus disease 2019 (COVID-19) is now the greatest threat to global public health. Herbal medicines and their derived natural products have drawn much attention in the treatment of COVID-19, but the detailed mechanisms by which natural products inhibit SARS-CoV-2 have not been elucidated. Here, we show that platycodin D (PD), a triterpenoid saponin abundant in Platycodon grandiflorum (PG), a dietary and medicinal herb commonly used in East Asia, effectively blocks the two main SARS-CoV-2 infection routes via lysosome- and transmembrane protease serine 2 (TMPRSS2)-driven entry. Mechanistically, PD prevents host entry of SARS-CoV-2 by redistributing membrane cholesterol to prevent membrane fusion, which can be reinstated by treatment with a PD-encapsulating agent. Furthermore, the inhibitory effects of PD are recapitulated by the pharmacological inhibition or gene silencing of NPC1, which is mutated in patients with Niemann–Pick type C (NPC) displaying disrupted membrane cholesterol distribution. Finally, readily available local foods or herbal medicines containing PG root show similar inhibitory effects against SARS-CoV-2 infection. Our study proposes that PD is a potent natural product for preventing or treating COVID-19 and that briefly disrupting the distribution of membrane cholesterol is a potential novel therapeutic strategy for SARS-CoV-2 infection.

Inhibitory effects of useful extracts from natural products toward tyrosinase

2008 ◽  
Vol 136 ◽  
pp. S388
Author(s):  
Woo-Young Jang ◽  
In-Woo Bae ◽  
Kwang-Hoon Kong
Keyword(s):  
Natural Products ◽  
Inhibitory Effects
Sign in / Sign up

Export Citation Format

Share Document