scholarly journals Antitumor and immunomodulating activites of a .BETA.-glucan obtained from liquid-cultured Grifola frondosa.

1989 ◽  
Vol 37 (2) ◽  
pp. 410-413 ◽  
Author(s):  
Iwao SUZUKI ◽  
Koichi HASHIMOTO ◽  
Shozo OIKAWA ◽  
Kichiro SATO ◽  
Masumi OSAWA ◽  
...  
Keyword(s):  
Grifola Frondosa ◽  
Beta Glucan

scholarly journals Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Yu-Ri Seo ◽  
Dinesh K. Patel ◽  
Woo-Chul Shin ◽  
Wan-Sup Sim ◽  
Ok-Hwan Lee ◽  
...  
Keyword(s):  
Particle Size ◽  
Cell Activation ◽  
Cell Activity ◽  
Food Additive ◽  
Grifola Frondosa ◽  
Immunological Activity ◽  
Beta Glucan ◽  
Hypoglycemic Agent ◽  
Immune Booster ◽  
Cytokines Secretion

Beta-glucan (β-glucan) is a macromolecule structure where glucose unit has bonded through β-glycosidic bond at 1 and 3 positions. It is well known as a natural immunomodulator without exhibiting any side effects via enhancing immunity. Mushroom contains a large amount of β-glucan and it has anticancerous and antioxidant efficacy. Structure and physical properties of β-glucan are highly influenced by the types of mushroom. In particular, Grifola frondosa has β-1, 3 and β-1, 6 bonds in their structure. It has been noted that β-glucan content also depends upon the size of mushroom particles. The exact content of β-glucan and their immunological activity by a particle size of G. frondosa have yet to be fully elucidated. Herein, β-glucan contents were analyzed according to the particle size of leaf mushroom followed by cell activation and immunoactivity analysis. The highest β-glucan content was observed at a particle size of 20-30 μm (27.65 ± 0.30 w/w). All samples showed ~ 103% cell activation compared to the control and greater cell activity was observed at higher concentration. The significant increase in cytokines secretion was observed in the presence of 20-30 μm particle size of G. frondosa compared to the control. This study suggested that 20-30 μm size is the suitable size of G. frondosa that can be used as a health supplement and food additive to act as an immune booster, hypotensive agent, and hypoglycemic agent.

scholarly journals Preparation of Antibody against Antitumor .BETA.-Glucan in Grifola frondosa and Its Application.

1999 ◽  
Vol 5 (4) ◽  
pp. 398-401 ◽  
Author(s):  
Masashi MIZUNO ◽  
Akio YAMAKAWA ◽  
Ken-ichiro MINATO ◽  
Sachiko KAWAKAMI ◽  
Shigenobu TATSUOKA ◽  
...  
Keyword(s):  
Grifola Frondosa ◽  
Beta Glucan

Anticancer and Hypoglycemic Effects of Polysaccharides in Edible and Medicinal Maitake Mushroom [Grifola frondosa (Dicks.: Fr.) S. F. Gray]

2002 ◽  
Vol 4 (3) ◽  
pp. 11 ◽  
Author(s):  
Sensuke Konno ◽  
Shahrad Aynehchi ◽  
Daniele J. Dolin ◽  
Alec M. Schwartz ◽  
Muhammad S. Choudhury ◽  
...  
Keyword(s):  
Grifola Frondosa ◽  
Maitake Mushroom

ANALISA KANDUNGAN BETA-GLUKAN LARUT AIR DAN LARUT ALKALI DARI TUBUH BUAH JAMUR TIRAM (Pleurotus ostreatus) DAN SHIITAKE (Lentinus edodes)

2013 ◽  
Vol 13 (3) ◽  
Author(s):  
Netty Widyastuti ◽  
Teguh Baruji ◽  
Henky Isnawan ◽  
Priyo Wahyudi ◽  
Donowati Donowati
Keyword(s):  
Molecular Structure ◽  
Molecular Weight ◽  
Immune System ◽  
Pleurotus Ostreatus ◽  
Water Soluble ◽  
Low Molecular Weight ◽  
Lentinus Edodes ◽  
Beta Glucan ◽  
Oyster Mushrooms ◽  
The Difference

Beta glucan is a polysaccharide compound, generally not soluble inwater and resistant to acid. Beta glucan is used as an immunomodulator (enhancing the immune system) in mammals is usually a beta-glucan soluble in water, easily absorbed and has a low molecular weight. Several example of beta-glucan such as cellulose (β-1 ,4-glucan), lentinan (β-1 0.6-glucan) and (β-1 ,3-glucan), pleuran (β-1, 6 and β-1 ,3-glucan) are isolated from species of fungi Basidiomycota include mushrooms (Pleurotus ostreatus) and shiitake (Lentinus edodes).The purpose of thisresearch activity is to obtain beta-glucan compound that can be dissolved in water and in alkali derived from fungi Basidiomycota, i.e, Oyster mushrooms (Pleurotus ostreatus) and shiitake (Lentinus edodes). The result of beta-glucan compared to characterize the resulting beta glucan that is molecular structure . The difference of beta glucan extraction is based on the differences in solubility of beta-glucan. Beta glucan could be water soluble and insoluble water.

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