scholarly journals Inhibition of acyl coenzyme A: Cholesterol acyltransferase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

1989 ◽  
Vol 37 (6) ◽  
pp. 1635-1636 ◽  
Author(s):  
Fumiaki ISHIDA ◽  
Akiko SATO ◽  
Yuri IIZUKA ◽  
Toshio KAMEI
Keyword(s):  
Coenzyme A ◽  
Cholesterol Acyltransferase ◽  
Reductase Inhibitors ◽  
Acyl Coenzyme A ◽  
Coenzyme A Reductase

scholarly journals Study of the 3-Hydroxy Eicosanoyl-Coenzyme A Dehydratase and (E)-2,3 Enoyl-Coenzyme A Reductase Involved in Acyl-Coenzyme A Elongation in Etiolated Leek Seedlings

1999 ◽  
Vol 119 (3) ◽  
pp. 1009-1016 ◽  
Author(s):  
René Lessire ◽  
Sylvette Chevalier ◽  
Karine Lucet-Levannier ◽  
Jean-Paul Lellouche ◽  
Charles Mioskowski ◽  
...  
Keyword(s):  
Coenzyme A ◽  
Acyl Coenzyme A ◽  
Coenzyme A Reductase

Ontogeny of acyl-CoA: cholesterol acyltransferase in rat liver, intestine, and adipose tissue

1992 ◽  
Vol 262 (4) ◽  
pp. G599-G602
Author(s):  
M. T. Little ◽  
P. Hahn
Keyword(s):  
Adipose Tissue ◽  
Rat Liver ◽  
Animal Studies ◽  
Coenzyme A ◽  
Cholesterol Metabolism ◽  
Cholesterol Acyltransferase ◽  
Dietary Manipulation ◽  
Acat Activity ◽  
Brown Adipose ◽  
Acyl Coenzyme A

The development of acyl-coenzyme A: cholesterol acyltransferase (ACAT), was determined in the rat liver, intestine, and white (WAT) and brown adipose tissue (BAT). Animal studies have shown that dietary manipulation of cholesterol metabolism during an animal's early development can have persistent and permanent effects. Therefore it is important that the ontogeny of ACAT, one of the key enzymes in cholesterol metabolism, be clearly established. White Wistar rats were killed on day 21 of gestation, at birth, and on postnatal days 10, 14, 18, 21, 22, 25, 30, and 60. The tissues were rapidly excised, microsomes were prepared, and the activity of ACAT was measured as the rate of incorporation of [1-14C]oleoyl coenzyme A into cholesterol esters. Age-specific changes were observed in three of the four tissues investigated. Rat liver and intestine possess significant amounts of ACAT activity throughout development with marked variations in activity during this time. ACAT activity in BAT is low and variable throughout development with the exception of high activity noted in the adult animal. WAT contained little or no ACAT activity during development.

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