Enantioselective synthesis of .beta.-hydroxy .delta.-lactones: a new approach to the synthetic congeners of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

G. Bhaskar Reddy; Tatsuya Minami; Takeshi Hanamoto; Tamejiro Hiyama

doi:10.1021/jo00020a008

Enantioselective synthesis of .beta.-hydroxy .delta.-lactones: a new approach to the synthetic congeners of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

The Journal of Organic Chemistry ◽

10.1021/jo00020a008 ◽

1991 ◽

Vol 56 (20) ◽

pp. 5752-5754 ◽

Cited By ~ 29

Author(s):

G. Bhaskar Reddy ◽

Tatsuya Minami ◽

Takeshi Hanamoto ◽

Tamejiro Hiyama

Keyword(s):

Coenzyme A ◽

Enantioselective Synthesis ◽

New Approach ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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ChemInform Abstract: Enantioselective Synthesis of β-Hydroxy δ-Lactones: A New Approach to the Synthetic Congeners of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors.

ChemInform ◽

10.1002/chin.199208215 ◽

2010 ◽

Vol 23 (8) ◽

pp. no-no

Author(s):

G. B. REDDY ◽

T. MINAMI ◽

T. HANAMOTO ◽

T. HIYAMA

Keyword(s):

Coenzyme A ◽

Enantioselective Synthesis ◽

New Approach ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Sex Difference in Inhibition of In Vitro Mexazolam Metabolism by Various 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors in Rat Liver Microsomes

Drug Metabolism and Disposition ◽

10.1124/dmd.30.8.904 ◽

2002 ◽

Vol 30 (8) ◽

pp. 904-910 ◽

Cited By ~ 5

Author(s):

Michi Ishigami ◽

Wataru Takasaki ◽

Toshihiko Ikeda ◽

Toru Komai ◽

Kiyomi Ito ◽

...

Keyword(s):

Sex Difference ◽

Rat Liver ◽

Coenzyme A ◽

Liver Microsomes ◽

Rat Liver Microsomes ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors associated with elevated serum IgE and eosinophilia

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(95)70109-5 ◽

1995 ◽

Vol 95 (5) ◽

pp. 1053-1055 ◽

Cited By ~ 5

Author(s):

C FOSSO ◽

M MILLER ◽

W SOLOMON ◽

J BAKERJR

Keyword(s):

Adverse Effects ◽

Coenzyme A ◽

Elevated Serum ◽

Serum Ige ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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HMG coenzyme-A reductase inhibitors

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions ◽

10.1016/b0-44-451005-2/01014-7 ◽

2006 ◽

pp. 1632-1639

Keyword(s):

Coenzyme A ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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ChemInform Abstract: 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. Part 5. 6-(Fluoren-9-yl)- and 6-(Fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic Acids and Their Lactone Derivatives.

Chemischer Informationsdienst ◽

10.1002/chin.198638209 ◽

1986 ◽

Vol 17 (38) ◽

Author(s):

G. E. STOKKER ◽

A. W. ALBERTS ◽

J. L. GILFILLAN ◽

J. W. HUFF ◽

R. L. SMITH

Keyword(s):

Coenzyme A ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Hydroxymethylglutaryl Coenzyme a Reductase Inhibitors Differentially Modulate Plasma Fatty Acids in Rats With Diet-Induced-Hyperhomocysteinemia: Is ω-3 Fatty Acids Supplementation Necessary?

Frontiers in Physiology ◽

10.3389/fphys.2019.00892 ◽

2019 ◽

Vol 10 ◽

Author(s):

Tamara Nikolic Turnic ◽

Aleksandra Arsic ◽

Vesna Vucic ◽

Snjezana Petrovic ◽

Danijela Ristic-Medic ◽

...

Keyword(s):

Fatty Acids ◽

Coenzyme A ◽

Plasma Fatty Acids ◽

Reductase Inhibitors ◽

Hydroxymethylglutaryl Coenzyme A Reductase ◽

Coenzyme A Reductase

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Long-term Safety of Hepatic Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitors

Archives of Internal Medicine ◽

10.1001/archinte.160.15.2273 ◽

2000 ◽

Vol 160 (15) ◽

pp. 2273 ◽

Cited By ~ 85

Author(s):

Michael Bottorff ◽

Philip Hansten

Keyword(s):

Coenzyme A ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

Life Sciences ◽

10.1016/s0024-3205(99)00199-x ◽

1999 ◽

Vol 65 (13) ◽

pp. 1329-1337 ◽

Cited By ~ 68

Author(s):

Mohammed H. Moghadasian

Keyword(s):

Clinical Pharmacology ◽

Coenzyme A ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

International Journal of Clinical & Laboratory Research ◽

10.1007/bf02592449 ◽

1994 ◽

Vol 24 (3) ◽

pp. 171-176 ◽

Cited By ~ 43

Author(s):

A. M. Bargossi ◽

M. Battino ◽

A. Gaddi ◽

P. L. Fiorella ◽

G. Grossi ◽

...

Keyword(s):

Coenzyme A ◽

Reductase Inhibitors ◽

Coenzyme A Reductase

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Synergetic Effect and Structure−Activity Relationship of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors from Crataegus pinnatifida Bge.

Journal of Agricultural and Food Chemistry ◽

10.1021/jf903337f ◽

2010 ◽

Vol 58 (5) ◽

pp. 3132-3138 ◽

Cited By ~ 18

Author(s):

Xiao-Li Ye ◽

Wen-wen Huang ◽

Zhu Chen ◽

Xue-Gang Li ◽

Ping Li ◽

...

Keyword(s):

Coenzyme A ◽

Synergetic Effect ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Reductase Inhibitors ◽

Crataegus Pinnatifida ◽

Structure Activity ◽

Relationship Of ◽

Coenzyme A Reductase

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