scholarly journals Facile prepartion of unstable metabolic intermediates; Epoxide(s) of pyrazolo[1,5-a]pyridine derivatives by the cytochrome P-450 chemical model.

1989 ◽  
Vol 37 (5) ◽  
pp. 1410-1412 ◽  
Author(s):  
Yoshio NAGATSU ◽  
Tsunehiko HIGUCHI ◽  
Masaaki HIROBE
Keyword(s):  
Chemical Model ◽  
Pyridine Derivatives ◽  
Metabolic Intermediates ◽  
Cytochrome P 450

Binding of Pyridine Derivatives to Cytochrome P-450

1977 ◽  
Vol 66 (7) ◽  
pp. 1046-1047 ◽  
Author(s):  
Jerry L. Born ◽  
David Vaughn
Keyword(s):  
Pyridine Derivatives ◽  
Cytochrome P 450

Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases

1989 ◽  
pp. 99-117
Author(s):  
Daniel Mansuy ◽  
Pierrette Battioni ◽  
Jean-Paul Battioni
Keyword(s):  
Model Systems ◽  
Chemical Model ◽  
Cytochrome P 450

Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases

1989 ◽  
Vol 184 (2) ◽  
pp. 267-285 ◽  
Author(s):  
Daniel MANSUY ◽  
Pierrette BATTIONI ◽  
Jean-Paul BATTIONI
Keyword(s):  
Model Systems ◽  
Chemical Model ◽  
Cytochrome P 450

A chemical model of cytochrome P-450 with electron-transfer activity

1989 ◽  
Vol 162 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Hiromu Sakurai ◽  
Yoshihiro Mori ◽  
Masayuki Shibuya
Keyword(s):  
Electron Transfer ◽  
Chemical Model ◽  
Transfer Activity ◽  
Cytochrome P 450

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Sign in / Sign up

Export Citation Format

Share Document