A chemical model of cytochrome P-450: mono-oxygenase-like activation of dioxygen

Journal of the Chemical Society Chemical Communications ◽

10.1039/c39870000731 ◽

1987 ◽

pp. 731 ◽

Cited By ~ 36

Author(s):

Elene I. Karasevich ◽

Alexander M. Khenkin ◽

Alexander E. Shilov

Keyword(s):

Chemical Model ◽

Cytochrome P 450

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Facile prepartion of unstable metabolic intermediates; Epoxide(s) of pyrazolo[1,5-a]pyridine derivatives by the cytochrome P-450 chemical model.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.37.1410 ◽

1989 ◽

Vol 37 (5) ◽

pp. 1410-1412 ◽

Cited By ~ 11

Author(s):

Yoshio NAGATSU ◽

Tsunehiko HIGUCHI ◽

Masaaki HIROBE

Keyword(s):

Chemical Model ◽

Pyridine Derivatives ◽

Metabolic Intermediates ◽

Cytochrome P 450

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Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450.

ChemInform ◽

10.1002/chin.200301119 ◽

2003 ◽

Vol 34 (1) ◽

pp. no-no

Author(s):

Hiroyuki Miyachi ◽

Yoshio Nagatsu

Keyword(s):

Model System ◽

Chemical Model ◽

Biomimetic Oxidation ◽

Cytochrome P 450

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Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.50.1137 ◽

2002 ◽

Vol 50 (8) ◽

pp. 1137-1140 ◽

Cited By ~ 4

Author(s):

Hiroyuki Miyachi ◽

Yoshio Nagatsu

Keyword(s):

Model System ◽

Chemical Model ◽

Biomimetic Oxidation ◽

Cytochrome P 450

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Aflatoxin B1 activation to a plasmid mutagen by a chemical model of cytochrome P-450

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/0027-5107(87)90247-8 ◽

1987 ◽

Vol 176 (1) ◽

pp. 11-20 ◽

Cited By ~ 9

Author(s):

M.L. Wood ◽

J.R. Lindsay Smith ◽

R.C. Garner

Keyword(s):

Aflatoxin B1 ◽

Chemical Model ◽

Cytochrome P 450

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Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases

EJB Reviews 1989 ◽

10.1007/978-3-642-75189-9_7 ◽

1989 ◽

pp. 99-117

Author(s):

Daniel Mansuy ◽

Pierrette Battioni ◽

Jean-Paul Battioni

Keyword(s):

Model Systems ◽

Chemical Model ◽

Cytochrome P 450

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Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1989.tb15017.x ◽

1989 ◽

Vol 184 (2) ◽

pp. 267-285 ◽

Cited By ~ 137

Author(s):

Daniel MANSUY ◽

Pierrette BATTIONI ◽

Jean-Paul BATTIONI

Keyword(s):

Model Systems ◽

Chemical Model ◽

Cytochrome P 450

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A chemical model of cytochrome P-450 with electron-transfer activity

Inorganica Chimica Acta ◽

10.1016/s0020-1693(00)83113-8 ◽

1989 ◽

Vol 162 (1) ◽

pp. 23-25 ◽

Cited By ~ 7

Author(s):

Hiromu Sakurai ◽

Yoshihiro Mori ◽

Masayuki Shibuya

Keyword(s):

Electron Transfer ◽

Chemical Model ◽

Transfer Activity ◽

Cytochrome P 450

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Ultrastructure and Drug Metabolism in the Developing Guinea Pig

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100073131 ◽

1973 ◽

Vol 31 ◽

pp. 538-539

Author(s):

W. Kuenzig ◽

M. Boublik ◽

J.J. Kamm ◽

J.J. Burns

Keyword(s):

Guinea Pig ◽

Metabolic Activity ◽

Animal Species ◽

Adult Animal ◽

Smooth Endoplasmic Reticulum ◽

Fetal Life ◽

Mixed Function Oxidase ◽

Cytochrome P 450 ◽

Microsomal Mixed Function Oxidase ◽

Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

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