scholarly journals Studies on the origin, processing and quality of crude drugs. II Pharmacological evaluation of the Chinese crude drug "Zhu" in experimental stomach ulcer. 2 Inhibitory effect of extract of Atractylodes lancea on gastric secretion.

1986 ◽  
Vol 34 (9) ◽  
pp. 3854-3860 ◽  
Author(s):  
MARI NOGAMI ◽  
TOSHITSUGU MORIURA ◽  
MICHINORI KUBO ◽  
TADATO TANI
Keyword(s):  
Gastric Secretion ◽  
Inhibitory Effect ◽  
Stomach Ulcer ◽  
Pharmacological Evaluation ◽  
Atractylodes Lancea ◽  
Crude Drug ◽  
Crude Drugs

scholarly journals Evaluation of Physiochemical Screening and Standardization on the Root of Rotula aquatica Lour.

2013 ◽  
Vol 1 (01) ◽  
pp. 63-67
Author(s):  
Abhishek B. ◽  
Avinash Saini
Keyword(s):  
Moisture Content ◽  
Water Soluble ◽  
Isolation And Identification ◽  
Crude Drug ◽  
Successive Extraction ◽  
The Family ◽  
Microscopic Studies ◽  
Crude Drugs ◽  
Chloroform Methanol

The root of Rotula aquatica is also called as pashanbed, belonging to the family Borogenaceae. It is widely distributed in India from kumaun to Assam and western to southern India.The medicinal values of plant lie in their component phytochemicals such as alkaloids, flavonoids, phenolic compounds and other nutrients like as amino acid, proteins, which produce a definite physiological action on the human body. The proximate values such as moisture content, ash value, extractive value, were carried out. The dried roots powder was subjected to successive extraction with different solvents like petroleum ether, benzene, chloroform, methanol, ethanol and water. Macroscopic as well as microscopic studies of any crude drug are the primary steps to establish its botanical quality control before going to other studies. Hence Standardization of crude drug plays a very important role in identifying the purity and quality of crude drugs. The present investigation reveals Standardization which include Moisture Content, Total ash, Acid insoluble ash, Water soluble ash, Water soluble Extractive value, Alcohol soluble Extractive value, Phytochemical screening, and further isolation and identification of Phytoconstituents.

scholarly journals Variations in the Antioxidant Profile of Aegle marmoles with Drying and Solvent of Extraction

2019 ◽  
Vol 9 (3) ◽  
pp. 22-25
Author(s):  
Madhava Reddy Ch ◽  
Ganesh Kumar Y ◽  
Pranitha D ◽  
Phaneendra Pavan D
Keyword(s):  
Antioxidant Activity ◽  
Chemical Constituents ◽  
International Markets ◽  
Crude Drug ◽  
Significant Step ◽  
Massive Scale ◽  
Crude Drugs ◽  
Post Harvesting ◽  
Determining Factor

There are various processes in the crude drug processing which affects the quality of the drug in many ways. The quality of the crude drug is the determining factor that is responsible for the imports and exports of the drug to international markets. Drying is a significant step in those post-harvesting stages of the crude drug. This alone determines the microorganism contamination in the drug. Other post-harvesting methods that affect the final extract of the crude drug is the selection f solvent for extraction. The solvent selection is to be based on the parameters like the partition coefficient, the solubility of the chemical constituents. Aegle marmoles is well known for its antioxidant activity and other potential activities, and the exports of the drug were in more massive scale. To ensure the quality of the drug, the post-harvest technology of the drug was essential to determine the quality of the crude drugs. The leaves were dried in different methods and extracted with different solvents, and the investigations were done for the antioxidant activity. The results showed that the extract of the shade dried drug and the methanol solvent extracted drug showed a better phenol content and also better antioxidant activity.

scholarly journals Biologically Active Principles of Crude Drugs Pharmacological Evaluation of the Crude Drug "Zhu"

1977 ◽  
Vol 97 (8) ◽  
pp. 873-879 ◽  
Author(s):  
JOHJI YAMAHARA ◽  
TOKUNOSUKE SAWADA ◽  
TADATO TANI ◽  
TAKAO NISHINO ◽  
ISAO KITAGAWA ◽  
...  
Keyword(s):  
Biologically Active ◽  
Pharmacological Evaluation ◽  
Crude Drug ◽  
Crude Drugs

Comparative Pharmacognostic, Physicochemical and Phytochemical Studies of Different Samples of Plumbago zeylanica L. Roots

2017 ◽  
Vol 9 (06) ◽  
Author(s):  
Neha Jain ◽  
Mohan Lal Kori
Keyword(s):  
Phytochemical Analysis ◽  
Local Market ◽  
Herbal Drugs ◽  
Disease Treatment ◽  
Organoleptic Evaluation ◽  
Plumbago Zeylanica ◽  
Qualitative And Quantitative ◽  
Crude Drugs ◽  
Phytochemical Studies

The objective of the present study is to evaluate the quality of the marketed and self collected samples of Plumbago zeylanica L. roots on the standardization parameters. This study is planned mainly to confirm changes with quality of drug. Now a day’s more demand of herbal drugs for disease treatment, lack of knowledge of proper methodology and availability are promoting the practices of adulteration and substitution. Thus, the standardization of the plant crude drugs is necessary to maintain their therapeutic efficacy. Comparative studies were carried out to evaluate the standards of P. zeylanica L. with emphasis on organoleptic evaluation, physicochemical and phytochemical analysis. Samples were procured from local market and self collected to determine the qualitative and quantitative variations. The result indicates that self collected sample showed significant results with comparison to marketed sample.

Pseudo-Parkinson Disease Secondary to Ritonavir–Buspirone Interaction

2003 ◽  
Vol 37 (2) ◽  
pp. 202-205 ◽  
Author(s):  
Patrick G Clay ◽  
Molly M Adams
Keyword(s):  
Drug Interaction ◽  
Inhibitory Effect ◽  
Hiv Positive ◽  
High Dose ◽  
Resting Tremor ◽  
Case Summary ◽  
History Of ◽  
Drug Drug Interaction ◽  
To Receive

OBJECTIVE: To report a case of Parkinson-like symptoms appearing in a patient after introduction of ritonavir to buspirone therapy. CASE SUMMARY: A 54-year-old HIV-positive white man presented to the clinic with a 2-week history of ataxia, shuffling gait, cogwheel rigidity, resting tremor, and sad affect with masked features. This patient had been receiving high-dose buspirone (40 mg every morning and 30 mg every evening) for 2 years prior to the introduction of ritonavir/indinavir combination therapy (400 mg/400 mg twice daily) 6 weeks prior to initiation of the above symptoms. Buspirone was decreased to 15 mg 3 times daily, ritonavir/indinavir was discontinued, and amprenavir 1200 mg twice daily was added. The patient's symptoms began to subside after 1 week, with complete resolution after about 2 weeks. The patient continued to receive buspirone for an additional 12 months without recurrence of symptoms. DISCUSSION: This is the first reported interaction of buspirone and antiretrovirals. Buspirone, extensively metabolized by CYP3A4, was likely at supratherapeutic levels due to the inhibitory effect of ritonavir and, secondarily, indinavir. The Parkinson-like symptoms developed rapidly and severely, impacted this patient's quality of life, and necessitated significant clinic expenditures to identify this drug–drug interaction. CONCLUSIONS: This case demonstrates a severe drug–drug interaction between buspirone and ritonavir and further demonstrates the need for awareness of the metabolic profile for all agents an HIV-infected patient is receiving.

scholarly journals Application of Furcellaran Nanocomposite Film as Packaging of Cheese

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1428
Author(s):  
Agnieszka Pluta-Kubica ◽  
Ewelina Jamróz ◽  
Gohar Khachatryan ◽  
Adam Florkiewicz ◽  
Pavel Kopel
Keyword(s):  
Silver Nanoparticles ◽  
Nanocomposite Film ◽  
Microbiological Quality ◽  
Inhibitory Effect ◽  
Quality Properties ◽  
In Situ Method ◽  
And Migration ◽  
Total Bacteria

There is a serious need to develop and test new biodegradable packaging which could at least partially replace petroleum-based materials. Therefore, the objective of this work was to examine the influence of the recently developed furcellaran nanocomposite film with silver nanoparticles (obtained by an in situ method) on the quality properties of two cheese varieties: a rennet-curd (gouda) and an acid-curd (quark) cheese. The water content, physicochemical properties, microbiological and organoleptic quality of cheese, and migration of silver nanoparticles were examined. Both the number of Lactococcus and total bacteria count did not differ during storage of gouda regardless of the packaging applied. The number of Lactococcus decreased in analogous quark samples. The use of the film slowed down and inhibited the growth of yeast in gouda and quark, respectively. An inhibitory effect of this film on mold count was also observed; however, only regarding gouda. The level of silver migration was found to be lower in quark than in gouda. The film improved the microbiological quality of cheeses during storage. Consequently, it is worth continuing research for the improvement of this film in order to enable its use in everyday life.

scholarly journals Inhibitory Effect of Crude-Drug Extracts on the Degranulation of Mast Cells (RBL-2H3)

2011 ◽  
Vol 58 (7) ◽  
pp. 330-334 ◽  
Author(s):  
Mariko Asano ◽  
Megumi Dohi ◽  
Kazunaga Yazawa ◽  
Takashi Kometani ◽  
Kyoko Takahashi
Keyword(s):  
Mast Cells ◽  
Inhibitory Effect ◽  
Crude Drug
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