scholarly journals Mechanism of the intestinal absorption of drugs from oil-in-water emulsions. VII. Role of bile in the lymphatic transport of lipid-soluble compounds from triolein emulsions.

1975 ◽  
Vol 23 (4) ◽  
pp. 782-786 ◽  
Author(s):  
TETSUO NOGUCHI ◽  
YOHICHI JINGUJI ◽  
TOSHIKIRO KIMURA ◽  
SHOZO MURANISHI ◽  
HITOSHI SEZAKI
Keyword(s):  
Intestinal Absorption ◽  
Lymphatic Transport ◽  
Oil In Water

Effect of abdominal surgery on the intestinal absorption of lipophilic drugs: possible role of the lymphatic transport

2009 ◽  
Vol 153 (6) ◽  
pp. 296-300 ◽  
Author(s):  
Pavel Gershkovich ◽  
Constantin Itin ◽  
Avihai Yacovan ◽  
Shimon Amselem ◽  
Amnon Hoffman
Keyword(s):  
Abdominal Surgery ◽  
Intestinal Absorption ◽  
Lymphatic Transport ◽  
Lipophilic Drugs

scholarly journals Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe

2020 ◽  
Vol 6 (50) ◽  
pp. eabc2697
Author(s):  
Kim Pin Yeo ◽  
Hwee Ying Lim ◽  
Chung Hwee Thiam ◽  
Syaza Hazwany Azhar ◽  
Caris Tan ◽  
...  
Keyword(s):  
Lymphatic Vessels ◽  
Lymphatic Drainage ◽  
Lymphatic Transport ◽  
Atherosclerotic Plaques ◽  
Tissue Fluid ◽  
Atherosclerosis Progression ◽  
Lymphatic Vasculature ◽  
Lesion Regression ◽  
Transport Of Macromolecules

A functional lymphatic vasculature is essential for tissue fluid homeostasis, immunity, and lipid clearance. Although atherosclerosis has been linked to adventitial lymphangiogenesis, the functionality of aortic lymphatic vessels draining the diseased aorta has never been assessed and the role of lymphatic drainage in atherogenesis is not well understood. We develop a method to measure aortic lymphatic transport of macromolecules and show that it is impaired during atherosclerosis progression, whereas it is ameliorated during lesion regression induced by ezetimibe. Disruption of aortic lymph flow by lymphatic ligation promotes adventitial inflammation and development of atherosclerotic plaque in hypercholesterolemic mice and inhibits ezetimibe-induced atherosclerosis regression. Thus, progression of atherosclerotic plaques may result not only from increased entry of atherogenic factors into the arterial wall but also from reduced lymphatic clearance of these factors as a result of aortic lymph stasis. Our findings suggest that promoting lymphatic drainage might be effective for treating atherosclerosis.

scholarly journals Towards Oxidatively Stable Emulsions Containing Iron-Loaded Liposomes: The Key Role of Phospholipid-to-Iron Ratio

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1293
Author(s):  
Alime Cengiz ◽  
Karin Schroën ◽  
Claire Berton-Carabin
Keyword(s):  
Oxidative Stability ◽  
Ferrous Sulfate ◽  
Iron Concentration ◽  
Egg Yolk ◽  
Antioxidant Effect ◽  
Crucial Importance ◽  
Fortified Foods ◽  
Oil In Water ◽  
Iron Concentrations

To encapsulate soluble iron, liposomes were prepared using unsaturated phospholipids (phosphatidylcholine from egg yolk), leading to high encapsulation efficiencies (82–99%). The iron concentration affected their oxidative stability: at 0.2 and 1 mM ferrous sulfate, the liposomes were stable, whereas at higher concentrations (10 and 48 mM), phospholipid oxidation was considerably higher. When applied in oil-in-water (O/W) emulsions, emulsions with liposomes containing low iron concentrations were much more stable to lipid oxidation than those added with liposomes containing higher iron concentrations, even though the overall iron concentration was similar (0.1 M). Iron-loaded liposomes thus have an antioxidant effect at high phospholipid-to-iron ratio, but act as pro-oxidants when this ratio is too low, most likely as a result of oxidation of the phospholipids themselves. This non-monotonic effect can be of crucial importance in the design of iron-fortified foods.

Effect of soy protein and casein intake on intestinal absorption and lymphatic transport of cholesterol and oleic acid

1984 ◽  
Vol 40 (6) ◽  
pp. 1156-1164 ◽  
Author(s):  
G V Vahouny ◽  
W Chalcarz ◽  
S Satchithanandam ◽  
I Adamson ◽  
D M Klurfeld ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Intestinal Absorption ◽  
Soy Protein ◽  
Lymphatic Transport

Intestinal absorption of calcium: role of dietary phosphate and vitamin D

1981 ◽  
Vol 241 (1) ◽  
pp. G49-G53
Author(s):  
N. Brautbar ◽  
B. S. Levine ◽  
M. W. Walling ◽  
J. W. Coburn
Keyword(s):  
Vitamin D ◽  
Intestinal Absorption ◽  
Vitamin D3 ◽  
Control Groups ◽  
Dihydroxyvitamin D3 ◽  
Dietary Phosphorus ◽  
P Concentration ◽  
Dietary Phosphate ◽  
Intestinal Ca Absorption

The intestinal absorption of calcium (Ca) has been shown to depend on vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], and dietary phosphorus (P) concentration. This study was designed to evaluate the role of dietary P independent of vitamin D3 or 1,25(OH)2D3. Vitamin D-deficient rats were studied during dietary P restriction and were compared with control groups raised on a normal-phosphorus diet (NP). Balance studies were sued. Net intestinal Ca absorption was significantly lower with dietary P restriction compared with the NP group. This malabsorption of Ca was corrected by the administration of either D3 for 1,25(OH)2D3, despite hypophosphatemia. Everted gut sacs showed a marked reduction in the uptake of 45Ca in the duodenum, jejunum, and ileum during dietary P restriction. We concluded that dietary P concentration plays a major role in intestinal Ca absorption in the vitamin D-deficient rats. These findings suggest an effect of the low-phosphate diet on the vitamin D-dependent, Ca-transport mechanism.

scholarly journals Pharmaceutical approach to the oral dosage form of macromolecules: Effect of bile salts and oil-in-water emulsions on the intestinal absorption of urogastrone in the rat.

1977 ◽  
Vol 25 (8) ◽  
pp. 1974-1979 ◽  
Author(s):  
RYOHEI HORI ◽  
KATSUHIKO OKUMURA ◽  
KENICHI INUI ◽  
NOBUKUNI NAKAMURA ◽  
AKIMA MIYOSHI ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Bile Salts ◽  
Dosage Form ◽  
Oral Dosage ◽  
Oral Dosage Form ◽  
Oil In Water

Triacylglycerol and cholesterol transport during absorption of glycerol trioleate vs. glycerol trielaidate

1996 ◽  
Vol 270 (2) ◽  
pp. G268-G276
Author(s):  
T. J. Kalogeris ◽  
L. Gray ◽  
Y. Y. Yeh ◽  
P. Tso
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Intestinal Absorption ◽  
Acid Composition ◽  
Trans Fatty Acid ◽  
Cholesterol Absorption ◽  
Lymphatic Transport ◽  
Cholesterol Transport ◽  
Lipid Emulsions ◽  
Intestinal Lymph

We used conscious, chronic lymph-fistula rats to compare intestinal lymphatic transport of glycerol trioleate (TO) vs. glycerol trielaidate (TE) and to determine the effect of TO vs. TE on absorption and transport of cholesterol. Rats were implanted with intestinal lymph fistulas and duodenal cannulas and then given intraduodenal infusions of lipid emulsions containing purified TO or TE (40 mumol/h) and cholesterol (7.8 mumol/h + 2 microCi [14C]cholesterol). Lymph samples were collected at 0, 2, 4, 5, 6, 7, and 8 h after the start of lipid infusion. Lymphatic output and luminal and gut wall recovery of radioactive lipid at 8 h were quantified. Triacylglycerol (TG) fatty acid isomers did not affect lymphatic output of TG; lymph TG fatty acid composition and output reflected infusate composition. Lymphatic output of cholesterol (mass and radioactivity) did not differ between groups; luminal and gut wall recovery of [14C]cholesterol was also similar between groups. Similar lymphatic transport of TG and cholesterol between triolein- and trielaidin-infused rats was maintained for up to 16 h after the cessation of an infused lipid load. These results indicate that TO and TE are transported into lymph similarly, and that cholesterol absorption and transport are similar irrespective of whether TO or TE is the TG source. The data suggest that trans fatty acid-induced hypercholesterolemia is not due to altered intestinal absorption and transport of cholesterol.

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