scholarly journals Kinetic approach to the development in .BETA.-lactam antibiotics. II. Prodrug. I. Simultaneous determination of hetacillin and ampicillin, and its application to the stability of hetacillin in aqueous solution.

1974 ◽  
Vol 22 (10) ◽  
pp. 2434-2443 ◽  
Author(s):  
AKIRA TSUJI ◽  
TSUKINAKA YAMANA
Keyword(s):  
Aqueous Solution ◽  
Simultaneous Determination ◽  
Kinetic Approach ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
The Stability

scholarly journals Simultaneous Determination of 12 β-Lactam Antibiotics in Human Plasma by High-Performance Liquid Chromatography with UV Detection: Application to Therapeutic Drug Monitoring

2011 ◽  
Vol 55 (10) ◽  
pp. 4873-4879 ◽  
Author(s):  
Marie-Clémence Verdier ◽  
Olivier Tribut ◽  
Pierre Tattevin ◽  
Yves Le Tulzo ◽  
Christian Michelet ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Drug Monitoring ◽  
High Performance ◽  
Therapeutic Drug ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics

ABSTRACTA rapid and specific high-performance liquid chromatography method with UV detection (HPLC-UV) for the simultaneous determination of 12 beta-lactam antibiotics (amoxicillin, cefepime, cefotaxime, ceftazidime, ceftriaxone, cloxacillin, imipenem, meropenem, oxacillin, penicillin G, piperacillin, and ticarcillin) in small samples of human plasma is described. Extraction consisted of protein precipitation by acetonitrile. An Atlantis T3 analytical column with a linear gradient of acetonitrile and a pH 2 phosphoric acid solution was used for separation. Wavelength photodiode array detection was set either at 210 nm, 230 nm, or 298 nm according to the compound. This method is accurate and reproducible (coefficient of variation [CV] < 8%), allowing quantification of beta-lactam plasma levels from 5 to 250 μg/ml without interference with other common drugs. This technique is easy to use in routine therapeutic drug monitoring of beta-lactam antibiotics.

scholarly journals Simultaneous Determination of Different Antibiotic Residues in Bovine and in Porcine Kidneys by Solid-Phase Fluorescence Immunoassay

2003 ◽  
Vol 86 (2) ◽  
pp. 236-240 ◽  
Author(s):  
Lieve Okerman ◽  
Katia De Wasch ◽  
Jan Van Hoof ◽  
Walter Smedts
Keyword(s):  
Solid Phase ◽  
Kidney Tissue ◽  
Test System ◽  
Penicillin G ◽  
Fluorescence Immunoassay ◽  
Beta Lactam ◽  
Residue Detection ◽  
Beta Lactam Antibiotics ◽  
Minimal Sample

Abstract Parallux®, a solid-phase fluorescence immunoassay (SPFIA) developed for antibiotic residue detection in milk, was used for analysis of bovine and porcine kidney tissue. Four tetracyclines, 2 broad-spectrum cephalosporins, 3 beta-lactam antibiotics, and cephapirin were detected in one run after minimal sample preparation. This commercially available test system is designed as cartridges, each with a combination of 1–4 tests. One cartridge can be used to detect 4 analytes in the same sample, or 1 or 2 analytes in different samples. The cartridge with the combination tetracyclines–ceftiofur–penicillin–cephapirin was selected because tetracyclines, beta-lactam antibiotics as well as cephalosporins, are registered for oral or parenteral use in bovines and pigs in Europe. The test is qualitative and is recommended only for screening. Tetracycline, oxytetracycline, chlortetracycline, and doxycycline were easily detected at 300 ppb with the tetracyclines channel; ceftiofur at 1000 ppb and cefquinome at 200 ppb with the ceftiofur channel; penicillin G, ampicillin, and amoxicillin at 50 ppb with the penicillin channel; and cephapirin at 100 ppb with the cephapirin channel. These levels are equal to or lower than the corresponding maximal residue limits in kidney tissue. Cephalexin was not detected. The SPFIA test can be used as an alternative to classical inhibition tests and for post-screening inhibitor- positive kidneys, because it detects 3 specific groups of antibiotics, which enables selection of specific confirmatory methods for identification and quantification.

Facile fabrication of cauliflower-like MIL-100(Cr) and its simultaneous determination of Cd2+, Pb2+, Cu2+ and Hg2+ from aqueous solution

2015 ◽  
Vol 216 ◽  
pp. 504-510 ◽  
Author(s):  
Dongfang Wang ◽  
Yingchang Ke ◽  
Di Guo ◽  
Hongxu Guo ◽  
Jianhua Chen ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Simultaneous Determination ◽  
Facile Fabrication

scholarly journals Determination of the protonation state of [H3PW11O39]4− and the stability constant of [Ag(H2O)(H3PW11O39)]3− in aqueous solution

2016 ◽  
Vol 69 (17) ◽  
pp. 2525-2531 ◽  
Author(s):  
Jidan Wang ◽  
Jiansheng Li ◽  
Wansheng You ◽  
Chunxiang He ◽  
Zaiming Zhu
Keyword(s):  
Aqueous Solution ◽  
Stability Constant ◽  
Protonation State ◽  
The Stability
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