scholarly journals Structure-Activity Correlations between Hydroxamic Acids and Their Inhibitory Powers on Urease Activity. I. A Quantitative Approach to the Effect of Hydrophobic Character of Acyl Residue

1972 ◽  
Vol 20 (8) ◽  
pp. 1599-1606 ◽  
Author(s):  
KENJI KUMAKI ◽  
SUIICHI TOMIOKA ◽  
KYOICHI KOBASHI ◽  
JUNICHI HASE
Keyword(s):  
Urease Activity ◽  
Hydroxamic Acids ◽  
Quantitative Approach ◽  
Acyl Residue ◽  
Hydrophobic Character ◽  
Structure Activity

Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids.

1992 ◽  
Vol 40 (10) ◽  
pp. 2764-2768 ◽  
Author(s):  
Shinjiro ODAKE ◽  
Kazuaki NAKAHASHI ◽  
Tadanori MORIKAWA ◽  
Sachiko TAKEBE ◽  
Kyoichi KOBASHI
Keyword(s):  
Urease Activity ◽  
Hydroxamic Acids

Effect of hydroxamic acids on growth and urease activity in Corynebacterium renale

1976 ◽  
Vol 22 (4) ◽  
pp. 544-551 ◽  
Author(s):  
Robert M. Nervig ◽  
Solomon Kadis
Keyword(s):  
Urease Activity ◽  
Hydroxamic Acids ◽  
Terminal Group ◽  
Side Chain ◽  
Acetohydroxamic Acid ◽  
Maximal Growth ◽  
Maximal Inhibition ◽  
Intact Cells ◽  
Lag Period ◽  
The Common

Studies were conducted on the effect of four different hydroxamic acids (HA), hydroxyurea, acetohydroxamic acid, p-fluorobenzoylhydroxamic acid and sorbylhydroxamic acid, on the growth and urease activity of Corynebacterium renale. The addition of each of these HA, at concentrations ranging from 10−3 to 10−5 M, to medium containing urea as the sole nitrogen source resulted in a lengthened lag period of growth the extent of which depended upon the concentration of each HA tested as well as the structure of the compound; that is, the size and (or) complexity of the side chain attached to the common terminal group of the molecule. However, the maximal growth levels achieved following conclusion of the exponential phase were not affected by the HA. Investigations on the effect of these HA on the urease activity of intact cells as well as cell-free extracts revealed that in each case the enzymatic activity was inhibited by each of the HA tested. The extent of inhibition with the intact cells was about one-half of that observed with cell-free extracts. Direct incubation of cell-free extracts as well as intact cells with each of the HA tested was required for maximal inhibition.

Synthesis and structure–Activity relationships of 5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-based hydroxamic acids as HB-EGF shedding inhibitors

2003 ◽  
Vol 11 (3) ◽  
pp. 433-450 ◽  
Author(s):  
Kazuya Yoshiizumi ◽  
Minoru Yamamoto ◽  
Tomohiro Miyasaka ◽  
Yasuko Ito ◽  
Hiroshi Kumihara ◽  
...  
Keyword(s):  
Hydroxamic Acids ◽  
Structure Activity Relationships ◽  
Structure Activity
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