Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. IV. Induction of anti-inflammatory activity by chemical cleavage of interchain disulfide bonds in human immunoglobulin G and pharmacological activity of alkylated subfragments.

TSUTOMU MIMURA; KAZUTAKE TSUJIKAWA; HIROSHI NAKAJIMA; MASARU OKABE; YASUHIRO KOHAMA; MASAKAZU IWAI; KAZUMASA YOKOYAMA

doi:10.1248/bpb1978.9.46

Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. IV. Induction of anti-inflammatory activity by chemical cleavage of interchain disulfide bonds in human immunoglobulin G and pharmacological activity of alkylated subfragments.

Journal of Pharmacobio-Dynamics ◽

10.1248/bpb1978.9.46 ◽

1986 ◽

Vol 9 (1) ◽

pp. 46-54

Author(s):

TSUTOMU MIMURA ◽

KAZUTAKE TSUJIKAWA ◽

HIROSHI NAKAJIMA ◽

MASARU OKABE ◽

YASUHIRO KOHAMA ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Pharmacological Activity ◽

Immunoglobulin G ◽

Disulfide Bonds ◽

Human Immunoglobulin ◽

Inflammatory Activity ◽

Serum Immunoglobulin ◽

Chemical Cleavage ◽

Human Immunoglobulin G

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Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. IX. Anti-inflammatory Activity of Completely Alkylated Heavy Chain (C.Fr.I-H).

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.16.309 ◽

1993 ◽

Vol 16 (3) ◽

pp. 309-311

Author(s):

Tsutomu MIMURA ◽

Masaaki ITOH ◽

Munetada HARUYAMA ◽

Tetsuya SUGIYAMA ◽

Nobutaka SUZUKI ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Heavy Chain ◽

Immunoglobulin G ◽

Inflammatory Activity ◽

Serum Immunoglobulin ◽

Anti Inflammatory

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Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/lJ Mice.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.17.623 ◽

1994 ◽

Vol 17 (5) ◽

pp. 623-626

Author(s):

Tsutomu MIMURA ◽

Masaaki ITOH ◽

Hiroko GOHGI ◽

Nobutaka SUZUKI ◽

Katsuyoshi TAKEUCHI ◽

...

Keyword(s):

Chemical Modification ◽

Immunoglobulin G ◽

Type Ii Collagen ◽

Human Immunoglobulin ◽

Type Ii ◽

Collagen Induced Arthritis ◽

Fc Fragment ◽

Human Immunoglobulin G

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Studies on pharmacological activation of human serum immunoglobulin G(IgG) by chemical modification and active subfragments. VI. Anti-allergic activity of carboxamidemethylated Fc(CM-Fc) fragment from human serum IgG.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.35.4935 ◽

1987 ◽

Vol 35 (12) ◽

pp. 4935-4939

Author(s):

TSUTOMU MIMURA ◽

SUSUMU ITOH ◽

KAZUTAKE TSUJIKAWA ◽

HIROSHI NAKAJIMA ◽

YASUHIRO KOHAMA ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Immunoglobulin G ◽

Serum Immunoglobulin ◽

Fc Fragment ◽

Serum Igg

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Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. III. Mechanism of anti-ulcerous action of alkylated light chain (Fr.I-L).

Journal of Pharmacobio-Dynamics ◽

10.1248/bpb1978.7.718 ◽

1984 ◽

Vol 7 (10) ◽

pp. 718-727

Author(s):

TSUTOMU MIMURA ◽

MASAKAZU IWAI ◽

KAZUHIRO MAEDA ◽

ISAO KOHDA ◽

KAZUTAKE TSUJIKAWA ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Light Chain ◽

Immunoglobulin G ◽

Serum Immunoglobulin

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Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. VIII. Effect of carboxamide-methylated light chain (Fr.I-L) on leukocyte functions.

Journal of Pharmacobio-Dynamics ◽

10.1248/bpb1978.12.159 ◽

1989 ◽

Vol 12 (3) ◽

pp. 159-163

Author(s):

Tsutomu MIMURA ◽

Kazutake TSUJIKAWA ◽

Naohiro YASUDA ◽

Hiroshi NAKAJIMA ◽

Byoung Gag LEE ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Light Chain ◽

Immunoglobulin G ◽

Serum Immunoglobulin

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Effect of Chemical Modification of Lysine Residues on the Conformation of Human Immunoglobulin G

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)44816-3 ◽

1972 ◽

Vol 247 (18) ◽

pp. 5703-5708

Author(s):

Yasushi Nakagawa ◽

Sylvia Capetillo ◽

Bruno Jirgensons

Keyword(s):

Chemical Modification ◽

Immunoglobulin G ◽

Human Immunoglobulin ◽

Human Immunoglobulin G ◽

Lysine Residues

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Studies on pharmacological activation of human serum IgG by chemical modification and active subfragments. I. Induction of anti-ulcerogenic activity by chemical cleavage of interchain disulfide bonds in human IgG and properties of active subfragments.

Journal of Pharmacobio-Dynamics ◽

10.1248/bpb1978.6.397 ◽

1983 ◽

Vol 6 (6) ◽

pp. 397-407

Author(s):

TSUTOMU MIMURA ◽

TAICHIRO TERADA ◽

MASAKAZU IWAI ◽

ISAO KOHDA ◽

SETSUYO TAKE ◽

...

Keyword(s):

Chemical Modification ◽

Human Serum ◽

Disulfide Bonds ◽

Human Igg ◽

Chemical Cleavage ◽

Serum Igg ◽

Ulcerogenic Activity

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Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. X. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Delayed Type Hypersensitivity.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.16.858 ◽

1993 ◽

Vol 16 (9) ◽

pp. 858-860

Author(s):

Tsutomu MIMURA ◽

Masaaki ITOH ◽

Tetsuya SUGIYAMA ◽

Nobutaka SUZUKI ◽

Tsuyoshi NAKANISHI ◽

...

Keyword(s):

Chemical Modification ◽

Immunoglobulin G ◽

Human Immunoglobulin ◽

Delayed Type Hypersensitivity ◽

Fc Fragment ◽

Human Immunoglobulin G

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A Synthetic Mimic of Human Fc Receptors: Defined Chemical Modification of Cell Surfaces Enables Efficient Endocytic Uptake of Human Immunoglobulin-G

Journal of the American Chemical Society ◽

10.1021/ja062377w ◽

2006 ◽

Vol 128 (35) ◽

pp. 11463-11470 ◽

Cited By ~ 42

Author(s):

Siwarutt Boonyarattanakalin ◽

Scott E. Martin ◽

Qi Sun ◽

Blake R. Peterson

Keyword(s):

Chemical Modification ◽

Immunoglobulin G ◽

Fc Receptors ◽

Human Immunoglobulin ◽

Cell Surfaces ◽

Human Immunoglobulin G

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Fc fragment of human immunoglobulin G: Reduction and carboxymethylation of inter-chain disulfide bonds enhances complement activating capacity

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(77)91436-x ◽

1977 ◽

Vol 78 (4) ◽

pp. 1319-1326 ◽

Cited By ~ 5

Author(s):

JoséA. Lopez de Castro ◽

Fernando Vivanco ◽

Fernando Ortiz

Keyword(s):

Immunoglobulin G ◽

Disulfide Bonds ◽

Human Immunoglobulin ◽

Fc Fragment ◽

Human Immunoglobulin G

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