scholarly journals Chronic effects of a .BETA.-adrenoceptor blocking drug, 4-(3-(tert-butylamino)-2-hydroxypropoxy)-N-methylisocarbostyril hydrochloride (N-696), in hypertensive rats.

1985 ◽  
Vol 8 (2) ◽  
pp. 134-141 ◽  
Author(s):  
NOBUTOSHI KUBOTA ◽  
KOICHIRO KISHI ◽  
HIROFUMI SOKABE ◽  
KOICHIRO KAWASHIMA ◽  
YOSHITAMI ISHII ◽  
...  
Keyword(s):  
Blocking Drug ◽  
Hypertensive Rats ◽  
Beta Adrenoceptor ◽  
Chronic Effects

Acute and Chronic Effects of Exercise on Baroreflexes in Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 714-719 ◽  
Author(s):  
Gustavo José Justo Silva ◽  
Patricia Chakur Brum ◽  
Carlos Eduardo Negrão ◽  
Eduardo Moacyr Krieger
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Chronic Effects ◽  
Acute And Chronic Effects

Analysis of beta-adrenoceptors mediating renin release produced by isoproterenol in conscious dogs

1980 ◽  
Vol 238 (5) ◽  
pp. F387-F393
Author(s):  
N. Himori ◽  
A. Izumi ◽  
T. Ishimori
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Dose ◽  
Plasma Renin ◽  
Conscious Dogs ◽  
Renin Release ◽  
Blocking Drug ◽  
Beta Adrenoceptors ◽  
Beta Adrenoceptor ◽  
Beta 2

Types of beta-adrenoceptors mediating renin release induced by isoproterenol were investigated in conscious dogs. The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram . kg-1 . 20 min-1). d-Propranolol and d-D-32 did not inhibit these three responses to isoproterenol. The selective beta 1-adrenoceptor blocking drug atenolol, at the oral dose of 6 mg/kg, which selectively suppressed isoproterenol-induced tachycardia, significantly inhibited the renin release caused by isoproterenol. By contrast, the renin release induced by isoproterenol was not modified by the selective beta 2-adrenoceptor blocking drug IPS-339 at an oral dose of 3 mg/kg, which fully and selectively antagonized the fall of blood pressure in response to isoproterenol. There was good correlation between suppression of isoproterenol-induced renin release and that of isoproterenol-induced tachycardia after various beta-adrenoceptor blocking drugs. These results lead to the conclusion that in conscious dogs the beta-adrenoceptors mediating release are mainly of the beta 1 type.

Pamatolol: Phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug

1978 ◽  
Vol 24 (2) ◽  
pp. 168-174 ◽  
Author(s):  
S. George Carruthers ◽  
James P. Hosler ◽  
Pertti Pentikainen ◽  
Daniel L. Azarnoff
Keyword(s):  
Phase I ◽  
Blocking Drug ◽  
Beta Adrenoceptor
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