Study of Prejunctional Beta-Adrenoceptors in Kidneys of Normotensive and Hypertensive Rats Using the New Beta-Adrenoceptor Blocking Drug Tertatolol

1986 ◽  
Vol 6 (2) ◽  
pp. 30-35 ◽  
Author(s):  
Tony J. Verbeuren ◽  
Arnold G. Herman
Keyword(s):  
Blocking Drug ◽  
Hypertensive Rats ◽  
Beta Adrenoceptors ◽  
Beta Adrenoceptor

Analysis of beta-adrenoceptors mediating renin release produced by isoproterenol in conscious dogs

1980 ◽  
Vol 238 (5) ◽  
pp. F387-F393
Author(s):  
N. Himori ◽  
A. Izumi ◽  
T. Ishimori
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Dose ◽  
Plasma Renin ◽  
Conscious Dogs ◽  
Renin Release ◽  
Blocking Drug ◽  
Beta Adrenoceptors ◽  
Beta Adrenoceptor ◽  
Beta 2

Types of beta-adrenoceptors mediating renin release induced by isoproterenol were investigated in conscious dogs. The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram . kg-1 . 20 min-1). d-Propranolol and d-D-32 did not inhibit these three responses to isoproterenol. The selective beta 1-adrenoceptor blocking drug atenolol, at the oral dose of 6 mg/kg, which selectively suppressed isoproterenol-induced tachycardia, significantly inhibited the renin release caused by isoproterenol. By contrast, the renin release induced by isoproterenol was not modified by the selective beta 2-adrenoceptor blocking drug IPS-339 at an oral dose of 3 mg/kg, which fully and selectively antagonized the fall of blood pressure in response to isoproterenol. There was good correlation between suppression of isoproterenol-induced renin release and that of isoproterenol-induced tachycardia after various beta-adrenoceptor blocking drugs. These results lead to the conclusion that in conscious dogs the beta-adrenoceptors mediating release are mainly of the beta 1 type.

scholarly journals Chronic effects of a .BETA.-adrenoceptor blocking drug, 4-(3-(tert-butylamino)-2-hydroxypropoxy)-N-methylisocarbostyril hydrochloride (N-696), in hypertensive rats.

1985 ◽  
Vol 8 (2) ◽  
pp. 134-141 ◽  
Author(s):  
NOBUTOSHI KUBOTA ◽  
KOICHIRO KISHI ◽  
HIROFUMI SOKABE ◽  
KOICHIRO KAWASHIMA ◽  
YOSHITAMI ISHII ◽  
...  
Keyword(s):  
Blocking Drug ◽  
Hypertensive Rats ◽  
Beta Adrenoceptor ◽  
Chronic Effects

Cardiac function and responsiveness to beta-adrenoceptor agonists in rats with obstructive jaundice

1993 ◽  
Vol 265 (2) ◽  
pp. G314-G320 ◽  
Author(s):  
G. Jacob ◽  
N. Nassar ◽  
G. Hayam ◽  
S. Ben-Haim ◽  
Y. Edoute ◽  
...  
Keyword(s):  
Bile Duct ◽  
Obstructive Jaundice ◽  
Cardiac Function ◽  
Radioligand Binding ◽  
Beta Adrenoceptors ◽  
Beta Adrenoceptor ◽  
Pithed Rats ◽  
Duct Ligation ◽  
Adrenoceptor Agonists ◽  
Beta Adrenoceptor Agonists

The function and role of the heart and the contribution of cardiac beta-adrenoceptors in the pathogenesis of circulatory failure in obstructive jaundice were studied in the 3-day bile duct-ligated (BDL) rat using three different techniques to measure cardiac function and beta-adrenoceptor activity, number, and affinity. The techniques were the pithed rat preparation, the isolated working heart preparation, and a competitive radioligand binding assay for beta-adrenoceptors. The results of these experiments were compared with those obtained in 3-day bile duct-manipulated (sham operated; SO) rats. Impaired indexes of basal cardiac contractility were observed in the BDL pithed rats and isolated working hearts. In these two preparations, responsiveness to norepinephrine and the beta-adrenoceptor agonists, isoproterenol and dobutamine, was unaffected by bile duct ligation. The affinity and number of cardiac beta-adrenoceptors in membranes from the hearts of SO and BDL rats were not significantly different from each other. These experiments have established for the first time that the 3-day BDL rat has a cardiac myopathy associated with intact responsiveness to beta-adrenoceptor agonists, a normal unchanged affinity and number of cardiac beta-adrenoceptors.

Pamatolol: Phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug

1978 ◽  
Vol 24 (2) ◽  
pp. 168-174 ◽  
Author(s):  
S. George Carruthers ◽  
James P. Hosler ◽  
Pertti Pentikainen ◽  
Daniel L. Azarnoff
Keyword(s):  
Phase I ◽  
Blocking Drug ◽  
Beta Adrenoceptor
Sign in / Sign up

Export Citation Format

Share Document