scholarly journals Biochemical studies on cachexy due to cancer. V. A hypoalbuminemic substance from Ehrlich ascites carcinoma cells.

1979 ◽  
Vol 2 (5) ◽  
pp. 295-305
Author(s):  
HIROSHI UEKI ◽  
MASAHIKO TANAKA ◽  
KATSUHIKO MORIMOTO ◽  
SHOZO SHOJI ◽  
TAKAYUKI FUNAKOSHI ◽  
...  
Keyword(s):  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Ehrlich Ascites ◽  
Biochemical Studies

BIOCHEMICAL STUDIES ON 1-AMINOCYCLOPENTANE CARBOXYLIC ACID

1962 ◽  
Vol 40 (1) ◽  
pp. 1101-1110 ◽  
Author(s):  
K. Ahmed ◽  
P. G. Scholefield
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Brain Cortex ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Inhibitory Effects ◽  
Synthetic Amino Acid ◽  
Ehrlich Ascites ◽  
Biochemical Studies

The synthetic amino acid 1-aminocyclopentane carboxylic acid does not seem to be metabolized but is actively concentrated by slices of rat brain cortex and Ehrlich ascites carcinoma cells. Its transport into the ascites cells has much in common with that of methionine since they are both inhibited by similar groups of amino acids. Kinetic analysis of the inhibitory effects of glycine, D- and L-methionine, allyl glycine, and thienyl glycine on the transport of 1-aminocyclopentane carboxylic acid confirms the suggestion that this amino acid and methionine enter ascites cells as the result of the action of a common transport system.

BIOCHEMICAL STUDIES ON 1-AMINOCYCLOPENTANE CARBOXYLIC ACID

1962 ◽  
Vol 40 (8) ◽  
pp. 1101-1110 ◽  
Author(s):  
K. Ahmed ◽  
P. G. Scholefield
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Brain Cortex ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Inhibitory Effects ◽  
Synthetic Amino Acid ◽  
Ehrlich Ascites ◽  
Biochemical Studies

The synthetic amino acid 1-aminocyclopentane carboxylic acid does not seem to be metabolized but is actively concentrated by slices of rat brain cortex and Ehrlich ascites carcinoma cells. Its transport into the ascites cells has much in common with that of methionine since they are both inhibited by similar groups of amino acids. Kinetic analysis of the inhibitory effects of glycine, D- and L-methionine, allyl glycine, and thienyl glycine on the transport of 1-aminocyclopentane carboxylic acid confirms the suggestion that this amino acid and methionine enter ascites cells as the result of the action of a common transport system.

Trichosanthes dioica seed lectin inhibits Ehrlich ascites carcinoma cells growth in vivo in mice by inducing G 0 /G 1 cell cycle arrest

2021 ◽  
Author(s):  
Shaikh Shohidul Islam ◽  
Md. Rezaul Karim ◽  
A. K. M. Asaduzzaman ◽  
A. H. M. Khurshid Alam ◽  
Zahid Hayat Mahmud ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Ehrlich Ascites ◽  
Trichosanthes Dioica

STUDIES ON THE BIOSYNTHESIS OF NUCLEOTIDES IN EHRLICH ASCITES CARCINOMA CELLS IN VITRO

1965 ◽  
Vol 43 (2) ◽  
pp. 209-224 ◽  
Author(s):  
B. I. Uppin ◽  
P. G. Scholefield
Keyword(s):  
Exchange Reaction ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
The Other ◽  
Metabolic Inhibitors ◽  
Ehrlich Ascites ◽  
Oxidative Pathway ◽  
Time Courses ◽  
Oxidation Of Glucose

Studies have been made of the effects of metabolic inhibitors on the oxidation and incorporation of radioactivity into nucleotides of glucose labelled in the 1, 2, and 6 positions. The results indicate that in Ehrlich ascites carcinoma cells the predominant oxidative pathway is the hexosemonophosphate shunt. Investigation of the time courses of oxidation of the labelled glucose molecules confirms this conclusion. The pattern of incorporation of radioactivity initially suggests that nucleotide ribose is not formed via this pathway. However, it is shown that the coupling of an active transketolase system with the other enzymes of the hexosemonophosphate shunt provides a sufficient explanation of all the experimental observations. The conclusion is reached that pentose is formed by oxidation of glucose through the shunt but that the labelling pattern is largely established as the result of the exchange reaction catalyzed by transketolase.

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