scholarly journals Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic Monophosphorothioate Rp-Isomer as a Potent Inhibitor of Protein Kinase G1α

2017 ◽  
Vol 40 (3) ◽  
pp. 365-374 ◽  
Author(s):  
Khandaker Ahtesham Ahmed ◽  
Tianli Zhang ◽  
Katsuhiko Ono ◽  
Hiroyasu Tsutsuki ◽  
Tomoaki Ida ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Potent Inhibitor ◽  
Synthesis And Characterization

Abstract 3765: Discovery and biological characterization of CX-8184, a potent inhibitor of protein kinase CK2

2012 ◽  
Author(s):  
Denis Drygin ◽  
Joshua Bliesath ◽  
Nanni Huser ◽  
Chris Proffitt ◽  
Adam Siddiqui-Jain ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Potent Inhibitor ◽  
Biological Characterization ◽  
Kinase Ck2

Synthesis and characterization of phosphocitric acid, a potent inhibitor of hydroxylapatite crystal growth

Biochemistry ◽  
1980 ◽  
Vol 19 (9) ◽  
pp. 1983-1988 ◽  
Author(s):  
W. P. Tew ◽  
C. Mahle ◽  
J. Benavides ◽  
J. E. Howard ◽  
A. L. Lehninger
Keyword(s):  
Crystal Growth ◽  
Potent Inhibitor ◽  
Synthesis And Characterization

Synthesis and Characterization of New Photolabile Phorbol Esters for Affinity Labeling of Protein Kinase C

1996 ◽  
Vol 61 (6) ◽  
pp. 2164-2173 ◽  
Author(s):  
Kazuhiro Irie ◽  
Takashi Ishii ◽  
Hajime Ohigashi ◽  
Paul A. Wender ◽  
Benjamin L. Miller ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Esters ◽  
Synthesis And Characterization ◽  
Affinity Labeling ◽  
Kinase C

scholarly journals Synthesis and Characterization of the First Potent Inhibitor of Yapsin 1

2002 ◽  
Vol 278 (8) ◽  
pp. 5523-5530 ◽  
Author(s):  
Niamh X. Cawley ◽  
Masao Chino ◽  
Alex Maldonado ◽  
Yazmin M. Rodriguez ◽  
Y. Peng Loh ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Synthesis And Characterization

scholarly journals Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

2012 ◽  
Vol 8 ◽  
pp. 841-849 ◽  
Author(s):  
Chao Che ◽  
Song Li ◽  
Bo Yang ◽  
Shengchang Xin ◽  
Zhixiong Yu ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Structure Activity Relationship ◽  
Hedgehog Pathway ◽  
Activity Relationship ◽  
Synthesis And Characterization ◽  
Important Class ◽  
Diversity Oriented Synthesis ◽  
Structure Activity ◽  
Relationship Of

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.

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