scholarly journals Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

2012 ◽  
Vol 8 ◽  
pp. 841-849 ◽  
Author(s):  
Chao Che ◽  
Song Li ◽  
Bo Yang ◽  
Shengchang Xin ◽  
Zhixiong Yu ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Structure Activity Relationship ◽  
Hedgehog Pathway ◽  
Activity Relationship ◽  
Synthesis And Characterization ◽  
Important Class ◽  
Diversity Oriented Synthesis ◽  
Structure Activity ◽  
Relationship Of

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.

scholarly journals Synthesis and characterization of photoaffinity labelling reagents towards the Hsp90 C-terminal domain

2017 ◽  
Vol 15 (7) ◽  
pp. 1597-1605 ◽  
Author(s):  
Binto Simon ◽  
Xuexia Huang ◽  
Huangxian Ju ◽  
Guoxuan Sun ◽  
Min Yang
Keyword(s):  
Binding Pocket ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Synthesis And Characterization ◽  
Photoaffinity Labelling ◽  
Terminal Domain ◽  
Structure Activity

The synthesis of diazirine type photoaffinity labelling reagents to probe the Hsp90 C-terminal domain binding pocket and the structure–activity relationship. The structure illustrates probe positions only.

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