scholarly journals Ursolic Acid from Oldenlandia diffusa Induces Apoptosis via Activation of Caspases and Phosphorylation of Glycogen Synthase Kinase 3 Beta in SK-OV-3 Ovarian Cancer Cells

2012 ◽  
Vol 35 (7) ◽  
pp. 1022-1028 ◽  
Author(s):  
Young-Hoon Song ◽  
Soo-Jin Jeong ◽  
Hee-Young Kwon ◽  
Bonglee Kim ◽  
Sung-Hoon Kim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Ovarian Cancer Cells ◽  
Oldenlandia Diffusa

scholarly journals Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth

2011 ◽  
pp. 1 ◽  
Author(s):  
Tyvette S. Hilliard ◽  
Irina N. Gaisina ◽  
Amanda G. Muehlbauer ◽  
Arsen M. Gaisin ◽  
Franck Gallier ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Ovarian Cancer Cells ◽  
Glycogen Synthase Kinase 3Β

scholarly journals Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells

2013 ◽  
Vol 42 (5) ◽  
pp. 2988-2998 ◽  
Author(s):  
Xiaoli Tang ◽  
Dong Zheng ◽  
Ping Hu ◽  
Zongyue Zeng ◽  
Ming Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cancer Tissue ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Ags Cells ◽  
Cell Functions

Abstract Glycogen synthase kinase 3 beta (GSK3β) is a critical protein kinase that phosphorylates numerous proteins in cells and thereby impacts multiple pathways including the β-Catenin/TCF/LEF-1 pathway. MicroRNAs (miRs) are a class of noncoding small RNAs of ∼22 nucleotides in length. Both GSK3β and miR play myriad roles in cell functions including stem cell development, apoptosis, embryogenesis and tumorigenesis. Here we show that GSK3β inhibits the expression of miR-96, miR-182 and miR-183 through the β-Catenin/TCF/LEF-1 pathway. Knockout of GSK3β in mouse embryonic fibroblast cells increases expression of miR-96, miR-182 and miR-183, coinciding with increases in the protein level and nuclear translocation of β-Catenin. In addition, overexpression of β-Catenin enhances the expression of miR-96, miR-182 and miR-183 in human gastric cancer AGS cells. GSK3β protein levels are decreased in human gastric cancer tissue compared with surrounding normal gastric tissue, coinciding with increases of β-Catenin protein, miR-96, miR-182, miR-183 and primary miR-183-96-182 cluster (pri-miR-183). Furthermore, suppression of miR-183-96-182 cluster with miRCURY LNA miR inhibitors decreases the proliferation and migration of AGS cells. Knockdown of GSK3β with siRNA increases the proliferation of AGS cells. Mechanistically, we show that β-Catenin/TCF/LEF-1 binds to the promoter of miR-183-96-182 cluster gene and thereby activates the transcription of the cluster. In summary, our findings identify a novel role for GSK3β in the regulation of miR-183-96-182 biogenesis through β-Catenin/TCF/LEF-1 pathway in gastric cancer cells.

scholarly journals Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41102 ◽  
Author(s):  
Shadi Mamaghani ◽  
Craig D. Simpson ◽  
Pinjiang M. Cao ◽  
May Cheung ◽  
Sue Chow ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis

scholarly journals Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer

2016 ◽  
pp. 1225
Author(s):  
Yang Zhao ◽  
Shuo Chen ◽  
Kai-Xuan Sun ◽  
Miao-Xiao Feng ◽  
Bo-Liang Liu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3

scholarly journals CG0009, a Novel Glycogen Synthase Kinase 3 Inhibitor, Induces Cell Death through Cyclin D1 Depletion in Breast Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60383 ◽  
Author(s):  
Hyun Mi Kim ◽  
Choung-Soo Kim ◽  
Je-Hwan Lee ◽  
Se Jin Jang ◽  
Jung Jin Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3
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