Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

I-Chang Chang; Yu-Jen Huang; Tsay-I Chiang; Chi-Wei Yeh; Li-Sung Hsu

doi:10.1248/bpb.33.816

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.33.816 ◽

2010 ◽

Vol 33 (5) ◽

pp. 816-824 ◽

Cited By ~ 62

Author(s):

I-Chang Chang ◽

Yu-Jen Huang ◽

Tsay-I Chiang ◽

Chi-Wei Yeh ◽

Li-Sung Hsu

Keyword(s):

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Oxygen Species ◽

Osteosarcoma Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase Pathway

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Photobiomodulation with red light-emitting diodes accelerates hepatocyte proliferation through reactive oxygen species/extracellular signal-regulated kinase pathway

Hepatology Research ◽

10.1111/hepr.13182 ◽

2018 ◽

Vol 48 (11) ◽

pp. 926-936 ◽

Cited By ~ 2

Author(s):

Rui Feng ◽

Yuji Morine ◽

Tetsuya Ikemoto ◽

Satoru Imura ◽

Shuichi Iwahashi ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Light Emitting Diodes ◽

Red Light ◽

Reactive Oxygen ◽

Hepatocyte Proliferation ◽

Oxygen Species ◽

Light Emitting ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase Pathway

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Involvement of the extracellular signal regulated kinase pathway in hydrocarbon-induced reactive oxygen species formation in human neutrophil granulocytes

Toxicology and Applied Pharmacology ◽

10.1016/s0041-008x(03)00158-3 ◽

2003 ◽

Vol 190 (2) ◽

pp. 102-110 ◽

Cited By ~ 24

Author(s):

Anne Dreiem ◽

Oddvar Myhre ◽

Frode Fonnum

Keyword(s):

Reactive Oxygen Species ◽

Human Neutrophil ◽

Reactive Oxygen ◽

Neutrophil Granulocytes ◽

Oxygen Species ◽

Reactive Oxygen Species Formation ◽

Extracellular Signal Regulated Kinase ◽

Species Formation ◽

Extracellular Signal ◽

Kinase Pathway

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Reactive Oxygen Species Mediate Cyclic Strain-induced Endothelin-1 Gene Expression via Ras/Raf/extracellular Signal-regulated Kinase Pathway in Endothelial Cells

Journal of Molecular and Cellular Cardiology ◽

10.1006/jmcc.2001.1444 ◽

2001 ◽

Vol 33 (10) ◽

pp. 1805-1814 ◽

Cited By ~ 76

Author(s):

Tzu-Hurng Cheng ◽

Neng-Lang Shih ◽

Shin-Yee Chen ◽

Shih-Hurng Loh ◽

Pao-Yun Cheng ◽

...

Keyword(s):

Gene Expression ◽

Reactive Oxygen Species ◽

Endothelial Cells ◽

Reactive Oxygen ◽

Cyclic Strain ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Endothelin 1 ◽

Extracellular Signal ◽

Kinase Pathway

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γ-Tocotrienol Promotes TRAIL-Induced Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase/p53–Mediated Upregulation of Death Receptors

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-10-0277 ◽

2010 ◽

Vol 9 (8) ◽

pp. 2196-2207 ◽

Cited By ~ 49

Author(s):

Ramaswamy Kannappan ◽

Jayaraj Ravindran ◽

Sahdeo Prasad ◽

Bokyung Sung ◽

Vivek R. Yadav ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Death Receptors ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Induced Apoptosis

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Copper-Induced Stimulation of Extracellular Signal-Regulated Kinase in Trout Hepatocytes: The Role of Reactive Oxygen Species, Ca2+, and Cell Energetics and the Impact of Extracellular Signal-Regulated Kinase Signaling on Apoptosis and Necrosis

Toxicological Sciences ◽

10.1093/toxsci/kfl006 ◽

2006 ◽

Vol 92 (2) ◽

pp. 464-475 ◽

Cited By ~ 29

Author(s):

Muhammad Nawaz ◽

Claudia Manzl ◽

Veronika Lacher ◽

Gerhard Krumschnabel

Keyword(s):

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Oxygen Species ◽

Kinase Signaling ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Apoptosis And Necrosis ◽

The Impact ◽

Stimulation Of

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Discussion of the Role of the Extracellular Signal-Regulated Kinase-Phospholipase A2Pathway in Production of Reactive Oxygen Species in Alzheimer's Disease

Neurochemical Research ◽

10.1023/a:1022389503105 ◽

2003 ◽

Vol 28 (2) ◽

pp. 319-326 ◽

Cited By ~ 24

Author(s):

Jannike M. Andersen ◽

Oddvar Myhre ◽

Frode Fonnum

Keyword(s):

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Reactive Oxygen ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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Role of Reactive Oxygen Species-Sensitive Extracellular Signal-Regulated Kinase Pathway in Angiotensin II-Induced Endothelin-1 Gene Expression in Vascular Endothelial Cells

Journal of Vascular Research ◽

10.1159/000076247 ◽

2004 ◽

Vol 41 (1) ◽

pp. 64-74 ◽

Cited By ~ 38

Author(s):

Yung-Ho Hsu ◽

Jin-Jer Chen ◽

Nen-Chung Chang ◽

Cheng-Hsien Chen ◽

Ju-Chi Liu ◽

...

Keyword(s):

Gene Expression ◽

Reactive Oxygen Species ◽

Endothelial Cells ◽

Vascular Endothelial Cells ◽

Vascular Endothelial ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase Pathway

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Hydrogen sulfide protects PC12 cells against reactive oxygen species and extracellular signal-regulated kinase 1/2-mediated downregulation of glutamate transporter-1 expression induced by chemical hypoxia

International Journal of Molecular Medicine ◽

10.3892/ijmm.2012.1090 ◽

2012 ◽

Vol 30 (5) ◽

pp. 1126-1132 ◽

Cited By ~ 19

Author(s):

LIANGCAN XIAO ◽

AIPING LAN ◽

LIQIU MO ◽

WENMING XU ◽

NAN JIANG ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Hydrogen Sulfide ◽

Pc12 Cells ◽

Glutamate Transporter ◽

Reactive Oxygen ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Chemical Hypoxia ◽

Extracellular Signal ◽

Glutamate Transporter 1

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Reactive Oxygen Species and Extracellular Signal-Regulated Kinase 1/2 Mediate Hexachlorobenzene-Induced Cell Death in FRTL-5 Rat Thyroid Cells

Toxicological Sciences ◽

10.1093/toxsci/kft117 ◽

2013 ◽

Vol 134 (2) ◽

pp. 276-290 ◽

Cited By ~ 10

Author(s):

Florencia Chiappini ◽

Carolina Pontillo ◽

Andrea S. Randi ◽

Laura Alvarez ◽

Diana L. Kleiman de Pisarev

Keyword(s):

Reactive Oxygen Species ◽

Cell Death ◽

Reactive Oxygen ◽

Oxygen Species ◽

Thyroid Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Rat Thyroid

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Retraction: γ-Tocotrienol Promotes TRAIL-Induced Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase/p53–Mediated Upregulation of Death Receptors

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-18-0869 ◽

2018 ◽

Vol 17 (9) ◽

pp. 2072-2072

Keyword(s):

Reactive Oxygen Species ◽

Reactive Oxygen ◽

Death Receptors ◽

Oxygen Species ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Induced Apoptosis

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