scholarly journals Reactive Oxygen Species and Extracellular Signal-Regulated Kinase 1/2 Mediate Hexachlorobenzene-Induced Cell Death in FRTL-5 Rat Thyroid Cells

2013 ◽  
Vol 134 (2) ◽  
pp. 276-290 ◽  
Author(s):  
Florencia Chiappini ◽  
Carolina Pontillo ◽  
Andrea S. Randi ◽  
Laura Alvarez ◽  
Diana L. Kleiman de Pisarev
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Thyroid Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Rat Thyroid

scholarly journals Reactive Oxygen Species and Age-Related Genes p66Shc, Sirtuin, FoxO3 and Klotho in Senescence

2010 ◽  
Vol 3 (2) ◽  
pp. 77-85 ◽  
Author(s):  
Igor Afanas'ev
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Radical Anion ◽  
Gene Activation ◽  
Reactive Oxygen ◽  
Cell Senescence ◽  
Oxygen Species ◽  
Extracellular Signal Regulated Kinase ◽  
Age Related ◽  
Extracellular Signal

Reactive oxygen species (ROS) superoxide and hydrogen peroxide perform important signaling functions in many physiological and pathophysiological processes. Cell senescence and organismal age are not exemptions. Aging-regulating genesp66shc, Sirtuin, FOXO3aandKlothoare new important factors which are stimulated by ROS signaling. It has been shown that ROS participate in initiation and prolongation of gene-dependent aging development. ROS also participate in the activation of protein kinases Akt/PKB and extracellular signal-regulated kinase ERK, which by themselves or through gene activation stimulates or retards cell senescence. Different retarding/stimulating effects of ROS might depend on the nature of signaling species—superoxide or hydrogen peroxide. Importance of radical anion superoxide as a signaling molecule with “super-nucleophilic” properties points to the possibility of the use of superoxide scavengers (SOD mimetics, ubiquinones and flavonoids) for retarding the development of aging.

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