scholarly journals Cytochrome P450 3As Gene Expression and Testosterone 6β-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term

2010 ◽  
Vol 33 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Kayoko Maezawa ◽  
Tamihide Matsunaga ◽  
Takashi Takezawa ◽  
Makoto Kanai ◽  
Satoshi Ohira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Full Term ◽  
Fetal Membranes ◽  
Hydroxylase Activity

scholarly journals Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 350
Author(s):  
Julianty Frost ◽  
Mark Frost ◽  
Michael Batie ◽  
Hao Jiang ◽  
Sonia Rocha
Keyword(s):  
Gene Expression ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Regulator ◽  
Hydroxylase Activity ◽  
Control Of Gene Expression ◽  
Prolyl Hydroxylases ◽  
Chromatin Organisation ◽  
Sense And Respond ◽  
Almost All ◽  
And Function

Hypoxia—reduction in oxygen availability—plays key roles in both physiological and pathological processes. Given the importance of oxygen for cell and organism viability, mechanisms to sense and respond to hypoxia are in place. A variety of enzymes utilise molecular oxygen, but of particular importance to oxygen sensing are the 2-oxoglutarate (2-OG) dependent dioxygenases (2-OGDs). Of these, Prolyl-hydroxylases have long been recognised to control the levels and function of Hypoxia Inducible Factor (HIF), a master transcriptional regulator in hypoxia, via their hydroxylase activity. However, recent studies are revealing that dioxygenases are involved in almost all aspects of gene regulation, including chromatin organisation, transcription and translation. We highlight the relevance of HIF and 2-OGDs in the control of gene expression in response to hypoxia and their relevance to human biology and health.

scholarly journals Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity

1996 ◽  
Vol 271 (21) ◽  
pp. 12496-12501 ◽  
Author(s):  
Gordon C. Ibeanu ◽  
Burhan I. Ghanayem ◽  
Patricia Linko ◽  
Leiping Li ◽  
Lee G. Pedersen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Hydroxylase Activity ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

A Pharmacodynamic Analysis of TCDD-Induced Cytochrome P450 Gene Expression in Multiple Tissues: Dose- and Time-Dependent Effects

1998 ◽  
Vol 151 (2) ◽  
pp. 294-310 ◽  
Author(s):  
Michael J. Santostefano ◽  
Xiaofeng Wang ◽  
Vicki M. Richardson ◽  
David G. Ross ◽  
Michael J. DeVito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 Gene ◽  
P450 Gene ◽  
Pharmacodynamic Analysis

scholarly journals Detoxification and Immune Transcriptomic Response of the Gill Tissue of Bay Scallop (Argopecten irradians) Following Exposure to the Algicide Palmitoleic Acid

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 139 ◽  
Author(s):  
Cheng Chi ◽  
Sib Giri ◽  
Jin Jun ◽  
Hyoun Kim ◽  
Sang Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Palmitoleic Acid ◽  
Molecular Mechanisms ◽  
Functional Enrichment ◽  
Alexandrium Tamarense ◽  
Read Length ◽  
Related Factor ◽  
Transcriptomic Response ◽  
Bay Scallop

Palmitoleic acid (PA) is an effective algicide against Alexandrium tamarense. However, the toxicological mechanism of PA exposure is unclear. The transcript abundance and differentially expressed genes (DEGs) in gills of bay scallop were investigated following 80 mg/L PA exposure up to 48 h using the Illumina HiSeq 4000 deep-sequencing platform with the recommended read length of 100 bp. De novo assembly of paired-end reads yielded 62,099 unigenes; 5414 genes were identified as being significantly increased, and 4452 were decreased. Based on gene ontology classification and enrichment analysis, the ‘cellular process’, ‘metabolic process’, ‘response to stimulus’, and ‘catalytic process’ with particularly high functional enrichment were revealed. The DEGs, which are related to detoxification and immune responses, revealed that acid phosphatase, fibrinogen C domain-containing protein, cyclic AMP-responsive element-binding protein, glutathione reductase, ATP-binding cassette, nuclear factor erythroid 2-related factor, NADPH2:quinone reductase, and cytochrome P450 4F22, 4B1, and 2C8-related gene expression decreased. In contrast, some genes related to glutathione S-transferase, C-type lectin, superoxide dismutase, toll-like receptors, and cytochrome P450 2C14, 2U1, 3A24 and 4A2 increased. The results of current research will be a valuable resource for the investigation of gene expression stimulated by PA, and will help understanding of the molecular mechanisms underlying the scallops’ response to PA exposure.

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