Fibronectin-Mediated Hepatocyte Shape Change Reprograms Cytochrome P450 2C11 Gene Expression via an Integrin-Signaled Induction of Ribonuclease Activity

2000 ◽  
Vol 58 (5) ◽  
pp. 976-981 ◽  
Author(s):  
Conrad P. Hodgkinson ◽  
Matthew C. Wright ◽  
Alan J. Paine
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Shape Change ◽  
Ribonuclease Activity ◽  
Cytochrome P450 2C11

scholarly journals Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes

1995 ◽  
Vol 270 (42) ◽  
pp. 25233-25238 ◽  
Author(s):  
Jinqiang Chen ◽  
Mariana Nikolova-Karakashian ◽  
Alfred H. Merrill ◽  
Edward T. Morgan
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Interleukin 1 ◽  
Rat Hepatocytes ◽  
Cytochrome P450 2C11

A Pharmacodynamic Analysis of TCDD-Induced Cytochrome P450 Gene Expression in Multiple Tissues: Dose- and Time-Dependent Effects

1998 ◽  
Vol 151 (2) ◽  
pp. 294-310 ◽  
Author(s):  
Michael J. Santostefano ◽  
Xiaofeng Wang ◽  
Vicki M. Richardson ◽  
David G. Ross ◽  
Michael J. DeVito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 Gene ◽  
P450 Gene ◽  
Pharmacodynamic Analysis

scholarly journals Detoxification and Immune Transcriptomic Response of the Gill Tissue of Bay Scallop (Argopecten irradians) Following Exposure to the Algicide Palmitoleic Acid

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 139 ◽  
Author(s):  
Cheng Chi ◽  
Sib Giri ◽  
Jin Jun ◽  
Hyoun Kim ◽  
Sang Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Palmitoleic Acid ◽  
Molecular Mechanisms ◽  
Functional Enrichment ◽  
Alexandrium Tamarense ◽  
Read Length ◽  
Related Factor ◽  
Transcriptomic Response ◽  
Bay Scallop

Palmitoleic acid (PA) is an effective algicide against Alexandrium tamarense. However, the toxicological mechanism of PA exposure is unclear. The transcript abundance and differentially expressed genes (DEGs) in gills of bay scallop were investigated following 80 mg/L PA exposure up to 48 h using the Illumina HiSeq 4000 deep-sequencing platform with the recommended read length of 100 bp. De novo assembly of paired-end reads yielded 62,099 unigenes; 5414 genes were identified as being significantly increased, and 4452 were decreased. Based on gene ontology classification and enrichment analysis, the ‘cellular process’, ‘metabolic process’, ‘response to stimulus’, and ‘catalytic process’ with particularly high functional enrichment were revealed. The DEGs, which are related to detoxification and immune responses, revealed that acid phosphatase, fibrinogen C domain-containing protein, cyclic AMP-responsive element-binding protein, glutathione reductase, ATP-binding cassette, nuclear factor erythroid 2-related factor, NADPH2:quinone reductase, and cytochrome P450 4F22, 4B1, and 2C8-related gene expression decreased. In contrast, some genes related to glutathione S-transferase, C-type lectin, superoxide dismutase, toll-like receptors, and cytochrome P450 2C14, 2U1, 3A24 and 4A2 increased. The results of current research will be a valuable resource for the investigation of gene expression stimulated by PA, and will help understanding of the molecular mechanisms underlying the scallops’ response to PA exposure.

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