scholarly journals Comparative Study of the Usefulness of the Drug-Induced Lymphocyte Stimulation Test and the Leukocyte Migration Test in Drug Allergies

2008 ◽  
Vol 31 (2) ◽  
pp. 299-304 ◽  
Author(s):  
Mikio Saito ◽  
Motohiro Yagi ◽  
Katsuji Uno ◽  
Koichiro Takanaka
Keyword(s):  
Comparative Study ◽  
Stimulation Test ◽  
Leukocyte Migration ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Migration Test ◽  
Drug Induced ◽  
Leukocyte Migration Test

Interstitial lung disease following FOLFOX + FOLFIRI and bevacizumab therapy associated with leucovorin: A case report

2017 ◽  
Vol 24 (7) ◽  
pp. 540-543 ◽  
Author(s):  
Satoru Mitsuboshi ◽  
Hiromi Kozakai ◽  
Hitoshi Yamada ◽  
Kazuhiko Nagai ◽  
Tomoyasu Furukawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Stimulation Test ◽  
Leukocyte Migration ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Migration Test ◽  
Drug Induced ◽  
Leukocyte Migration Test

Chemotherapy-induced interstitial lung disease in colorectal cancer patients is rare but represents a life-threatening adverse reaction. We report here a case of interstitial lung disease following chemotherapy for metastatic colorectal cancer and the interesting results of the drug-induced lymphocyte stimulation test and leukocyte migration test. After chemotherapy with oxaliplatin plus infusional 5-fluorouracil and leucovorin (FOLFOX) plus bevacizumab followed by irinotecan plus infusional 5-fluorouracil and leucovorin (FOLFIRI), the patient was hospitalized with fever and chills. Laboratory data showed neutropenia and eosinophilia. Computed tomography revealed ground-glass opacities in both lungs; therefore, we diagnosed chemotherapy-induced interstitial lung disease. Steroid therapy was effective. We suspected irinotecan to be the etiological drug for interstitial lung disease in this patient because interstitial lung disease developed after switching the regimen from FOLFOX to FOLFIRI. However, drug-induced lymphocyte stimulation test and leukocyte migration test results were positive for only leucovorin and negative for irinotecan and 5-fluorouracil. This is the first case to show positive results on the drug-induced lymphocyte stimulation test and leukocyte migration test for only leucovorin and negative results for antineoplastic drugs. Our findings suggest that all drugs included in chemotherapy regimens have the potential to induce interstitial lung disease, and if rechallenge chemotherapy is considered, the drug-induced lymphocyte stimulation test and leukocyte migration test are expected to be useful for determining the drug that needs to be excluded.

scholarly journals Lymphocyte Stimulation Test with Tetrazolium-Based Colorimetric Assay for Diagnosis of Drug-Induced Allergic Hepatitis.

1994 ◽  
Vol 17 (7) ◽  
pp. 921-926 ◽  
Author(s):  
Tomoaki YOSHIMURA ◽  
Chikako KURITA ◽  
Futoshi YAMAZAKI ◽  
Satoshi NAKANO ◽  
Hiroichi NAGAI
Keyword(s):  
Colorimetric Assay ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced

scholarly journals Diagnostic value of drug lymphocyte stimulation test and evaluation of diagnostic criteria for drug induced liver injury.

Kanzo ◽  
2001 ◽  
Vol 42 (9) ◽  
pp. 448-454 ◽  
Author(s):  
Masaaki WATANABE ◽  
Akitaka SHIBUYA ◽  
Akihiko SATOMICHI ◽  
Kouji ONO ◽  
Takeshi TSUCHIHASHI ◽  
...  
Keyword(s):  
Liver Injury ◽  
Diagnostic Criteria ◽  
Diagnostic Value ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Test And Evaluation ◽  
Drug Lymphocyte Stimulation Test

Eosinophilic peritonitis induced by sucroferric oxyhydroxide

2020 ◽  
Vol 40 (4) ◽  
pp. 419-421
Author(s):  
Saori Minato ◽  
Haruhisa Miyazawa ◽  
Taisuke Kitano ◽  
Mitsutoshi Shindo ◽  
Kiyonori Ito ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Phosphate Binder ◽  
Immunosuppressive Agents ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Chronic Glomerulonephritis ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Iron Based

A 49-year-old woman developed eosinophilic peritonitis 2 months after starting continuous ambulatory peritoneal dialysis because of congenital right kidney hypoplasia and chronic glomerulonephritis. This was shown to have been induced by sucroferric oxyhydroxide, an iron-based phosphate binder, using a drug-induced lymphocyte stimulation test. Her eosinophilic peritonitis was improved after stopping the administration of sucroferric oxyhydroxide without providing any immunosuppressive agents.

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