scholarly journals Anticancer Effect of Kalpaamruthaa on Mammary Carcinoma in Rats with Reference to Glycoprotein Components, Lysosomal and Marker Enzymes

2006 ◽  
Vol 29 (3) ◽  
pp. 565-569 ◽  
Author(s):  
Krishnamurthy Veena ◽  
Palanivelu Shanthi ◽  
Panchanatham Sachdanandam
Keyword(s):  
Mammary Carcinoma ◽  
Marker Enzymes ◽  
Anticancer Effect

scholarly journals ANTICANCER EFFECT OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA ON MAMMARY CARCINOMA IN RATS WITH REFERENCE TO GLYCOPROTEIN COMPONENTS, LYSOSOMAL, AND MARKER ENZYMES

2017 ◽  
Vol 10 (9) ◽  
pp. 180
Author(s):  
Nandhakumar Elumalai ◽  
Indumathi Parameswaran ◽  
Sachidanandam T Panchanatham
Keyword(s):  
Body Weight ◽  
Mammary Carcinoma ◽  
Lysosomal Enzymes ◽  
Methanolic Extract ◽  
The Body ◽  
Active Principle ◽  
Dependent Manner ◽  
Marker Enzymes ◽  
Annona Squamosa ◽  
Anticancer Effect

  Objectives: The aim is to evaluate the anticancer potential of Annona squamosa (AS) against 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats.Methods: The tumor was induced in Sprague-Dawley rats by gastric intubation of 25 mg DMBA in 1 ml olive oil. After 3 months of induction period, the methanolic extract of AS at different doses of 100, 150, 200, 250, and 300 mg/kg body weight were administered orally a dose per day to mammary carcinoma-bearing rats for 45 days. The serum and tissue levels of glycoprotein components as well as the activities of marker enzymes and lysosomal enzymes were measured in DMBA-induced mammary carcinoma-bearing rats.Results: Administration of AS resulted in decrease in the levels of marker and lysosomal enzymes and also alterations in the body weight and tumor volume were also restored to near normalcy in a dose-dependent manner. The results of the present study indicate that AS has anticancer effect and it exhibits its potential effect at the dosage of 200 mg/kg body weight in mammary carcinoma-bearing rats.Conclusions: Based on the results obtained, it can be concluded that the methanol extract of AS possesses anticancer properties. Further study is needed to isolate the active principle of this extract responsible for anticancer activity to develop the future pharmaceuticals.

scholarly journals Biochemical Evaluation of Glycoprotein Components, Lysosomal Enzymes and Marker Enzymes upon Kalpaamruthaa Administration in Experimental Mammary Carcinoma Rats

2007 ◽  
Vol 53 (6) ◽  
pp. 644-654 ◽  
Author(s):  
Vanu Ramkumar Ramprasath ◽  
Gopalakrishnan Akila ◽  
Palanivelu Shanthi ◽  
Panchanatham Sachdanandam
Keyword(s):  
Mammary Carcinoma ◽  
Lysosomal Enzymes ◽  
Marker Enzymes ◽  
Biochemical Evaluation

Basal Lamina Formation in DMBA Induced Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 534-535
Author(s):  
I. Russo ◽  
J. Saby ◽  
J. Russo
Keyword(s):  
Mammary Carcinoma ◽  
Virgin Female ◽  
Mammary Glands ◽  
Sesame Oil ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Intermediate Type ◽  
Sprague Dawley ◽  
Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

1967 ◽  
Vol 25 ◽  
pp. 180-181
Author(s):  
John H.L. Watson ◽  
John L. Swedo ◽  
R.W. Talley
Keyword(s):  
Mammary Carcinoma ◽  
Osmium Tetroxide ◽  
Estrogen Therapy ◽  
Ultrastructural Level ◽  
Uranyl Acetate ◽  
Human Mammary Carcinoma ◽  
Surgical Biopsy ◽  
Lead Hydroxide ◽  
Preliminary Study ◽  
Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

RENAL FUNCTION AND KIDNEY SIZE FOLLOWING HYPOPHYSECTOMY IN MAN

1965 ◽  
Vol 48 (3) ◽  
pp. 348-354 ◽  
Author(s):  
Thomas Falkheden ◽  
Ingmar Wickbom
Keyword(s):  
Renal Function ◽  
Diabetic Retinopathy ◽  
Glomerular Filtration Rate ◽  
Plasma Flow ◽  
Mammary Carcinoma ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Kidney Weight ◽  
Kidney Size ◽  
Before And After

ABSTRACT Measurements of glomerular filtration rate (GFR) and renal plasma flow (RPF) were performed in close connection with roentgenographic estimation of kidney size, before and after hypophysectomy, in 10 patients (four cases of metastatic mammary carcinoma, five cases of diabetic retinopathy and one case of acromegaly). Hypophysectomy was regularly followed by a decrease in GFR and RPF. In most cases, a reduction in the roentgenographic kidney size was also observed. However, the changes in the roentgenographic kidney size and calculated kidney weight after hypophysectomy were smaller and occurred at a slower rate than the alterations in GFR and RPF. The results favour the view that, primarily, the decrease in GFR and RPF following hypophysectomy is essentially functional rather than due to a reduced kidney mass.

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