scholarly journals Therapeutic Effect of Hydro-Ethanolic Extract of Pothos scandens L on key Carbohydrate Metabolizing Enzymes and Xenobiotic Marker Enzymes in DMBA Induced Experimental Mammary Carcinoma

2017 ◽  
Vol 51 (3) ◽  
pp. 418-426
Author(s):  
Jethinlalkhosh Jayapalan Prasannakumari ◽  
Praveena Padmam ◽  
Victor Arokia Doss
Keyword(s):  
Therapeutic Effect ◽  
Mammary Carcinoma ◽  
Ethanolic Extract ◽  
Marker Enzymes ◽  
Metabolizing Enzymes

scholarly journals Anti-diabetic Activity of Ethanolic Extract of Elaeocarpus serratus L. in Streptozotocin-Induced Diabetic Rats

2016 ◽  
Vol 8 (01) ◽  
Author(s):  
DH Geetha ◽  
Indhiramuthu Jayashree ◽  
M. Rajeswari
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Liver Marker Enzymes

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

Biological and Phytochemical Screening of Tephrosia purpurea extract on Chemically Induced Hepatocellular Carcinoma with Reference to Biochemical Parameters

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Irfan Aziz ◽  
Birendra Shrivastava ◽  
Chandana Venkateswara Rao ◽  
Sadath Ali
Keyword(s):  
Free Radicals ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Marker Enzymes ◽  
Tephrosia Purpurea ◽  
Single Intraperitoneal Injection ◽  
Chemically Induced ◽  
Ccl4 Treatment ◽  
Dose Dependent

Tephrosia purpurea possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Tephrosia purpurea would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Tephrosia purpurea is very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of aTephrosia purpurea of 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt.Tephrosia purpureaextract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Tephrosia purpurea extract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats.

scholarly journals EFFICACY OF TRIDHAM AND 1,2,3,4,6-PENTA-O-GALLOYL-β-D-GLUCOSE IN REVERSING LIPID PEROXIDATION LEVELS AND MITOCHONDRIAL ANTIOXIDANT STATUS IN 7,12-DIMETHYLBENZENEANTHRACENE (DMBA) INDUCED BREAST CANCER IN SPRAGUE-DAWLEY RATS

2016 ◽  
Vol 8 (9) ◽  
pp. 288 ◽  
Author(s):  
Stalin Ramakrishnan ◽  
Karthick Dharmalingam ◽  
Sachidanandham T Panchanatham ◽  
Shanthi Palanivelu
Keyword(s):  
Lipid Peroxidation ◽  
Therapeutic Effect ◽  
Mammary Carcinoma ◽  
Antioxidant Status ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Sprague Dawley ◽  
Standard Drug ◽  
Gastric Intubation ◽  
Group I

<p><strong>Objective: </strong>To determine the effect of <em>Tridham</em> (TD) and 1,2,3,4,6-penta-O-galloyl-β-d-glucose(PGG) on lipid peroxidation levels and mitochondrial antioxidants status in experimental mammary carcinoma.</p><p><strong>Methods</strong>:<strong> </strong><em>Elaecoarpus ganitrus </em>(fruits), <em>Terminalia chebula </em>(seed coats), <em>Prosopis cineraria </em>(leaves)<em>, </em>adult female albino rats of Sprague-Dawley strain weighing 170–190 g and 7,12-dimethylbenzeneanthracene (DMBA) were used for this study. Group I control rats, Group II rats mammary carcinoma induced with DMBA (25 mg in 1 ml olive oil) by gastric intubation. Group III, IV and V DMBA induced rats were treated with TD (400 mg/kg. b. wt/day), PGG (30 mg/kg. b. wt/day) and standard drug, Cyclophosphamide (30 mg/kg. b. wt/day), respectively for 48 d by gastric intubation. Group VI and VII rats served as TD and PGG treated controls, respectively for 48 d by gastric intubation. At the end of the experimental period, the rats were anaesthetized and sacrificed. Mammary glands were isolated and used for biochemical assays and histopathological evaluation.</p><p><strong>Results: </strong>In rats with cancer, the lipid peroxide levels (LPO) were significantly increased and mitochondrial antioxidant levels were decreased. Treatment with TD and PGG decreased LPO levels and increased mitochondrial antioxidant status in mammary carcinoma bearing rats. Histopathological analysis also confirmed the therapeutic effect of TD and PGG. No significant adverse effect was observed in sole drug treated group of rats.</p><p><strong>Conclusion: </strong>TD and PGG have definite therapeutic effect in experimental mammary carcinoma and inhibit growth of cancer cells by restoring mitochondrial antioxidant status and energy metabolism to normal states.</p>

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Biochemical Evaluation of Glycoprotein Components, Lysosomal Enzymes and Marker Enzymes upon Kalpaamruthaa Administration in Experimental Mammary Carcinoma Rats

2007 ◽  
Vol 53 (6) ◽  
pp. 644-654 ◽  
Author(s):  
Vanu Ramkumar Ramprasath ◽  
Gopalakrishnan Akila ◽  
Palanivelu Shanthi ◽  
Panchanatham Sachdanandam
Keyword(s):  
Mammary Carcinoma ◽  
Lysosomal Enzymes ◽  
Marker Enzymes ◽  
Biochemical Evaluation

scholarly journals ANTICANCER EFFECT OF METHANOLIC EXTRACT OF ANNONA SQUAMOSA ON MAMMARY CARCINOMA IN RATS WITH REFERENCE TO GLYCOPROTEIN COMPONENTS, LYSOSOMAL, AND MARKER ENZYMES

2017 ◽  
Vol 10 (9) ◽  
pp. 180
Author(s):  
Nandhakumar Elumalai ◽  
Indumathi Parameswaran ◽  
Sachidanandam T Panchanatham
Keyword(s):  
Body Weight ◽  
Mammary Carcinoma ◽  
Lysosomal Enzymes ◽  
Methanolic Extract ◽  
The Body ◽  
Active Principle ◽  
Dependent Manner ◽  
Marker Enzymes ◽  
Annona Squamosa ◽  
Anticancer Effect

  Objectives: The aim is to evaluate the anticancer potential of Annona squamosa (AS) against 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats.Methods: The tumor was induced in Sprague-Dawley rats by gastric intubation of 25 mg DMBA in 1 ml olive oil. After 3 months of induction period, the methanolic extract of AS at different doses of 100, 150, 200, 250, and 300 mg/kg body weight were administered orally a dose per day to mammary carcinoma-bearing rats for 45 days. The serum and tissue levels of glycoprotein components as well as the activities of marker enzymes and lysosomal enzymes were measured in DMBA-induced mammary carcinoma-bearing rats.Results: Administration of AS resulted in decrease in the levels of marker and lysosomal enzymes and also alterations in the body weight and tumor volume were also restored to near normalcy in a dose-dependent manner. The results of the present study indicate that AS has anticancer effect and it exhibits its potential effect at the dosage of 200 mg/kg body weight in mammary carcinoma-bearing rats.Conclusions: Based on the results obtained, it can be concluded that the methanol extract of AS possesses anticancer properties. Further study is needed to isolate the active principle of this extract responsible for anticancer activity to develop the future pharmaceuticals.

Effects of dietary fish oil on human mammary carcinoma and on lipid-metabolizing enzymes

Lipids ◽  
1989 ◽  
Vol 24 (4) ◽  
pp. 290-295 ◽  
Author(s):  
Charlotte E. Borgeson ◽  
Lani Pardini ◽  
Ronald S. Pardini ◽  
Ronald C. Reitz
Keyword(s):  
Fish Oil ◽  
Mammary Carcinoma ◽  
Human Mammary Carcinoma ◽  
Metabolizing Enzymes ◽  
Lipid Metabolizing Enzymes ◽  
Dietary Fish

scholarly journals THERAPEUTIC EFFECT OF NYMPHAEA ALBA LINN. FLOWERS AGAINST ISONIAZID-INDUCED HEPATOTOXICITY: AN EXPERIMENTAL STUDY

2018 ◽  
Vol 11 (5) ◽  
pp. 333
Author(s):  
Mohammad Nasiruddin ◽  
Irfan Ahmad Khan ◽  
Sayeedul Hasan Arif
Keyword(s):  
Biochemical Parameters ◽  
Ethanolic Extract ◽  
Antioxidant Property ◽  
Albino Rats ◽  
Marker Enzymes ◽  
Liver Marker Enzymes ◽  
Stress Markers ◽  
Significant Reversal ◽  
Nymphaea Alba ◽  
Wistar Albino Rats

Objective: This study was designed to evaluate the effect of ethanolic extract of Nymphaea alba (NAEE) Linn. flowers on liver marker enzymes, histology, and antioxidant tests against isoniazid (INH)-induced hepatotoxicity in rats.Methods: Wistar albino rats were treated with INH (50 mg/kg) for 28 days to induce hepatotoxicity. Silymarin (100 mg/kg) and NAEE Linn flowers in 200 mg/kg and 400 mg/kg doses, respectively, were used as standard and test drugs. Liver marker enzymes and histological examination of livers were performed to demonstrate the effect of NAEE against INH-induced hepatotoxicity. Catalase [CAT], glutathione, and malondialdehyde (MDA) levels were estimated to evaluate the antioxidant property of the NAEE extract.Results: The NAEE extract in 200 mg/kg and 400 mg/kg doses significantly decreased INH-induced elevation of liver marker enzymes as well as oxidative stress markers (CAT, glutathione, and MDA) in rats. Changes in biochemical parameters were supported by histological improvements of the liver.Conclusion: The NAEE Linn flowers in 200 mg/kg and 400 mg/kg doses showed a significant reversal of hepatic damage which was induced by INH in rats.

scholarly journals Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats

2018 ◽  
Vol 25 (3) ◽  
pp. 431-436 ◽  
Author(s):  
Althaf Hussain Shaik ◽  
Nayab Rasool Shaik ◽  
Abdul Kareem Mohammed ◽  
Suliman Yousef Al Omar ◽  
Altaf Mohammad ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Ethanolic Extract ◽  
Marker Enzymes

scholarly journals Cardioprotective Effect of Ethanolic Flower Extract of ClitoriaTernatea on Doxorubicin Induced Cardiotoxicity in Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1604-1611
Author(s):  
Tamizhselvi A ◽  
Durairaj S ◽  
Mohamed Sadiq A ◽  
Gopinath G ◽  
Rajeshkumar S
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Heart Tissue ◽  
Marker Enzyme ◽  
Aspartate Transaminase ◽  
Marker Enzymes ◽  
Serum Enzyme ◽  
Cardiac Marker ◽  
Flower Extract

There was a significant evidence that there are several of the medicinal plants encompass the prospective to treat cardiovascular disease. In this study, Doxorubicin is used as an effectual induction of cardiotoxicity and heart malfunction in the taken experimental rats which is an anthracycline chemotherapeutic mediator used to the treat of a wide variety of malignancies. To examine the shielding property of ethanolic flower extract of clitoraternatea  (EECT) scheduled doxorubicin(DOX) persuaded cardiotoxicity via albino wistar rats,through inspect the enzymatic,non-enzymatic antioxidant position,serum enzyme and Histopathology tissue.Experimental rats been provoked cardiotoxicity by means of a generous single dose of doxorubicin (15mg /body weight ) and treated orally through an ethanolic extract of clitoraternatea (EECT)  for 14 days (100 mg/kg bw, 200 mg/kg bw and 300mg/kg bw,n=5).On15 days, the rats are sacrificed by treated through Ketamine –Xylazine,Biochemical as well as histological remarks of the heart tissues had carry out. Cardiotoxicity had been calculated throughout to establish the cardio marker enzyme levels such as (LDH) Lactic acid dehydrogenase,(CK-MB) Creatinin kinase and (AST) Aspartate transaminase at the finish of the study. Managementthrough EECT of 200mg/kg and 300mg/kgconsiderablyreduced the levels of cardiac marker enzymes(p<0.05), and as wellminimize the decrease of weight of the heart of DOX treated group. In heart tissue superoxide dismutase, glutathione and catalase heightsbe significantly greater than before and lipid oxide peroxide (LPO) significantly decreased in the extract (200 &300 mg /kg bw) treated rats when compared to DOX treated with the significance of  P< 0.05. There was no significant recovery of the 100 mg/kg of EECT. These results will suggested that EECT having potential anti-cardiotoxic effects induced by Doxorubicin by preventing oxidative injure provoke by DOX in heart of taken experimental animals.

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