scholarly journals Anti-hyperglycemic Effect of Fangchinoline Isolated from Stephania Tetrandra Radix in Streptozotocin-Diabetic Mice

2003 ◽  
Vol 26 (3) ◽  
pp. 313-317 ◽  
Author(s):  
Taiki Tsutsumi ◽  
Shinjiro Kobayashi ◽  
Yuan Ying Liu ◽  
Hitoshi Kontani
Keyword(s):  
Diabetic Mice ◽  
Hyperglycemic Effect ◽  
Stephania Tetrandra

scholarly journals Anti-Hyperglycemic Effects of Refined Fractions from Cyclocarya Paliurus Leaves on Streptozotocin-Induced Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6886
Author(s):  
Zheling Feng ◽  
Zhujun Fang ◽  
Cheng Chen ◽  
Chi Teng Vong ◽  
Jiali Chen ◽  
...  
Keyword(s):  
Water Extract ◽  
Ethanol Extract ◽  
C2c12 Myotubes ◽  
Chemical Components ◽  
Diabetic Mice ◽  
Cyclocarya Paliurus ◽  
Insulin Tolerance ◽  
Glucose Tolerance Tests ◽  
Glucose Stimulated Insulin Secretion ◽  
Hyperglycemic Effect

To identify the chemical components responsible for the anti-hyperglycemic effect of Cyclocarya paliurus (Batal.) Iljinsk (Juglandaceae) leaves, an ethanol extract (CPE) and a water extract (CPW) of C. paliurus leaves, as well as their total flavonoids (CPF), triterpenoids (CPT) and crude polysaccharides (CPP), were prepared and assessed on streptozotocin (STZ)-induced diabetic mice. After being orally administrated once a day for 24 days, CPF (300 mg/kg), CPP (180 mg/kg), or CPF+CPP (300 mg/kg CPF + 180 mg/kg CPP) treatment reversed STZ-induced body weight and muscle mass losses. The glucose tolerance tests and insulin tolerance tests suggested that CPF, CPP, and CPF+CPP showed anti-hyperglycemic effect in STZ-induced diabetic mice. Furthermore, CPF enhances glucose-stimulated insulin secretion in MIN6 cells and insulin-stimulated glucose uptake in C2C12 myotubes. CPF and CPP suppressed inflammatory cytokine levels in STZ-induced diabetic mice. Additionally, CPF and CPP improved STZ-induced diabetic nephropathy assessed by H&E staining, blood urea nitrogen content, and urine creatinine level. The molecular networking and Emperor analysis results indicated that CPF showed potential anti-hyperglycemic effects, and HPLC–MS/MS analysis indicated that CPF contains 3 phenolic acids and 9 flavonoids. In contrast, CPT (650 mg/kg) and CPC (300 mg/kg CPF + 180 mg/kg CPP + 650 mg/kg CPT) did not show anti-hyperglycemic effect. Taken together, polysaccharides and flavonoids are responsible for the anti-hyperglycemic effect of C. paliurus leaves, and the clinical application of C. paliurus need to be refined.

The Anti-Hyperglycemic Effect of Plants in Genus Gynura Cass.

2009 ◽  
Vol 37 (05) ◽  
pp. 961-966 ◽  
Author(s):  
Wei-Lin Li ◽  
Bing-Ru Ren ◽  
Min-Zhuo ◽  
Yong Hu ◽  
Chang-Gen Lu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Ethyl Acetate ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Mice ◽  
Crude Drug ◽  
Pharmacological Tests ◽  
Ethanol Extracts ◽  
Hyperglycemic Effect

Gynura divaricata (L.) DC and G. bicolor DC are used as secret recipes to treat diabetes mellitus in some parts of China. Pharmacological tests were performed to prove the anti-hyperglycemic effect of these two plants of genus Gynura Cass. in this study. Both water and 95% ethanol extracts of fresh G. divaricata had significant effects on lowering blood glucose level in normal mice, in which the dose of 0.4 g (crude drug)/kg of 95% ethanol extract was more effective than 50 mg/kg glyburide. The ethyl acetate and n-butanol extracts of dried G. divaricata had significant effects on lowering blood glucose level in normal and alloxan diabetic mice too. Both ethyl acetate and n-butanol extracts of dried G. bicolor showed very significant effect on lowering blood glucose level to normal and alloxan-diabetic mice, and the dose 4.0 g (crude drug)/kg had a more hypoglycemic effect than 50 mg/kg glyburide in normal mice.

scholarly journals Anti-hyperglycemic Effect of Stephania Glabra Tubers in Alloxan Induced Diabetic Mice

1970 ◽  
Vol 11 (1) ◽  
pp. 17-19 ◽  
Author(s):  
Deepak Kumar Semwal ◽  
Usha Rawat ◽  
Ruchi Badoni ◽  
Ravindra Semwal ◽  
Randhir Singh
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Key Words ◽  
Ethanolic Extract ◽  
Hypoglycemic Activity ◽  
Diabetic Mice ◽  
Antihyperglycemic Activity ◽  
Hypoglycemic Agent ◽  
Different Doses ◽  
Hyperglycemic Effect

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard. Key words: Stephania glabra, Menispermaceae, hydroxypalmatine, alloxan, glibenclamide, hypoglycemic activity DOI:10.3329/jom.v11i1.4262 J Medicine 2010: 11: 17-19

scholarly journals Anti-hyperglycemic activity of Heliotropium strigosum (Boraginaecae) whole plant extract in alloxan-induced diabetic mice

2017 ◽  
Vol 16 (10) ◽  
pp. 2425-2430
Author(s):  
Huma Aslam ◽  
Arif-ullah Khan ◽  
Najeeb-ur- Rehman ◽  
Fawad Ali ◽  
Humaira Nadeem ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Whole Plant ◽  
Hyperglycemic Effect

Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce the blood glucose level of alloxan-induced diabetic mice.Methods: Preliminary phytochemical analysis was carried out using standard  procedures. Diabetes was induced in Balb/c mice by injecting alloxan (200 mg/kg i.p.). The crude methanol extract of Heliotropium strigosum (Hs.Cr, 30, 100 and 300 mg/kg doses) was administered daily to alloxan-induced diabetic mice for 15 days and its effect on fasting blood glucose levels, body weight and oral glucose tolerancewas evaluated. Two control groups (non-diabetic control and diabetic control)  received normal saline (0.2 ml). Metformin (500 mg/kg) was used as reference standard.Results: Heliotropium strigosum showed positive for the presence of alkaloids, tannins and flavonoids. The extract (30, 100 and 300 mg/kg) caused significant reduction in the fasting blood glucose level of alloxan-induced diabetic mice on days 5, 10 and 15 compared to diabetic control (p < 0.001). In this regard, the  anti-hyperglycemic effect compared to the reference (metformin). The extract also timedependently decreased the body weight of the treated animals as well as improved tolerance of the oral glucose overload.Conclusion: These results indicate that Heliotropium strigosum possesses  anti-hyperglycemic effect, reduces body weight and enhances the tolerance of  glucose overload in mice. Further studies are therefore required to determine its  feasiilty as an alternate herbal medicine in the management of diabetes in humans.Keywords: Heliotropium strigosum, Anti-hyperglycemic, Alloxan-induced diabetic mice, Blood glucose, Oral glucose tolerance, Body weight

Pharmacological Studies on Anti-Hyperglycemic Effect of Folium Eriobotryae

2007 ◽  
Vol 35 (04) ◽  
pp. 705-711 ◽  
Author(s):  
Wei-Lin Li ◽  
Ju-Lan Wu ◽  
Bing-Ru Ren ◽  
Jian Chen ◽  
Chang-Gen Lu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Ethanol Extract ◽  
Eriobotrya Japonica ◽  
Diabetic Mice ◽  
Crude Drug ◽  
Pharmacological Tests ◽  
Pharmacological Studies ◽  
Treatment Of Diabetes ◽  
Hyperglycemic Effect

Folium Eriobotryae, dried leaves of Eriobotrya japonica (Thunb.) Lindl. is a traditional Chinese medicine with rich resources in China. This research investigated the anti-hyperglycemic effect of Folium Eriobotryae on normal and alloxan-diabetic mice. The 70% ethanol extract of Folium Eriobotryae (EJA-0) in doses of 15, 30 and 60 g (crude drug)/kg exerted a significant hypoglycemic effect on alloxan-diabetic mice, among which 30 g/kg of EJA-0 was more effective than 100 mg/kg of phenformin. The total sesquiterpenes (EJA-1) 30 g (crude drug)/kg had significant effect on lowering blood glucose level in normal or/and alloxan-diabetic mice. The tests of maximum dosage and acute toxicity showed that EJA-1 was safe (MD = 360 g/kg, LD50 = 400.1 g/kg). The pharmacological tests on anti-hyperglycemic effects of EJA-0 and EJA-1 prove that Folium Eriobotryae is an outstanding material to develop medicine for treatment of diabetes mellitus.

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