scholarly journals Effect of Lipophilicity on in Vivo Iontophoretic Delivery. I. NSAIDs.

2001 ◽  
Vol 24 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Yoshikazu TASHIRO ◽  
Shozo SHICHIBE ◽  
Yasuki KATO ◽  
Eiji HAYAKAWA ◽  
Kunio ITOH
Keyword(s):  
Iontophoretic Delivery

Cellular mechanisms underlying cutaneous pressure-induced vasodilation: in vivo involvement of potassium channels

2005 ◽  
Vol 289 (1) ◽  
pp. H174-H180 ◽  
Author(s):  
Ambroise Garry ◽  
Dominique Sigaudo-Roussel ◽  
Sandra Merzeau ◽  
Odile Dumont ◽  
Jean Louis Saumet ◽  
...  
Keyword(s):  
Channel Blocker ◽  
Microvascular Dysfunction ◽  
Nerve Fibers ◽  
Cellular Mechanisms ◽  
Local Pressure ◽  
Cutaneous Vasodilation ◽  
Pressure Application ◽  
Iontophoretic Delivery ◽  
Small Conductance

In the skin of humans and rodents, local pressure induces localized cutaneous vasodilation, which may be protective against pressure-induced microvascular dysfunction and lesion formation. Once activated by the local pressure application, capsaicin-sensitive nerve fibers release neuropeptides that act on the endothelium to synthesize and release nitric oxide (NO) and prostaglandins, leading to the development of the cutaneous pressure-induced vasodilation (PIV). The present study was undertaken to test in vivo the hypothesis that PIV is mediated or modulated by differential activation of K+ channels in anesthetized rats using pharmacological methods. Local pressure was applied at 11.1 Pa/s. Endothelium-independent and -dependent vasodilation were tested using iontophoretic delivery of sodium nitroprusside (SNP) and acetylcholine (ACh), respectively, and was correlated with PIV response. PIV was reduced after systemic administration of tetraethylammonium (a nonspecific K+ channel blocker), iberiotoxin [a specific large-conductance Ca2+-activated K+ (BKCa) channel blocker], and glibenclamide [a specific ATP-sensitive K+ (KATP) channel blocker], whereas PIV was unchanged by apamin (a specific small-conductance Ca2+-activated K+channel blocker) and 4-aminopyridine (a specific voltage-sensitive K+ channel blocker). The responses to SNP and ACh were reduced by iberiotoxin but were unchanged by glibenclamide. We conclude that the cellular mechanism of PIV in skin involves BKCa and KATP channels. We suggest that the opening of BKCa and KATP channels contributes to the hyperpolarization of vascular smooth muscle cells to produce PIV development mainly via the NO and prostaglandin pathways, respectively.

Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140—A Multitarget Compound for Alzheimer’s Disease

2019 ◽  
Vol 16 (8) ◽  
pp. 3460-3468 ◽  
Author(s):  
Mayank Singhal ◽  
Virginia Merino ◽  
Michela Rosini ◽  
Andrea Cavalli ◽  
Yogeshvar N. Kalia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Iontophoretic Delivery

Controlled non-invasive transdermal iontophoretic delivery of zolmitriptan hydrochloride in vitro and in vivo

2009 ◽  
Vol 72 (2) ◽  
pp. 304-309 ◽  
Author(s):  
Sonal R. Patel ◽  
Hui Zhong ◽  
Ashutosh Sharma ◽  
Yogeshvar N. Kalia
Keyword(s):  
Non Invasive ◽  
Iontophoretic Delivery

In vitro and in vivo evaluation of transdermal iontophoretic delivery of hydromorphone

1990 ◽  
Vol 11 (1-3) ◽  
pp. 123-135 ◽  
Author(s):  
R.V. Padmanabhan ◽  
J.B. Phipps ◽  
G.A. Lattin ◽  
R.J. Sawchuk
Keyword(s):  
In Vivo Evaluation ◽  
Iontophoretic Delivery

In vitro and in vivo transdermal iontophoretic delivery of naloxone, an opioid antagonist

2012 ◽  
Vol 422 (1-2) ◽  
pp. 132-138 ◽  
Author(s):  
Rie Yamamoto ◽  
Shinri Takasuga ◽  
Yoshimasa Yoshida ◽  
Shoichi Mafune ◽  
Katsuya Kominami ◽  
...  
Keyword(s):  
Opioid Antagonist ◽  
Iontophoretic Delivery

In vivo transdermal iontophoretic delivery of growth hormone releasing factor GRF (1–44) in hairless guinea pigs

1992 ◽  
Vol 18 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Saran Kumar ◽  
Hing Char ◽  
Sunil Patel ◽  
David Piemontese ◽  
A.Waseem Malick ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Guinea Pigs ◽  
Growth Hormone Releasing Factor ◽  
Iontophoretic Delivery ◽  
Hairless Guinea Pigs

In Vivo Iontophoretic Delivery of Salmon Calcitonin Across Microporated Skin

2012 ◽  
Vol 101 (8) ◽  
pp. 2861-2869 ◽  
Author(s):  
Viswatej Vemulapalli ◽  
Yun Bai ◽  
Haripriya Kalluri ◽  
Anushree Herwadkar ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Salmon Calcitonin ◽  
Iontophoretic Delivery
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