In Vivo Iontophoretic Delivery of Salmon Calcitonin Across Microporated Skin

2012 ◽  
Vol 101 (8) ◽  
pp. 2861-2869 ◽  
Author(s):  
Viswatej Vemulapalli ◽  
Yun Bai ◽  
Haripriya Kalluri ◽  
Anushree Herwadkar ◽  
Hyun Kim ◽  
...  
Keyword(s):  
Salmon Calcitonin ◽  
Iontophoretic Delivery

In vivo iontophoretic delivery and pharmacokinetics of salmon calcitonin

2005 ◽  
Author(s):  
A CHATURVEDULA ◽  
D JOSHI ◽  
C ANDERSON ◽  
R MORRIS ◽  
W SEMBROWICH ◽  
...  
Keyword(s):  
Salmon Calcitonin ◽  
Iontophoretic Delivery

Transbuccal iontophoretic delivery of a salmon calcitonin using a pulse depolarization system.

1998 ◽  
Vol 13 (5) ◽  
pp. 353-357
Author(s):  
Kazuya Katagai ◽  
Katsuhiro Nakamura ◽  
Kazutaka Inoue ◽  
Hirotoshi Adachi ◽  
Naruhito Higo
Keyword(s):  
Salmon Calcitonin ◽  
Iontophoretic Delivery

Cellular mechanisms underlying cutaneous pressure-induced vasodilation: in vivo involvement of potassium channels

2005 ◽  
Vol 289 (1) ◽  
pp. H174-H180 ◽  
Author(s):  
Ambroise Garry ◽  
Dominique Sigaudo-Roussel ◽  
Sandra Merzeau ◽  
Odile Dumont ◽  
Jean Louis Saumet ◽  
...  
Keyword(s):  
Channel Blocker ◽  
Microvascular Dysfunction ◽  
Nerve Fibers ◽  
Cellular Mechanisms ◽  
Local Pressure ◽  
Cutaneous Vasodilation ◽  
Pressure Application ◽  
Iontophoretic Delivery ◽  
Small Conductance

In the skin of humans and rodents, local pressure induces localized cutaneous vasodilation, which may be protective against pressure-induced microvascular dysfunction and lesion formation. Once activated by the local pressure application, capsaicin-sensitive nerve fibers release neuropeptides that act on the endothelium to synthesize and release nitric oxide (NO) and prostaglandins, leading to the development of the cutaneous pressure-induced vasodilation (PIV). The present study was undertaken to test in vivo the hypothesis that PIV is mediated or modulated by differential activation of K+ channels in anesthetized rats using pharmacological methods. Local pressure was applied at 11.1 Pa/s. Endothelium-independent and -dependent vasodilation were tested using iontophoretic delivery of sodium nitroprusside (SNP) and acetylcholine (ACh), respectively, and was correlated with PIV response. PIV was reduced after systemic administration of tetraethylammonium (a nonspecific K+ channel blocker), iberiotoxin [a specific large-conductance Ca2+-activated K+ (BKCa) channel blocker], and glibenclamide [a specific ATP-sensitive K+ (KATP) channel blocker], whereas PIV was unchanged by apamin (a specific small-conductance Ca2+-activated K+channel blocker) and 4-aminopyridine (a specific voltage-sensitive K+ channel blocker). The responses to SNP and ACh were reduced by iberiotoxin but were unchanged by glibenclamide. We conclude that the cellular mechanism of PIV in skin involves BKCa and KATP channels. We suggest that the opening of BKCa and KATP channels contributes to the hyperpolarization of vascular smooth muscle cells to produce PIV development mainly via the NO and prostaglandin pathways, respectively.

Transdermal iontophoretic delivery of salmon calcitonin

2000 ◽  
Vol 200 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Shu-Lun Chang ◽  
Günter A Hofmann ◽  
Lei Zhang ◽  
Leonard J Deftos ◽  
Ajay K Banga
Keyword(s):  
Salmon Calcitonin ◽  
Iontophoretic Delivery

scholarly journals Effect of Lipophilicity on in Vivo Iontophoretic Delivery. I. NSAIDs.

2001 ◽  
Vol 24 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Yoshikazu TASHIRO ◽  
Shozo SHICHIBE ◽  
Yasuki KATO ◽  
Eiji HAYAKAWA ◽  
Kunio ITOH
Keyword(s):  
Iontophoretic Delivery

Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140—A Multitarget Compound for Alzheimer’s Disease

2019 ◽  
Vol 16 (8) ◽  
pp. 3460-3468 ◽  
Author(s):  
Mayank Singhal ◽  
Virginia Merino ◽  
Michela Rosini ◽  
Andrea Cavalli ◽  
Yogeshvar N. Kalia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Iontophoretic Delivery

scholarly journals Design and Characterizations of Inhalable Poly(lactic-co-glycolic acid) Microspheres Prepared by the Fine Droplet Drying Process for a Sustained Effect of Salmon Calcitonin

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1311 ◽  
Author(s):  
Hideyuki Sato ◽  
Aiko Tabata ◽  
Tatsuru Moritani ◽  
Tadahiko Morinaga ◽  
Takahiro Mizumoto ◽  
...  
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
Salmon Calcitonin ◽  
Glycolic Acid ◽  
Pharmacological Action ◽  
Conformational Structure ◽  
Intratracheal Administration ◽  
Fine Droplet ◽  
Droplet Drying

The present study aimed to develop inhalable poly (lactic-co-glycolic acid) (PLGA)-based microparticles of salmon calcitonin (sCT) for sustained pharmacological action by the fine droplet drying (FDD) process, a novel powderization technique employing printing technologies. PLGA was selected as a biodegradable carrier polymer for sustained-release particles of sCT (sCT/SR), and physicochemical characterizations of sCT/SR were conducted. To estimate the in vivo efficacy of the sCT/SR respirable powder (sCT/SR-RP), plasma calcium levels were measured after intratracheal administration in rats. The particle size of sCT/SR was 3.6 µm, and the SPAN factor, one of the parameters to present the uniformity of particle size distribution, was calculated to be 0.65. In the evaluation of the conformational structure of sCT, no significant changes were observed in sCT/SR even after the FDD process. The drug release from sCT/SR showed a biphasic pattern with an initial burst and slow diffusion in simulated lung fluid. sCT/SR-RP showed fine inhalation performance, as evidenced by a fine particle fraction value of 28% in the cascade impactor analysis. After the insufflation of sCT samples (40 µg-sCT/kg) in rats, sCT/SR-RP could enhance and prolong the hypocalcemic action of sCT possibly due to the sustained release and pulmonary absorption of sCT. From these observations, the strategic application of the FDD process could be efficacious to provide PLGA-based inhalable formulations of sCT, as well as other therapeutic peptides, to enhance their biopharmaceutical potentials.

Controlled non-invasive transdermal iontophoretic delivery of zolmitriptan hydrochloride in vitro and in vivo

2009 ◽  
Vol 72 (2) ◽  
pp. 304-309 ◽  
Author(s):  
Sonal R. Patel ◽  
Hui Zhong ◽  
Ashutosh Sharma ◽  
Yogeshvar N. Kalia
Keyword(s):  
Non Invasive ◽  
Iontophoretic Delivery
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