scholarly journals Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Dopamine Content in PC12 Cells.

2001 ◽  
Vol 24 (1) ◽  
pp. 103-105 ◽  
Author(s):  
Jung Soo SHIN ◽  
Jae Joon LEE ◽  
Youngsoo KIM ◽  
Chong Kil LEE ◽  
Yeo Pyo YUN ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Content

Inhibitory Effects of Higenamine on Dopamine Content in PC12 Cells

Planta Medica ◽  
1999 ◽  
Vol 65 (05) ◽  
pp. 452-455 ◽  
Author(s):  
Jung Shin ◽  
Hye Yun-Choi ◽  
Eung Kim ◽  
Myung Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Content

Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells

1998 ◽  
Vol 244 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Jung Soo Shin ◽  
Kyong Tai Kim ◽  
Myung Koo Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

scholarly journals Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Zenji Kawakami ◽  
Yuji Omiya ◽  
Kazushige Mizoguchi
Keyword(s):  
Cell Death ◽  
Effective Dose ◽  
Pc12 Cells ◽  
Psychological Symptoms ◽  
Glutamate Uptake ◽  
Inhibitory Effects ◽  
Alternative Formula ◽  
Cultured Astrocytes ◽  
Citrus Unshiu Peel ◽  
Glutamatergic Pathways

The traditional Japanese Kampo medicine yokukansan (YKS) is effective for behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease. As the pharmacological mechanisms, YKS is known to protect astrocytes from thiamine-deficiency (TD)-induced decreased glutamate (Glu) uptake and neuron model cells (PC 12 cells) from Glu-induced death. Yokukansankachimpihange (YKSCH) is an alternative formula to YKS, in which Citrus unshiu peel and Pinellia tuber are added to the YKS components, and is sometimes used to treat BPSD, but its pharmacological properties remain unknown. This study aims to investigate the cellular pharmacological effects of YKS and YKSCH on glutamatergic pathways, compare their efficacy, and determine the differences and similarities in the activities between these formulations. First, we examined the effects of YKS and YKSCH on Glu uptake by cultured astrocytes under TD conditions. We observed significant ameliorative effects of YKS and YKSCH on the TD-induced decrease in Glu uptake, with a 50% effective dose of 8.9 ± 1.8 μg/mL and 45.3 ± 9.2 μg/mL, respectively. Second, using cultured PC12 cells as a model for neurons, we examined the effects of YKS and YKSCH on Glu-induced cell death. We observed that YKS and YKSCH had significant inhibitory effects on Glu-induced cell death, with a 30% effective dose of 51.4 ± 20.8 μg/mL and 49.2 ± 11.0 μg/mL, respectively. Thus, while YKSCH was less effective than YKS in ameliorating the TD-induced decrease in Glu uptake by astrocytes, the two drugs showed similar inhibitory effects on Glu-induced PC12 cell death. These findings are important for understanding the differences and similarities in pharmacological actions between these drugs.

scholarly journals Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 cells

1999 ◽  
Vol 79 ◽  
pp. 49
Author(s):  
Yutaka Maruyama ◽  
Yuko Suzuki ◽  
Hiroki Teraoka ◽  
Hisato Iwata ◽  
Akio Kazusaka ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects

scholarly journals Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells

1997 ◽  
Vol 20 (6) ◽  
pp. 662-662 ◽  
Author(s):  
Jung Soo Shin ◽  
Sang Sun Lee ◽  
Myung Koo Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

scholarly journals Inhibitory Effects ofCoptidis rhizomaand Berberine on Cocaine-Induced Sensitization

2009 ◽  
Vol 6 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Bombi Lee ◽  
Chae Ha Yang ◽  
Dae-Hyun Hahm ◽  
Eun Sang Choe ◽  
Hye-Jung Lee ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Daily Injection ◽  
Inhibitory Effects ◽  
Behavioral Alterations ◽  
Main Compound ◽  
Dopaminergic Systems ◽  
Dopamine Content ◽  
Cocaine Hydrochloride ◽  
The Central Nervous System ◽  
Neuronal Functions

Substantial evidence suggests that the behavioral and reinforcing effects of cocaine can be mediated by the central dopaminergic systems. Repeated injections of cocaine produce an increase in locomotor activity and the expression of tyrosine hydroxylase (TH) in the main dopaminergic areas. Protoberberine alkaloids affect neuronal functions.Coptidis rhizoma(CR) and its main compound, berberine (BER) reduced the dopamine content in the central nervous system. In order to investigate the effects of CR or BER on the repeated cocaine-induced neuronal and behavioral alterations, we examined the influence of CR or BER on the repeated cocaine-induced locomotor activity and the expression of TH in the brain by using immunohistochemistry. Male SD rats were given repeated injections of saline or cocaine hydrochloride (15 mg/kg, i.p. for 10 consecutive days) followed by one challenge injection on the 4th day after the last daily injection. Cocaine challenge (15 mg/kg, i.p) produced a larger increase in locomotor activity and expression of TH in the central dopaminergic areas. Pretreatment with CR (50, 100, 200 and 400 mg/kg, p.o.) and BER (200 mg/kg, p.o.) 30 min before the daily injections of cocaine significantly inhibited the cocaine-induced locomotor activity as well as TH expression in the central dopaminergic areas. Our data demonstrate that the inhibitory effects of CR and BER on the repeated cocaine-induced locomotor activity were closely associated with the reduction of dopamine biosynthesis and post-synaptic neuronal activity. These results suggest that CR and BER may be effective for inhibiting the behavioral effects of cocaine by possibly modulating the central dopaminergic system.

scholarly journals Amphetamine reduces vesicular dopamine content in dexamethasone-differentiated PC12 cells only following l-DOPA exposure

2009 ◽  
Vol 111 (2) ◽  
pp. 624-633 ◽  
Author(s):  
Laura Hondebrink ◽  
Jan Meulenbelt ◽  
Johan G. Timmerman ◽  
Martin van den Berg ◽  
Remco H. S. Westerink
Keyword(s):  
Pc12 Cells ◽  
Differentiated Pc12 Cells ◽  
Dopamine Content
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