scholarly journals Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells

1997 ◽  
Vol 20 (6) ◽  
pp. 662-662 ◽  
Author(s):  
Jung Soo Shin ◽  
Sang Sun Lee ◽  
Myung Koo Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells

1998 ◽  
Vol 244 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Jung Soo Shin ◽  
Kyong Tai Kim ◽  
Myung Koo Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells

1997 ◽  
Vol 20 (5) ◽  
pp. 510-512 ◽  
Author(s):  
Jung Soo Shin ◽  
Sang Sun Lee ◽  
Myung Koo Lee
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

Inhibitory effects of tributyltin on dopamine biosynthesis in rat PC12 cells

2002 ◽  
Vol 332 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Yu Mi Kim ◽  
Jae Joon Lee ◽  
Shou Yu Yin ◽  
Youngsoo Kim ◽  
Jong Kil Lee ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects ◽  
Dopamine Biosynthesis

scholarly journals Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Zenji Kawakami ◽  
Yuji Omiya ◽  
Kazushige Mizoguchi
Keyword(s):  
Cell Death ◽  
Effective Dose ◽  
Pc12 Cells ◽  
Psychological Symptoms ◽  
Glutamate Uptake ◽  
Inhibitory Effects ◽  
Alternative Formula ◽  
Cultured Astrocytes ◽  
Citrus Unshiu Peel ◽  
Glutamatergic Pathways

The traditional Japanese Kampo medicine yokukansan (YKS) is effective for behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease. As the pharmacological mechanisms, YKS is known to protect astrocytes from thiamine-deficiency (TD)-induced decreased glutamate (Glu) uptake and neuron model cells (PC 12 cells) from Glu-induced death. Yokukansankachimpihange (YKSCH) is an alternative formula to YKS, in which Citrus unshiu peel and Pinellia tuber are added to the YKS components, and is sometimes used to treat BPSD, but its pharmacological properties remain unknown. This study aims to investigate the cellular pharmacological effects of YKS and YKSCH on glutamatergic pathways, compare their efficacy, and determine the differences and similarities in the activities between these formulations. First, we examined the effects of YKS and YKSCH on Glu uptake by cultured astrocytes under TD conditions. We observed significant ameliorative effects of YKS and YKSCH on the TD-induced decrease in Glu uptake, with a 50% effective dose of 8.9 ± 1.8 μg/mL and 45.3 ± 9.2 μg/mL, respectively. Second, using cultured PC12 cells as a model for neurons, we examined the effects of YKS and YKSCH on Glu-induced cell death. We observed that YKS and YKSCH had significant inhibitory effects on Glu-induced cell death, with a 30% effective dose of 51.4 ± 20.8 μg/mL and 49.2 ± 11.0 μg/mL, respectively. Thus, while YKSCH was less effective than YKS in ameliorating the TD-induced decrease in Glu uptake by astrocytes, the two drugs showed similar inhibitory effects on Glu-induced PC12 cell death. These findings are important for understanding the differences and similarities in pharmacological actions between these drugs.

scholarly journals Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 cells

1999 ◽  
Vol 79 ◽  
pp. 49
Author(s):  
Yutaka Maruyama ◽  
Yuko Suzuki ◽  
Hiroki Teraoka ◽  
Hisato Iwata ◽  
Akio Kazusaka ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Inhibitory Effects
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