scholarly journals Search for Naturally Occuring Substances to Prevent the Complications of Diabetes. Part III. Inhibitory Effect of Chalcone Derivatives on Recombinant Human Aldose Reductase.

1999 ◽  
Vol 22 (3) ◽  
pp. 323-325 ◽  
Author(s):  
Susumu IWATA ◽  
Nobuyuki NAGATA ◽  
Ayako OMAE ◽  
Shino YAMAGUCHI ◽  
Yoshihito OKADA ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effect ◽  
Complications Of Diabetes ◽  
Chalcone Derivatives

Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation

2004 ◽  
Vol 56 (7) ◽  
pp. 941-945 ◽  
Author(s):  
Soon Sung Lim ◽  
Kuk Hyun Shin ◽  
Sang Hoon Jung ◽  
Kye Jung Shin ◽  
Dong Chan Kim ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Aldose Reductase ◽  
Inhibitory Effect ◽  
Rat Lens Aldose Reductase

scholarly journals Inhibitory Activities ofStauntonia hexaphyllaLeaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Shin Hwa Kwon ◽  
Set Byeol Kim ◽  
Soon Sung Lim
Keyword(s):  
Aldose Reductase ◽  
Advanced Glycation End Products ◽  
Inhibitory Activity ◽  
Solvent System ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Rat Lens Aldose Reductase ◽  
Glycation End Products ◽  
End Products ◽  
Etoac Fraction

Stauntonia hexaphylla(Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3.0 g) was subjected to Sephadex LH-20 column chromatography, for further fractionation, with 100% MeOH solvent system to investigate its effect on RLAR and AGEs. Phytochemical investigation of SHL led to the isolation of seven compounds. Among the isolated compounds, chlorogenic acid, calceolarioside B, luteolin-3′-O-β-D-glucopyranoside, quercetin-3-O-β-D-glucopyranoside, and luteolin-7-O-β-D-glucopyranoside exhibited significant inhibitory activity against RLAR with IC50in the range of 7.34–23.99 μM. In addition, 3-(3,4-dihydroxyphenyl) propionic acid, neochlorogenic acid, and luteolin-3′-O-β-D-glucopyranoside exhibited the most potent inhibitory activity against formation of AGEs, with an IC50value of 115.07–184.06 μM, compared to the positive control aminoguanidine (820.44 μM). Based on these findings, SHL dietary supplements could be considered for the prevention and/or treatment of diabetes complication.

Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenasein vitro

2006 ◽  
Vol 20 (7) ◽  
pp. 605-606 ◽  
Author(s):  
Catherine Koukoulitsa ◽  
Chariklia Zika ◽  
Dimitra Hadjipavlou–Litina ◽  
Vassilis J. Demopoulos ◽  
Helen Skaltsa
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effect
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