Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenasein vitro

2006 ◽  
Vol 20 (7) ◽  
pp. 605-606 ◽  
Author(s):  
Catherine Koukoulitsa ◽  
Chariklia Zika ◽  
Dimitra Hadjipavlou–Litina ◽  
Vassilis J. Demopoulos ◽  
Helen Skaltsa
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effect

Inhibitory effect of pyridyloxy- or phenoxylphenoxyalkanate derivatives on rat lens aldose reductase and rat platelet aggregation

2004 ◽  
Vol 56 (7) ◽  
pp. 941-945 ◽  
Author(s):  
Soon Sung Lim ◽  
Kuk Hyun Shin ◽  
Sang Hoon Jung ◽  
Kye Jung Shin ◽  
Dong Chan Kim ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Aldose Reductase ◽  
Inhibitory Effect ◽  
Rat Lens Aldose Reductase

scholarly journals Inhibitory Activities ofStauntonia hexaphyllaLeaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Shin Hwa Kwon ◽  
Set Byeol Kim ◽  
Soon Sung Lim
Keyword(s):  
Aldose Reductase ◽  
Advanced Glycation End Products ◽  
Inhibitory Activity ◽  
Solvent System ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Rat Lens Aldose Reductase ◽  
Glycation End Products ◽  
End Products ◽  
Etoac Fraction

Stauntonia hexaphylla(Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3.0 g) was subjected to Sephadex LH-20 column chromatography, for further fractionation, with 100% MeOH solvent system to investigate its effect on RLAR and AGEs. Phytochemical investigation of SHL led to the isolation of seven compounds. Among the isolated compounds, chlorogenic acid, calceolarioside B, luteolin-3′-O-β-D-glucopyranoside, quercetin-3-O-β-D-glucopyranoside, and luteolin-7-O-β-D-glucopyranoside exhibited significant inhibitory activity against RLAR with IC50in the range of 7.34–23.99 μM. In addition, 3-(3,4-dihydroxyphenyl) propionic acid, neochlorogenic acid, and luteolin-3′-O-β-D-glucopyranoside exhibited the most potent inhibitory activity against formation of AGEs, with an IC50value of 115.07–184.06 μM, compared to the positive control aminoguanidine (820.44 μM). Based on these findings, SHL dietary supplements could be considered for the prevention and/or treatment of diabetes complication.

scholarly journals The Inhibitory Effect ofPrunella vulgarisL. on Aldose Reductase and Protein Glycation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hong Mei Li ◽  
Jin Kyu Kim ◽  
Jai Man Jang ◽  
Sang Oh Kwon ◽  
Cheng Bi Cui ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effect ◽  
Protein Glycation ◽  
Prunella Vulgaris ◽  
Inhibitory Effects ◽  
Advanced Glycation ◽  
High Concentration ◽  
Potent Inhibition ◽  
Glycation End Products

To evaluate the aldose reductase (AR) enzyme inhibitory ability ofPrunella vulgarisL. extract, six compounds were isolated and tested for their effects. The components were subjected toin vitrobioassays to investigate their inhibitory assays using rat lens aldose reductase (rAR) and human recombinant AR (rhAR). Among them, caffeic acid ethylene ester showed the potent inhibition, with the IC50values of rAR and rhAR at3.2±0.55 μM and12.58±0.32 μM, respectively. In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/concentration of substrate, this compound showed noncompetitive inhibition against rhAR. Furthermore, it inhibited galactitol formation in a rat lens incubated with a high concentration of galactose. Also it has antioxidative as well as advanced glycation end products (AGEs) inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.

scholarly journals Blanching influences the phenolics composition, antioxidant activity, and inhibitory effect ofAdansonia digitataleaves extract onα-amylase,α-glucosidase, and aldose reductase

2016 ◽  
Vol 5 (2) ◽  
pp. 233-242 ◽  
Author(s):  
Emmanuel A. Irondi ◽  
Jacob K. Akintunde ◽  
Samson O. Agboola ◽  
Aline A. Boligon ◽  
Margareth L. Athayde
Keyword(s):  
Antioxidant Activity ◽  
Aldose Reductase ◽  
Inhibitory Effect
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