scholarly journals Antitumor Activity of Doxorubicin Encapsulated in Poly(ethylene glycol)-Coated Liposomes.

1995 ◽  
Vol 18 (9) ◽  
pp. 1234-1237 ◽  
Author(s):  
Junichi HOSODA ◽  
Sakae UNEZAKI ◽  
Kazuo MARUYAMA ◽  
Seishi TSUCHIYA ◽  
Motoharu IWATSURU
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

2019 ◽  
Vol 14 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Batool Hashemi-Beni ◽  
Mohsen Minaiyan ◽  
Saeedeh Enteshari
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tissue Distribution ◽  
Tumor Cells ◽  
Maleic Acid ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Background: Due to the low water solubility of Docetaxel (DTX), it is formulated with ethanol and Tween 80 with lots of side effects. For this reason, special attention has been paid to formulate it in new drug nano-carriers. Objective: The goal of this study was to evaluate the safety, antitumor activity and tissue distribution of the novel synthesized Raloxifene (RA) targeted polymeric micelles. Methods: DTX-loaded RA-targeted polymeric micelles composed of poly(styrene-maleic acid)- poly(amide-ether-ester-imide)-poly(ethylene glycol) (SMA-PAEE-PEG) were prepared and their antitumor activity was studied in MC4-L2 tumor-bearing mice compared with non-targeted micelles and free DTX. Safety of the micelles was studied by Hematoxylin and Eosin (H&E) staining of tumors and major organs of the mice. The drug accumulation in the tumor and major organs was measured by HPLC method. Results: The results showed better tumor growth inhibition and increased survival of mice treated with DTX-loaded in targeted micelles compared to the non-targeted micelles and free DTX. Histopathological studies, H&E staining of tumors and immunohistochemical examination showed the potential of DTX-loaded RA-targeted micelles to inhibit tumor cells proliferation. The higher accumulation of the DTX in the tumor tissue after injection of the micelles compared to the free DTX may indicate the higher uptake of the targeted micelles by the G-Protein-Coupled Estrogen Receptors (GPER). Conclusion: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of the drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX.

scholarly journals Self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates for co-delivery of anticancer drugs

RSC Advances ◽  
2017 ◽  
Vol 7 (47) ◽  
pp. 29591-29598 ◽  
Author(s):  
Yingsa Wang ◽  
Yajie Tian ◽  
Pengbo Zhu ◽  
Yunyun Ma ◽  
Jing He ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Anticancer Drugs ◽  
Oleanolic Acid ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Oleanolic acid (OA) has shown promising antitumor activity.

Antitumor activity of poly(ethylene glycol)–camptothecin conjugate: The inhibition of tumor growth in vivo

2005 ◽  
Vol 110 (1) ◽  
pp. 90-102 ◽  
Author(s):  
Deshan Yu ◽  
Ping Peng ◽  
Sonia S. Dharap ◽  
Yang Wang ◽  
Mary Mehlig ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tumor Growth ◽  
Poly Ethylene Glycol ◽  
Inhibition Of Tumor Growth ◽  
Poly Ethylene

scholarly journals Synthesis and Antitumor Activity of Polyphosphazene/Methoxy-Poly(ethylene glycol)/(Diamine)platinum(II) Conjugates

1999 ◽  
Vol 31 (12) ◽  
pp. 1247-1252 ◽  
Author(s):  
Sang Beom Lee ◽  
Soo-Chang Song ◽  
Jung-Il Jin ◽  
Youn Soo Sohn
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals L-Asparaginase modified by poly(ethylene glycol) derivative with a comb-shaped form: antitumor activity and induction of immune tolerance

1995 ◽  
Vol 16 (2) ◽  
pp. 121-123 ◽  
Author(s):  
TAICHI SEKINE ◽  
YOH KODERA ◽  
TETSUYA SAITO ◽  
MISAO HIROTO ◽  
AYAKO MATSUSHIMA ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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