scholarly journals Self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates for co-delivery of anticancer drugs

RSC Advances ◽  
2017 ◽  
Vol 7 (47) ◽  
pp. 29591-29598 ◽  
Author(s):  
Yingsa Wang ◽  
Yajie Tian ◽  
Pengbo Zhu ◽  
Yunyun Ma ◽  
Jing He ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Anticancer Drugs ◽  
Oleanolic Acid ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Oleanolic acid (OA) has shown promising antitumor activity.

A self-assembled nanoparticle platform based on poly(ethylene glycol)–diosgenin conjugates for co-delivery of anticancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (91) ◽  
pp. 74828-74834 ◽  
Author(s):  
Chunxiao Li ◽  
Lin Dai ◽  
Kefeng Liu ◽  
Lihong Deng ◽  
Tingting Pei ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

We developed a nanoparticle platform based on poly(ethylene glycol)–diosgenin (mPEG–DGN) conjugates for co-delivery of anticancer drug HCPT.

Amphiphilic poly(ethylene glycol)-poly(ε-caprolactone) AB2 miktoarm copolymers for self-assembled nanocarrier systems: synthesis, characterization, and effects of morphology on antitumor activity

2015 ◽  
Vol 6 (4) ◽  
pp. 531-542 ◽  
Author(s):  
Kwonhyeok Yoon ◽  
Han Chang Kang ◽  
Li Li ◽  
Hana Cho ◽  
Mi-Kyoung Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Miktoarm-structured PEG-PCL2 copolymers with morphological versatility for drug delivery.

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

2019 ◽  
Vol 14 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Batool Hashemi-Beni ◽  
Mohsen Minaiyan ◽  
Saeedeh Enteshari
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tissue Distribution ◽  
Tumor Cells ◽  
Maleic Acid ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Background: Due to the low water solubility of Docetaxel (DTX), it is formulated with ethanol and Tween 80 with lots of side effects. For this reason, special attention has been paid to formulate it in new drug nano-carriers. Objective: The goal of this study was to evaluate the safety, antitumor activity and tissue distribution of the novel synthesized Raloxifene (RA) targeted polymeric micelles. Methods: DTX-loaded RA-targeted polymeric micelles composed of poly(styrene-maleic acid)- poly(amide-ether-ester-imide)-poly(ethylene glycol) (SMA-PAEE-PEG) were prepared and their antitumor activity was studied in MC4-L2 tumor-bearing mice compared with non-targeted micelles and free DTX. Safety of the micelles was studied by Hematoxylin and Eosin (H&E) staining of tumors and major organs of the mice. The drug accumulation in the tumor and major organs was measured by HPLC method. Results: The results showed better tumor growth inhibition and increased survival of mice treated with DTX-loaded in targeted micelles compared to the non-targeted micelles and free DTX. Histopathological studies, H&E staining of tumors and immunohistochemical examination showed the potential of DTX-loaded RA-targeted micelles to inhibit tumor cells proliferation. The higher accumulation of the DTX in the tumor tissue after injection of the micelles compared to the free DTX may indicate the higher uptake of the targeted micelles by the G-Protein-Coupled Estrogen Receptors (GPER). Conclusion: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of the drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX.

Poly(ethylene glycol) Self-Assembled Monolayer Island Growth

Langmuir ◽  
2005 ◽  
Vol 21 (7) ◽  
pp. 2981-2987 ◽  
Author(s):  
Jonas Rundqvist ◽  
Jan H. Hoh ◽  
David B. Haviland
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Island Growth ◽  
Self Assembled Monolayer ◽  
Self Assembled ◽  
Poly Ethylene

Poly(ethylene glycol)–paclitaxel–alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases

Biomaterials ◽  
2013 ◽  
Vol 34 (15) ◽  
pp. 3795-3806 ◽  
Author(s):  
Keren Miller ◽  
Chiara Clementi ◽  
Dina Polyak ◽  
Anat Eldar-Boock ◽  
Liat Benayoun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Bone Metastases ◽  
Targeted Treatment ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene
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