scholarly journals Anti-inflammatory Constituents of Topically Applied Crude Drugs. V. Constituents and Anti-inflammatory Effect of Aoki, Aucuba japonica THUNB.

1994 ◽  
Vol 17 (5) ◽  
pp. 665-667 ◽  
Author(s):  
Mineo SHIMIZU ◽  
Takashi TOMOO
1986 ◽  
Vol 34 (6) ◽  
pp. 2614-2617 ◽  
Author(s):  
MINEO SHIMIZU ◽  
HIDEKI FUKUMURA ◽  
HIDEKI TSUJI ◽  
SEIICHI TANAAMI ◽  
TOSHIMITSU HAYASHI ◽  
...  

1988 ◽  
Vol 36 (11) ◽  
pp. 4447-4452 ◽  
Author(s):  
MINEO SHIMIZU ◽  
HISASHI SHOGAWA ◽  
TOSHIMITSU HAYASHI ◽  
MUNEHISA ARISAWA ◽  
SHOICHI SUZUKI ◽  
...  

1988 ◽  
Vol 36 (10) ◽  
pp. 3967-3973 ◽  
Author(s):  
MINEO SHIMIZU ◽  
HIDEKI TSUJI ◽  
HISASHI SHOGAWA ◽  
HIDEKI FUKUMURA ◽  
SEIICHI TANAAMI ◽  
...  

1990 ◽  
Vol 38 (8) ◽  
pp. 2283-2284 ◽  
Author(s):  
Mineo SHIMIZU ◽  
Hisashi SHOGAWA ◽  
Takayasu MATSUZAWA ◽  
Sakiko YONEZAWA ◽  
Toshimitsu HAYASHI ◽  
...  

1992 ◽  
Vol 20 (02) ◽  
pp. 127-134 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-hung Lin ◽  
Hui-Fen Chiu ◽  
Min-Fu Hu

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl 4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD 50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100,300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.


Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.


Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Mollik ◽  
W Mozammel Haq ◽  
S Chandra Bachar ◽  
R Jahan ◽  
M Rahmatullah

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WM Shaik Mossadeq ◽  
K Syamimi ◽  
MP Azyyati ◽  
ZA Zakaria ◽  
AK Arifah ◽  
...  

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
IST Figueiredo ◽  
FT Benevides ◽  
NMS Queiroz ◽  
LM Marques ◽  
TFG Souza ◽  
...  

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