scholarly journals Neurotropic Pyrimidine Heterocyclic Compounds. I. The Newly Synthesized Pyrimidine Compounds Promote Neurite Outgrowth of GOTO and Neuro 2a Neuroblastoma Cell Lines, and Potentiate Nerve Growth Factor (NGF)-Induced Neurite Sprouting of PC 12 Cells.

1993 ◽  
Vol 16 (3) ◽  
pp. 248-253 ◽  
Author(s):  
Akira AWAYA ◽  
Hisashi KOBAYASHI ◽  
Kazutoshi HORIKOMI ◽  
Shuitsu TANAKA ◽  
Ahmed MD. KABIR ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurite Outgrowth ◽  
Cell Lines ◽  
Heterocyclic Compounds ◽  
Neuroblastoma Cell ◽  
Nerve Growth ◽  
Pc 12 Cells ◽  
Promote Neurite Outgrowth ◽  
Neuroblastoma Cell Lines

Characterization of Two Neuroblastoma Cell Lines Expressing Recombinant Nerve Growth Factor Receptors

1991 ◽  
Vol 56 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Usha Rani Reddy ◽  
Gita Venkatakrishnan ◽  
Amit K. Roy ◽  
Jie Chen ◽  
Mattie Hardy ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Growth Factor Receptors ◽  
Nerve Growth ◽  
Nerve Growth Factor Receptors ◽  
Neuroblastoma Cell Lines

Overexpression of nerve growth factor in peritoneal fluid from women with endometriosis may promote neurite outgrowth in endometriotic lesions

2011 ◽  
Vol 95 (3) ◽  
pp. 1123-1126 ◽  
Author(s):  
Maria Luisa Barcena de Arellano ◽  
Julia Arnold ◽  
Filiberto Vercellino ◽  
Vito Chiantera ◽  
Achim Schneider ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurite Outgrowth ◽  
Peritoneal Fluid ◽  
Nerve Growth ◽  
Promote Neurite Outgrowth

Nerve growth factor synthesis by intestinal epithelial cells

1995 ◽  
Vol 269 (3) ◽  
pp. G445-G452 ◽  
Author(s):  
G. W. Varilek ◽  
G. A. Neil ◽  
W. P. Bishop ◽  
J. Lin ◽  
N. J. Pantazis
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Neurite Outgrowth ◽  
Intestinal Epithelial Cells ◽  
Conditioned Media ◽  
Intestinal Epithelial ◽  
Nerve Growth ◽  
Pc 12 Cells ◽  
Isolated Rat

Nerve growth factor (NGF) exists in the gut of adult rats. The cells responsible for NGF synthesis in the gut remain unknown. IEC-6 and Caco-2 cells, established cell culture models of intestinal epithelial cells, were studied to determine whether intestinal epithelial cells, were studied to determine whether they synthesize and release NGF. Conditioned media from both IEC-6 and Caco-2 cells stimulated neurite outgrowth in both rat pheochromocytoma (PC-12) cells and sensory neurons derived from embryonic chick dorsal root ganglia (DRG). The addition of anti-NGF antibody blocked neurite outgrowth in PC-12 cells and partially blocked outgrowth in DRG cells. An NGF-enzyme-linked immunosorbant assay readily detected immunoreactive NGF in conditioned media from both cell lines, whereas cellular extracts from IEC-6, Caco-2, and isolated rat intestinal epithelial cells had low levels of immunoreactivity. Caco-2 monolayers primarily secreted NGF from the basolateral compartment, and interleukin-1 enhanced its secretion. IEC-6, Caco-2, and isolated rat intestinal epithelial cells expressed NGF mRNA as determined by reverse transcription polymerase chain reaction. These observations suggest that intestinal epithelial cells are capable of NGF synthesis.

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