Synthesis of Water-soluble Bottlebrush Polymer with Hydrophobic Core and Hydrophilic Shell as Cylindrical Host for Guest Uptake

2019 ◽  
Vol 48 (11) ◽  
pp. 1410-1413 ◽  
Author(s):  
Yoshihiro Yamauchi ◽  
Kuniyo Yamada ◽  
Yasuhiro Ishida
Keyword(s):  
Water Soluble ◽  
Hydrophobic Core ◽  
Hydrophilic Shell

scholarly journals The behavior of hydrophobic-core/hydrophilic-shell structured microgels at an interface: from Mickering emulsion to colloidosomes with dual-level controlled permeability

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95067-95072 ◽  
Author(s):  
Yi Gong ◽  
Mao Wang ◽  
Jianying He
Keyword(s):  
Hydrophobic Core ◽  
Coarse Level ◽  
Controllable Release ◽  
Model Drug ◽  
Hydrophilic Shell

The release of model drug FITC-Dex from colloidosomes was examined in selected media and the controllable release was achieved by adjusting the pH (coarse level) and the ratio of the shell to core in the microgels (fine level).

scholarly journals Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

2018 ◽  
Vol 10 (7) ◽  
pp. 642-658 ◽  
Author(s):  
Ruolin Du ◽  
Yazhou Wang ◽  
Yuhua Huang ◽  
Yinping Zhao ◽  
Dechuan Zhang ◽  
...  
Keyword(s):  
Drug Eluting Stent ◽  
Hydrophobic Core ◽  
Micro Particles ◽  
Drug Eluting ◽  
Stent Coating ◽  
Design And Testing ◽  
Hydrophilic Shell

Hydrophobic Core/Hydrophilic Shell Amphiphilic Particles

2001 ◽  
Vol 238 (2) ◽  
pp. 414-419 ◽  
Author(s):  
Yang Yun ◽  
Hangquan Li ◽  
Eli Ruckenstein
Keyword(s):  
Hydrophobic Core ◽  
Amphiphilic Particles ◽  
Hydrophilic Shell

scholarly journals Model of Environmental Membrane Field for Transmembrane Proteins

2021 ◽  
Vol 22 (7) ◽  
pp. 3619
Author(s):  
Irena Roterman ◽  
Katarzyna Stapor ◽  
Piotr Fabian ◽  
Leszek Konieczny ◽  
Mateusz Banach
Keyword(s):  
Membrane Proteins ◽  
Protein Modification ◽  
Water Environment ◽  
Water Soluble ◽  
Hydrophobic Core ◽  
Hydrophobic Membrane ◽  
Simultaneous Exposure ◽  
Significant Group ◽  
Highly Hydrophobic

The water environment determines the activity of biological processes. The role of such an environment interpreted in the form of an external field expressed by the 3D Gaussian distribution in the fuzzy oil drop model directs the folding process towards the generation of a centrally located hydrophobic core with the simultaneous exposure of polar residues on the surface. In addition to proteins soluble in the water environment, there is a significant group of membrane proteins that act as receptors or channels, including ion channels in particular. The change of the polar (water) environment into a highly hydrophobic (membrane) environment is quite radical, resulting in a different hydrophobicity distribution within the membrane protein. Modification of the notation of the force field expressing the presence of the hydrophobic environment has been proposed in this work. A modified fuzzy oil drop model with its adaptation to membrane proteins was used to interpret the structure of membrane proteins–mechanosensitive channel. The modified model was also used to describe the so-called negative cases—i.e., for water-soluble proteins with a clear distribution consistent with the fuzzy oil drop model.

scholarly journals Novel Composite Nanocarriers

2020 ◽  
pp. 1-4
Author(s):  
Ignác Capek ◽  
Ignác Capek
Keyword(s):  
Drug Delivery ◽  
Functional Groups ◽  
Cell Lines ◽  
Cancer Cell ◽  
Colloidal Stability ◽  
Covalent Immobilization ◽  
Hydrophobic Core ◽  
Physiochemical Properties ◽  
Whole Cells ◽  
Hydrophilic Shell

Need for materials with high biocompatible properties have led to the development of prodrug-decorated nanoparticles. The structure of present nanostructures consists of the hydrophobic core and hydrophilic shell. The shell acts as an external envelop which enhances the colloidal stability of dispersion which protects the prodrug of the nanoparticles from photo- and thermal-initiated degradation. The composite nanoparticles coated by organic shells with functional groups were considered to govern the covalent immobilization of therapeutics/biomolecules. The nanoparticles with unique physiochemical properties may be useful as biosensors in living whole cells. The enhanced cellular drug delivery to cancer cell lines via nanoconjugates revealed that smart nanoparticles are an effective tool for transporting and delivering drugs.

Sign in / Sign up

Export Citation Format

Share Document