Hydrophobic core–hydrophilic shell-structured catalysts: a general strategy for improving the reaction rate in water

2012 ◽  
Vol 48 (91) ◽  
pp. 11217 ◽  
Author(s):  
Hengquan Yang ◽  
Xuan Jiao ◽  
Shuru Li
Keyword(s):  
Reaction Rate ◽  
General Strategy ◽  
Hydrophobic Core ◽  
Structured Catalysts ◽  
Hydrophilic Shell

scholarly journals The behavior of hydrophobic-core/hydrophilic-shell structured microgels at an interface: from Mickering emulsion to colloidosomes with dual-level controlled permeability

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95067-95072 ◽  
Author(s):  
Yi Gong ◽  
Mao Wang ◽  
Jianying He
Keyword(s):  
Hydrophobic Core ◽  
Coarse Level ◽  
Controllable Release ◽  
Model Drug ◽  
Hydrophilic Shell

The release of model drug FITC-Dex from colloidosomes was examined in selected media and the controllable release was achieved by adjusting the pH (coarse level) and the ratio of the shell to core in the microgels (fine level).

scholarly journals Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

2018 ◽  
Vol 10 (7) ◽  
pp. 642-658 ◽  
Author(s):  
Ruolin Du ◽  
Yazhou Wang ◽  
Yuhua Huang ◽  
Yinping Zhao ◽  
Dechuan Zhang ◽  
...  
Keyword(s):  
Drug Eluting Stent ◽  
Hydrophobic Core ◽  
Micro Particles ◽  
Drug Eluting ◽  
Stent Coating ◽  
Design And Testing ◽  
Hydrophilic Shell

Hydrophobic Core/Hydrophilic Shell Amphiphilic Particles

2001 ◽  
Vol 238 (2) ◽  
pp. 414-419 ◽  
Author(s):  
Yang Yun ◽  
Hangquan Li ◽  
Eli Ruckenstein
Keyword(s):  
Hydrophobic Core ◽  
Amphiphilic Particles ◽  
Hydrophilic Shell

scholarly journals Novel Composite Nanocarriers

2020 ◽  
pp. 1-4
Author(s):  
Ignác Capek ◽  
Ignác Capek
Keyword(s):  
Drug Delivery ◽  
Functional Groups ◽  
Cell Lines ◽  
Cancer Cell ◽  
Colloidal Stability ◽  
Covalent Immobilization ◽  
Hydrophobic Core ◽  
Physiochemical Properties ◽  
Whole Cells ◽  
Hydrophilic Shell

Need for materials with high biocompatible properties have led to the development of prodrug-decorated nanoparticles. The structure of present nanostructures consists of the hydrophobic core and hydrophilic shell. The shell acts as an external envelop which enhances the colloidal stability of dispersion which protects the prodrug of the nanoparticles from photo- and thermal-initiated degradation. The composite nanoparticles coated by organic shells with functional groups were considered to govern the covalent immobilization of therapeutics/biomolecules. The nanoparticles with unique physiochemical properties may be useful as biosensors in living whole cells. The enhanced cellular drug delivery to cancer cell lines via nanoconjugates revealed that smart nanoparticles are an effective tool for transporting and delivering drugs.

More Is Less: Curcumin and Paclitaxel Formulations Using Poly(2-Oxazoline) and Poly(2-Oxazine) Based Amphiphiles Bearing Linear and Branched C9 Side Chains

2018 ◽  
Author(s):  
Michael M. Lübtow ◽  
Larissa Keßler ◽  
Thomas Lorson ◽  
Niklas Gangloff ◽  
Marius Kirsch ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chain ◽  
Side Chains ◽  
General Strategy ◽  
Loading Capacity ◽  
Hydrophobic Core ◽  
Polymer Micelles ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Insoluble Compounds

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation of hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this limitation is to increase the amphiphilic contrast, i.e. to make the hydrophobic core of the micelles more hydrophobic. However, we reported earlier that for poly(2-oxazoline) based amphiphilic triblock copolymers, a minimal amphiphilic contrast is beneficial, which was tentatively attributed to possible side chain crystallization. Here, we revisit this subject in more detail using more hydrophobic side chains that are either linear (nonyl) or branched (3-ethylheptyl), the latter of which should not crystallize. Moreover, we investigate two different backbones within the hydrophobic block, in particular poly(2-oxazoline) and poly(2-oxazine), for the solubilization and co-solubilization of the two highly water insoluble compounds curcumin and paclitaxel. Even though high loading capacities could be achieved for curcumin within poly(2-oxazine) based triblock copolymers, the solubilization capacity of all investigated polymers with longer side chains was significantly lower compared to poly(2-oxazoline)s and poly(2-oxazine)s with shorter side chains. Although the even lower loading capacity for paclitaxel could be somehow attenuated by co-formulating curcumin, this study corroborates that in the case of poly(2-oxazoline) and poly(2-oxazine) based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.</p>

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