scholarly journals Flow Synthesis of (3R)- and (3S)-(E)-1-Iodohexa-1,5-dien-3-ol: Chiral Building Blocks for Natural Product Synthesis

2018 ◽  
Vol 47 (9) ◽  
pp. 1116-1118 ◽  
Author(s):  
Sota Katayama ◽  
Tomoyuki Koge ◽  
Satoko Katsuragi ◽  
Shuji Akai ◽  
Tohru Oishi
Keyword(s):  
Natural Product ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
Flow Synthesis

scholarly journals Catalytic Asymmetric Intramolecular Darzens Reaction of 2-Halomalonate Derivatives

2019 ◽  
Vol 14 (10) ◽  
pp. 1934578X1988440
Author(s):  
Kenichi Kobayashi ◽  
Kosaku Tanaka ◽  
Momoko Suzuki ◽  
Hiroshi Kogen
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Phase Transfer ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
Darzens Reaction ◽  
Phase Transfer Catalysts ◽  
Catalytic Asymmetric

A catalytic asymmetric intramolecular Darzens reaction of 2-halomalonate derivatives was developed for the enantioselective preparation of chiral building blocks for epoxide-containing natural products. Among the screened catalysts, some phase-transfer catalysts gave the desired epoxide in moderate enantioselectivity, albeit in low yield. The epoxide product would be useful as versatile chiral building blocks for natural product synthesis.

Pd0- and/or Pd2+-Promoted Cyclization in cis-Hydrindane Synthesis - Building Blocks for Natural Product Synthesis

Synlett ◽  
1995 ◽  
Vol 1995 (07) ◽  
pp. 761-762 ◽  
Author(s):  
Masahiro Toyota ◽  
Toshihiro Wada ◽  
Masaki Matsuura ◽  
Keiichiro Fukumoto
Keyword(s):  
Natural Product ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
In Cis

Lithium Aldol Reactions of α-Chloroaldehydes Provide Versatile Building Blocks for Natural Product Synthesis

Synthesis ◽  
2011 ◽  
Vol 2011 (12) ◽  
pp. 1946-1953 ◽  
Author(s):  
Robert Britton ◽  
Shira Halperin ◽  
Baldip Kang
Keyword(s):  
Natural Product ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
Aldol Reactions

Vicinal Tricarbonyl Compounds: Versatile Building Blocks for Natural Product Synthesis

Synthesis ◽  
2016 ◽  
Vol 49 (01) ◽  
pp. 17-28 ◽  
Author(s):  
Ulrich Koert ◽  
Lars Selter ◽  
Lukas Zygalski ◽  
Eric Kerste
Keyword(s):  
Natural Product ◽  
Building Blocks ◽  
Natural Product Synthesis

Regioselective N-alkylation of (2-chloroquinolin-3-yl) methanol with N-heterocyclic compounds using the Mitsunobu reagent

2011 ◽  
Vol 65 (3) ◽  
Author(s):  
Selvaraj Roopan ◽  
Fazlur-Rahman Khan ◽  
Jong Jin
Keyword(s):  
Natural Product ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Natural Product Synthesis ◽  
Mitsunobu Reaction ◽  
Reaction Conditions ◽  
Diethyl Azodicarboxylate ◽  
Nitrogen Heterocyclic

AbstractThe Mitsunobu reaction is a well-established fundamental reaction and has been widely applied in organic synthesis. In this paper, under Mitsunobu conditions dehydration proceeds between (2-chloroquinolin-3-yl)methanol and nitrogen heterocyclic compounds such as quinazolinone, pyrimidone, 2-oxoquinoline in dry THF in the presence of triethylamine, triphenylphosphane and diethyl azodicarboxylate to give the corresponding products. As part of our recent research, we attempted to couple two N-heterocyclic compounds under Mitsunobu reaction conditions to provide efficient building blocks for natural product synthesis.

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