scholarly journals Liquid Phase Peptide Synthesis by Fragment Condensation on Soluble Polymer Support. IV. Relative Reactivities ofN-t-Butoxycarbonyl-(Boc)amino Acids and Boc-Oligopeptide Acids in Their Esterification with Soluble Chloromethylated Polystyrene

1980 ◽  
Vol 53 (8) ◽  
pp. 2405-2406 ◽  
Author(s):  
Mitsuaki Narita ◽  
Kazuya Kusano ◽  
Masanori Hirata ◽  
Makoto Okawara
Keyword(s):  
Amino Acids ◽  
Liquid Phase ◽  
Peptide Synthesis ◽  
Polymer Support ◽  
Soluble Polymer ◽  
Fragment Condensation

Liquid-phase parallel synthesis of 2-aryl-5-methoxylcarbonyl-dihydropyrones using soluble polymer support

2005 ◽  
Vol 46 (22) ◽  
pp. 3797-3799 ◽  
Author(s):  
Jun-Ke Wang ◽  
Ying-Xiao Zong ◽  
Hong-Gang An ◽  
Guo-Qing Xue ◽  
Dong-Qing Wu ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Parallel Synthesis ◽  
Polymer Support ◽  
Soluble Polymer

scholarly journals Synthesis of novel conjugates of a saccharide, amino acids, nucleobase and the evaluation of their cell compatibility

2014 ◽  
Vol 10 ◽  
pp. 2406-2413 ◽  
Author(s):  
Dan Yuan ◽  
Xuewen Du ◽  
Junfeng Shi ◽  
Ning Zhou ◽  
Abdulgader Ahmed Baoum ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liquid Phase ◽  
Mammalian Cell ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Facile Synthesis ◽  
Cell Compatibility ◽  
Amidation Reaction ◽  
Multiple Step

This article reports the synthesis of a novel type of conjugate of three fundamental biological build blocks (i.e., saccharide, amino acids, and nucleobase) and their cell compatibility. The facile synthesis starts with the synthesis of nucleobase and saccharide derivatives, then uses solid-phase peptide synthesis (SPPS) to build the peptide segment (Phe-Arg-Gly-Asp or naphthAla-Phe-Arg-Gly-Asp with fully protected groups), and later, an amidation reaction in liquid phase connects these three parts together. The overall yield of these multiple step synthesis is about 34%. Besides exhibiting excellent solubility, these conjugates of saccharide–amino acids–nucleobase (SAN), like the previously reported conjugates of nucleobase–amino acids–saccharide (NAS) and nucleobase–saccharide–amino acids (NSA), are mammalian cell compatible.

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