Liquid-phase peptide synthesis by fragment condensation on soluble polymer support. 7. Influence of polymer support cross-linking on the coupling reactions of large carboxyl-component peptides with polymer-bound amino-component peptides

1985 ◽  
Vol 18 (7) ◽  
pp. 1363-1366 ◽  
Author(s):  
Mitsuaki Narita ◽  
S. Isokawa ◽  
T. Matsuzawa ◽  
T. Miyauchi
Keyword(s):  
Liquid Phase ◽  
Peptide Synthesis ◽  
Polymer Support ◽  
Cross Linking ◽  
Coupling Reactions ◽  
Soluble Polymer ◽  
Fragment Condensation

Liquid-phase parallel synthesis of 2-aryl-5-methoxylcarbonyl-dihydropyrones using soluble polymer support

2005 ◽  
Vol 46 (22) ◽  
pp. 3797-3799 ◽  
Author(s):  
Jun-Ke Wang ◽  
Ying-Xiao Zong ◽  
Hong-Gang An ◽  
Guo-Qing Xue ◽  
Dong-Qing Wu ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Parallel Synthesis ◽  
Polymer Support ◽  
Soluble Polymer

Pd-Catalyzed Functionalization of Aryl Amines on a Soluble Polymer Support

Synlett ◽  
2020 ◽  
Vol 31 (20) ◽  
pp. 2027-2034
Author(s):  
M. Manuel B. Marques ◽  
A. Sofia Santos
Keyword(s):  
Polymer Support ◽  
Coupling Reactions ◽  
Proof Of Concept ◽  
Heck Reactions ◽  
Soluble Polymer ◽  
Cross Coupling Reactions ◽  
Aryl Amines ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Privileged Structures

AbstractHerein we report the use of a soluble polymer support PEG-2000 on Pd-catalyzed reactions to improve the functionalization of aromatic amines and the synthesis of N-heterocycles. Compatibility of metal-catalyzed reactions for assembling privileged structures such as functionalized anilines were studied. PEG-supported anilines were found to be suitable substrates for Pd-catalyzed N-arylation, Sonogashira and Heck reactions. PEGylated substrates were prepared in yields up to 94%. This work consists on a proof of concept on the use of PEGylated anilines on Pd-catalyzed cross-coupling reactions. Indole core was attained in 82% and 62% yields, via two different routes.

scholarly journals Palladium supported on triazolyl-functionalized hypercrosslinked polymers as a recyclable catalyst for Suzuki–Miyaura coupling reactions

RSC Advances ◽  
2020 ◽  
Vol 10 (29) ◽  
pp. 17123-17128 ◽  
Author(s):  
Cijie Liu ◽  
Lijuan Zheng ◽  
Dexuan Xiang ◽  
Shasha Liu ◽  
Wei Xu ◽  
...  
Keyword(s):  
Palladium Catalyst ◽  
Recyclable Catalyst ◽  
Cross Linking ◽  
Coupling Reactions ◽  
Hypercrosslinked Polymers

A novel hypercrosslinked polymer-palladium catalyst was prepared via external cross-linking reactions and applied in Suzuki–Miyaura reactions as a recyclable catalyst, resulting in TON numbers up to 1.66 × 104 and yields reaching 99%.

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