scholarly journals The Kinetics of Substitution Reactions Involving Metal Complexes. IX. Reactions between Copper(II) and Propylenediaminetetraacetatoplumbate(II) and between Lead(II) and Propylenediaminetetraacetatozincate(II)

1967 ◽  
Vol 40 (4) ◽  
pp. 852-856 ◽  
Author(s):  
Hiroshi Ogino ◽  
Nobuyuki Tanaka
Keyword(s):  
Metal Complexes ◽  
Substitution Reactions ◽  
Kinetics Of

NUCLEOPHILIC SUBSTITUTION REACTIONS OF THE CAFFEINE- DERIVED PT(II) AND PD(II) COMPLEXES WITH IMPORTANT BIOMOLECULES

2021 ◽  
Author(s):  
Snežana Jovanović-Stević ◽  
◽  
Jovana Bogojeski ◽  
A. Caković ◽  
B. Petrović
Keyword(s):  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Anticancer Agents ◽  
Platinum Complex ◽  
Antitumor Drugs ◽  
Substitution Reactions ◽  
Antitumor Activities ◽  
First Order ◽  
Kinetics Of ◽  
Improved Characteristics

The application of transition metal complexes as chemotherapeutics has been presented throughout the history. Platinum-based drugs are widely used as anticancer agents with a broad range of antitumor activities. The study of the substitution reactions of metal complexes with nitrogen containing biomolecules can help to develop new antitumor drugs with improved characteristics. Kinetics of the substitution reactions of [Pt(caffeine)2Cl2] and [Pd(caffeine)2Cl2] (caffeine = 1,3,7-trimethylxanthine) complexes with biologically important ligands such as 9-methylguanine (9-MetGua) and guanosine-5’-monophosphate (5’-GMP) were studied by UV-Vis spectrophotometry and by stopped-flow technique. Kinetics measurements were performed under the pseudo-first order conditions at 37 °C and pH = 7.2 (25 mM Hepes buffer) in addition of 50 mM NaCl. The obtained results showed that all substitution reactions undergo the two reaction steps giving the [M(caffeine)2(Nu)2] (M = Pd(II) or Pt(II) and Nu = 5′-GMP or 9-MetGua) as the reaction product. Additionally, [Pd(caffeine)2Cl2] complex was more reactive compared to analogue platinum-complex, while 9-MetGua reacted faster than 5’-GMP.

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