The Kinetics of Substitution Reactions Involving Metal Complexes. II. Effect of Acetate Ions on the Reaction between Copper(II) and Lead-Ethylenediaminetetraacetate Complexes

Nobuyuki Tanaka; Kiyoko Kato

doi:10.1246/bcsj.32.1376

The Kinetics of Substitution Reactions Involving Metal Complexes. II. Effect of Acetate Ions on the Reaction between Copper(II) and Lead-Ethylenediaminetetraacetate Complexes

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.32.1376 ◽

1959 ◽

Vol 32 (12) ◽

pp. 1376-1380 ◽

Cited By ~ 17

Author(s):

Nobuyuki Tanaka ◽

Kiyoko Kato

Keyword(s):

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. III. Reaction between Copper(II) and Zinc-Ethylenediaminetetraacetate Complexes in Aqueous Solutions

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.33.600 ◽

1960 ◽

Vol 33 (5) ◽

pp. 600-604 ◽

Cited By ~ 11

Author(s):

Kiyoko Kato

Keyword(s):

Aqueous Solutions ◽

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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Kinetics of substitution reactions of transition metal complexes in 1,3-dioxolan-2-one + water and 4-methyl-1,3-dioxolan-2-one + water solvent mixtures

Transition Metal Chemistry ◽

10.1007/bf00618829 ◽

1979 ◽

Vol 4 (2) ◽

pp. 77-81 ◽

Cited By ~ 4

Author(s):

Michael J. Blandamer ◽

John Burgess ◽

Stephen J. Hamshere ◽

Fikry M. Mekhail

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Solvent Mixtures ◽

Substitution Reactions ◽

Water Solvent ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. XIII. Reactions of Zinc(II) withmeso-Butylenediaminetetraacetatocobaltatet(II) and with Propylenediaminetetraacetatocobaltate(II)

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.42.1578 ◽

1969 ◽

Vol 42 (6) ◽

pp. 1578-1583 ◽

Cited By ~ 1

Author(s):

Hiroshi Ogino ◽

Toshiyuki Baba ◽

Nobuyuki Tanaka

Keyword(s):

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. VI. Reaction between Lead(II) and Ethylenediaminetetra-acetatocobaltate(II) Complexes in Aqueous Solutions

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.36.67 ◽

1963 ◽

Vol 36 (1) ◽

pp. 67-72 ◽

Cited By ~ 12

Author(s):

Nobuyuki Tanaka ◽

Hisao Osawa ◽

Minoru Kamada

Keyword(s):

Aqueous Solutions ◽

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. X. Reactions of Zinc(II) with Ethylenediaminetetraacetatocobaltate(II) and Trimethylenediaminetetraacetatocobaltate(II)

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.40.857 ◽

1967 ◽

Vol 40 (4) ◽

pp. 857-861 ◽

Cited By ~ 4

Author(s):

Hiroshi Ogino ◽

Nobuyuki Tanaka

Keyword(s):

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. VII. Effect of Acetate Ions on the Reaction between Lead(II) and Zinc-Ethylenediaminetetraacetate Complexes

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.36.175 ◽

1963 ◽

Vol 36 (2) ◽

pp. 175-178 ◽

Cited By ~ 16

Author(s):

Nobuyuki Tanaka ◽

Hiroshi Ogino

Keyword(s):

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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The Kinetics of Substitution Reactions Involving Metal Complexes. V. Reaction between Copper(II) and Ethylenediaminetetraacetatocadmate(II) Complexes in Aqueous Solutions

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.35.1596 ◽

1962 ◽

Vol 35 (9) ◽

pp. 1596-1600 ◽

Cited By ~ 9

Author(s):

Nobuyuki Tanaka ◽

Minoru Kamada

Keyword(s):

Aqueous Solutions ◽

Metal Complexes ◽

Substitution Reactions ◽

Kinetics Of

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NUCLEOPHILIC SUBSTITUTION REACTIONS OF THE CAFFEINE- DERIVED PT(II) AND PD(II) COMPLEXES WITH IMPORTANT BIOMOLECULES

10.46793/iccbi21.383js ◽

2021 ◽

Author(s):

Snežana Jovanović-Stević ◽

◽

Jovana Bogojeski ◽

A. Caković ◽

B. Petrović

Keyword(s):

Metal Complexes ◽

Transition Metal Complexes ◽

Anticancer Agents ◽

Platinum Complex ◽

Antitumor Drugs ◽

Substitution Reactions ◽

Antitumor Activities ◽

First Order ◽

Kinetics Of ◽

Improved Characteristics

The application of transition metal complexes as chemotherapeutics has been presented throughout the history. Platinum-based drugs are widely used as anticancer agents with a broad range of antitumor activities. The study of the substitution reactions of metal complexes with nitrogen containing biomolecules can help to develop new antitumor drugs with improved characteristics. Kinetics of the substitution reactions of [Pt(caffeine)2Cl2] and [Pd(caffeine)2Cl2] (caffeine = 1,3,7-trimethylxanthine) complexes with biologically important ligands such as 9-methylguanine (9-MetGua) and guanosine-5’-monophosphate (5’-GMP) were studied by UV-Vis spectrophotometry and by stopped-flow technique. Kinetics measurements were performed under the pseudo-first order conditions at 37 °C and pH = 7.2 (25 mM Hepes buffer) in addition of 50 mM NaCl. The obtained results showed that all substitution reactions undergo the two reaction steps giving the [M(caffeine)2(Nu)2] (M = Pd(II) or Pt(II) and Nu = 5′-GMP or 9-MetGua) as the reaction product. Additionally, [Pd(caffeine)2Cl2] complex was more reactive compared to analogue platinum-complex, while 9-MetGua reacted faster than 5’-GMP.

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