pH-Responsive Cotton Effects in the d–d Transition Band of Self-Assembling Copper(II) Complexes with a Cholesteryl-Armed Ligand

2017 ◽  
Vol 90 (6) ◽  
pp. 739-745 ◽  
Author(s):  
Takuya Sagami ◽  
Shota Umemoto ◽  
Yuhei O. Tahara ◽  
Makoto Miyata ◽  
Yusuke Yonamine ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Transition Band ◽  
Self Assembling ◽  
Cotton Effects

scholarly journals Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

ACS Omega ◽  
2021 ◽  
Author(s):  
Yinghua Tao ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Kefeng Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Ph Responsive ◽  
Self Assembling

scholarly journals From Micelles to Fibers: Balancing Self-Assembling and Random Coiling Domains in pH-Responsive Silk-Collagen-Like Protein-Based Polymers

2014 ◽  
Vol 15 (9) ◽  
pp. 3349-3357 ◽  
Author(s):  
Lennart H. Beun ◽  
Ingeborg M. Storm ◽  
Marc W. T. Werten ◽  
Frits A. de Wolf ◽  
Martien A. Cohen Stuart ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Self Assembling

scholarly journals Self-Assembling Behavior of pH-Responsive Peptide A6K without End-Capping

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2017
Author(s):  
Peng Zhang ◽  
Fenghuan Wang ◽  
Yuxuan Wang ◽  
Shuangyang Li ◽  
Sai Wen
Keyword(s):  
Self Assembly ◽  
Md Simulation ◽  
Block Structure ◽  
Distribution Model ◽  
Ph Responsive ◽  
Random Coils ◽  
Self Assembling ◽  
C Terminus ◽  
Transmission Electron ◽  
End Capping

A short self-assembly peptide A6K (H2N−AAAAAAK−OH) with unmodified N− and C−terminus was designed, and the charge distribution model of this short peptide at different pH was established by computer simulation. The pH of the solution was adjusted according to the model and the corresponding self-assembled structure was observed using a transmission electron microscope (TEM). As the pH changes, the peptide will assemble into blocks or nanoribbons, which indicates that the A6K peptide is a pH-responsive peptide. Circular dichroism (CD) and molecular dynamics (MD) simulation showed that the block structure was formed by random coils, while the increase in β-turn content contributes to the formation of intact nanoribbons. A reasonable explanation of the self-assembling structure was made according to the electrostatic distribution model and the effect of electrostatic interaction on self-assembly was investigated. This study laid the foundation for further design of nanomaterials based on pH-responsive peptides.

scholarly journals Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes

2015 ◽  
Vol 6 (8) ◽  
pp. 1255-1266 ◽  
Author(s):  
D. D. Lane ◽  
F. Y. Su ◽  
D. Y. Chiu ◽  
S. Srinivasan ◽  
J. T. Wilson ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Ph Responsive ◽  
Self Assembling ◽  
Antibiotic Drugs

pH-responsive endosomalytic brushes capable of spontaneously self-assembling into polymersomes were synthesized by RAFT and the intracellular delivery of antibiotic drugs was investigated.

scholarly journals Synthesis and characterization of pH responsive D-glucosamine based molecular gelators

2014 ◽  
Vol 10 ◽  
pp. 3111-3121 ◽  
Author(s):  
Navneet Goyal ◽  
Hari P R Mangunuru ◽  
Bargav Parikh ◽  
Sonu Shrestha ◽  
Guijun Wang
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Negative Influence ◽  
Low Molecular Weight ◽  
Ph Responsive ◽  
Triggered Release ◽  
Self Assembling ◽  
Potential Applications ◽  
Low Molecular Weight Gelators ◽  
Neutral Conditions

Small molecular gelators are a class of compounds with potential applications for soft biomaterials. Low molecular weight hydrogelators are especially useful for exploring biomedical applications. Previously, we found that 4,6-O-benzylidene acetal protected D-glucose and D-glucosamine are well-suited as building blocks for the construction of low molecular weight gelators. To better understand the scope of D-glucosamine derivatives as gelators, we synthesized and screened a novel class of N-acetylglucosamine derivatives with a p-methoxybenzylidene acetal protective group. This modification did not exert a negative influence on the gelation. On the contrary, it actually enhanced the gelation tendency for many derivatives. The introduction of the additional methoxy group on the phenyl ring led to low molecular weight gelators with a higher pH responsiveness. The resulting gels were stable at neutral pH values but degraded in an acidic environment. The release profiles of naproxen from the pH responsive gels were also analyzed under acidic and neutral conditions. Our findings are useful for the design of novel triggered release self-assembling systems and can provide an insight into the influence of the the structure on gelation.

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

2018 ◽  
Vol 133 ◽  
pp. 176-187 ◽  
Author(s):  
Claudia Tallian ◽  
Alexandra Herrero-Rollett ◽  
Karina Stadler ◽  
Robert Vielnascher ◽  
Karin Wieland ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Ph Responsive ◽  
Self Assembling ◽  
Structural Insights

A water-soluble metal–organic complex array as a multinuclear heterometallic peptide amphiphile that shows unconventional anion dependency in its self-assembly

2016 ◽  
Vol 52 (8) ◽  
pp. 1579-1581 ◽  
Author(s):  
Pradip K. Sukul ◽  
Purnandhu Bose ◽  
Toshiaki Takei ◽  
Omar M. Yaghi ◽  
Ying He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Aqueous Media ◽  
Water Soluble ◽  
Ph Responsive ◽  
Organic Complex ◽  
Peptide Amphiphile ◽  
Short Peptide ◽  
Self Assembling ◽  
Metal Organic Complex ◽  
Metal Organic

Water-soluble metal–organic complex array 1, bearing Ru(ii), Pt(ii) and Rh(iii) complexes at the side residues of the short peptide, exhibits anion and pH-responsive self-assembling behaviours in aqueous media.

pH-responsive, self-assembling nanoparticle from a fullerene-tagged poly(l-glutamic acid) and its superoxide dismutase mimetic property

2006 ◽  
Vol 298 (1) ◽  
pp. 118-123 ◽  
Author(s):  
Nobuyuki Higashi ◽  
Takeshi Shosu ◽  
Tomoyuki Koga ◽  
Masazo Niwa ◽  
Toru Tanigawa
Keyword(s):  
Superoxide Dismutase ◽  
Glutamic Acid ◽  
Ph Responsive ◽  
Self Assembling
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