A water-soluble metal–organic complex array as a multinuclear heterometallic peptide amphiphile that shows unconventional anion dependency in its self-assembly

2016 ◽  
Vol 52 (8) ◽  
pp. 1579-1581 ◽  
Author(s):  
Pradip K. Sukul ◽  
Purnandhu Bose ◽  
Toshiaki Takei ◽  
Omar M. Yaghi ◽  
Ying He ◽  
...  
Keyword(s):  
Self Assembly ◽  
Aqueous Media ◽  
Water Soluble ◽  
Ph Responsive ◽  
Organic Complex ◽  
Peptide Amphiphile ◽  
Short Peptide ◽  
Self Assembling ◽  
Metal Organic Complex ◽  
Metal Organic

Water-soluble metal–organic complex array 1, bearing Ru(ii), Pt(ii) and Rh(iii) complexes at the side residues of the short peptide, exhibits anion and pH-responsive self-assembling behaviours in aqueous media.

scholarly journals Sustained absorption of delamanid from lipid-based formulations as a path to reduced frequency of administration

2020 ◽  
Author(s):  
Gisela Ramirez ◽  
Anna C. Pham ◽  
Andrew J. Clulow ◽  
Malinda Salim ◽  
Adrian Hawley ◽  
...  
Keyword(s):  
Self Assembly ◽  
Aqueous Suspension ◽  
Aqueous Media ◽  
Milk Powder ◽  
Water Soluble ◽  
Selachyl Alcohol ◽  
Self Assembling ◽  
Suspension Formulation ◽  
Poorly Water Soluble ◽  
Reconstituted Milk

Abstract Delamanid is a poorly water-soluble drug currently being used for the treatment of tuberculosis. The high frequency of dosing leads to poor adherence for patients who live in lower economic and nomadic populations. Non-digestible self-assembling lipids as a formulation approach for poorly water-soluble drugs have previously been shown to extend the window of absorption through gastric retention. We hypothesise that this approach could lead to the reduction of dosing frequency for delamanid and thereby has potential to improve adherence. Formulations of delamanid were prepared in selachyl alcohol and phytantriol as non-digestible self-assembling lipid vehicles, and their behaviour was compared with reconstituted milk powder, as a digestible lipid-based formulation, and an aqueous suspension. The self-assembly of selachyl alcohol and phytantriol in aqueous media in the presence of delamanid was studied using small angle X-ray scattering and produced the inverse hexagonal (H2) and inverse bicontinuous cubic (V2) liquid crystal structures, respectively. The times at which maximum delamanid levels in plasma were observed (Tmax) after oral administration of the phytantriol, selachyl alcohol and reconstituted milk powder formulations of delamanid to rats were 27 ± 3, 20 ± 4 and 6.5 ± 1.0 h, respectively, compared with the aqueous suspension formulation with a Tmax of 3.4 ± 1 h, which confirms the hypothesis of an extended duration of absorption after administration in non-digestible self-assembling lipids. The digestion products of the triglycerides in the milk formulation increased the solubilisation of delamanid in the gastrointestinal tract, leading to an increase in exposure compared with the aqueous suspension formulation but did not significantly extend Tmax. Overall, the non-digestible nanostructured lipid formulations extended the duration of absorption of delamanid well beyond that from milk or suspension formulations.

A new cobalt(II) complex nanosheet as an electroactive medium for plasmonic switching on Au nanoparticles

2021 ◽  
Author(s):  
Yurong Liu ◽  
Wenzheng Lu ◽  
Xizhe Cheng ◽  
Jianfang Wang ◽  
Wai-Yeung Raymond Wong
Keyword(s):  
High Stability ◽  
Au Nanoparticles ◽  
Organic Complex ◽  
Metal Organic Complex ◽  
Metal Organic

2D metal-organic complex nanosheets with the merits of high stability and structure tunability are an emerging topic in recent years. To extend the promising ultrathin architectures, a new Co(II) complex...

High-Performance Single-Electron Transistor Based on Metal–Organic Complex of Thiophene: First Principle Study

2017 ◽  
Vol 64 (11) ◽  
pp. 4628-4635 ◽  
Author(s):  
Anu ◽  
Archana Sharma ◽  
Md. Shahzad Khan ◽  
Anurag Srivastava ◽  
Mushahid Husain ◽  
...  
Keyword(s):  
High Performance ◽  
Single Electron ◽  
Single Electron Transistor ◽  
First Principle ◽  
Organic Complex ◽  
Metal Organic Complex ◽  
Metal Organic

A water-soluble biphen[3]arene: synthesis, host–guest complexation, and application in controllable self-assembly and controlled release

2015 ◽  
Vol 51 (20) ◽  
pp. 4188-4191 ◽  
Author(s):  
Jiong Zhou ◽  
Guocan Yu ◽  
Li Shao ◽  
Bin Hua ◽  
Feihe Huang
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Water Soluble ◽  
Ammonium Salts ◽  
Ph Responsive ◽  
Recognition Motif

The first water-soluble biphen[3]arene was synthesized. Its pH-responsive host–guest complexation with secondary ammonium salts in water was investigated. This novel recognition motif was further used in controllable self-assembly and controlled release.

Synthesis, crystal structure, and quantum mechanical studies regarding a new metal–organic complex based on Cd (II)

2021 ◽  
Author(s):  
zohreh razmara ◽  
Fereshteh Shiri ◽  
Pouya Karimi ◽  
Marek Necas
Keyword(s):  
Three Dimensional ◽  
Pentagonal Bipyramid ◽  
Quantum Mechanical ◽  
Water Molecules ◽  
Organic Complex ◽  
Polymeric Networks ◽  
Metal Organic Complex ◽  
Metal Organic ◽  
Coordinated Water ◽  
Mechanical Studies

Abstract A novel metal-organic complex formulated as [Cd (phen)(dipic) (H2O)2]. 3 H2O (phen = 1, 10-phenanthroline; dipic2−= pyridine-2,6-dicarboxylate) has been hydrothermally synthesized at 150°C for 48h. The structure of Cd complex was characterized by elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential thermal analysis (DTA), and single-crystal X-ray diffraction (SC-XRD). The crystal system of Cd complex is monoclinic with space group C 2/c. The pentagonal bipyramid (seven coordinate) around Cd2+ center filled by two terminal water ligands, one 1,10-phenanthroline, and one pyridine-2,6-dicarboxylate anion. Extensive O–H···O hydrogen bonding interactions involving all coordinated water molecules, dipicolinate oxygens, and crystallization water molecules further stabilize the complex units by linking them to form three-dimensional polymeric networks. Indeed, quantum mechanical studies were performed to understand effective factors on stability of the Cd(II) complex.

Three-Dimensional Zn(II) Complex Based on 2-[(1H-Imidazol-1-yl)Methyl]-6-Methyl-1H- Benzimidazole and Aliphatic Carboxylate

2018 ◽  
Vol 42 (11) ◽  
pp. 575-578 ◽  
Author(s):  
Di Cheng ◽  
Ya-Ping Zhang ◽  
Ke Wang ◽  
Xiang-Ru Meng ◽  
Xiao-Fei Li
Keyword(s):  
Crystal Structure ◽  
Succinic Acid ◽  
Three Dimensional ◽  
Organic Complex ◽  
Thermogravimetric Data ◽  
Metal Organic Complex ◽  
Metal Organic

The metal–organic complex {[Zn(immb)(suc)]·H2O}n [immb = 2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole, H2suc = succinic acid] has been prepared and its crystal structure determined. Its fluorescence and thermogravimetric data have also been obtained.

Design, synthesis and nonlinear optical characterization of novel mixed ligand ruthenium metal-organic complex

2020 ◽  
Vol 107 ◽  
pp. 110068
Author(s):  
K.B Manjunatha ◽  
Dileep Ramakrishna ◽  
B.J. Rudresha ◽  
Albin Antony ◽  
P. Poornesh
Keyword(s):  
Nonlinear Optical ◽  
Optical Characterization ◽  
Mixed Ligand ◽  
Organic Complex ◽  
Design Synthesis ◽  
Metal Organic Complex ◽  
Metal Organic

Synthesis and Crystal Structure of a Cadmium(II) Complex with 2-(4΄-Chlorine-Benzoyl)-Benzoic Acid and 1,10-Phenanthroline

2011 ◽  
Vol 339 ◽  
pp. 313-316
Author(s):  
Xiu Mei Li ◽  
Zhi Tao Wang ◽  
Qing Wei Wang
Keyword(s):  
Benzoic Acid ◽  
Room Temperature ◽  
Supramolecular Network ◽  
X Ray Diffraction ◽  
Organic Complex ◽  
Orthorhombic Space Group ◽  
Synthesis And Crystal Structure ◽  
X Ray ◽  
Metal Organic Complex ◽  
Metal Organic

A new metal-organic complex Cd2(cbba)4(phen)2 (Hcbba = 2-(4΄-chlorine-benzoyl)- benzoic acid, phen = 1,10-phenanthroline) 1 has been hydrothermally synthesized and structurally characterized by elemental analysis, IR, fluorescence spectrum and single-crystal X-ray diffraction. The compound crystallizes in orthorhombic, space group Pbcn with a = 12.0976(4), b = 18.0925(6), c = 31.6829(10) Å, V = 6934.6(4) Å3, C80H48Cd2Cl4N4O12, Mr = 1623.82, Dc = 1.555 g/cm3, μ(MoKα) = 0.8365 mm1, F(000) = 3264, Z = 4, the final R = 0.0396 and wR = 0.0960 for 5372 observed reflections (I > 2(I)). It exhibits a 3D supramolecular network through π-π interactions and shows green luminescent property at room temperature.

Phase transition in metal–organic complex trans-PtCl2(PEt3)2 under pressure: insights into the molecular and crystal structure

CrystEngComm ◽  
2018 ◽  
Vol 20 (26) ◽  
pp. 3728-3740 ◽  
Author(s):  
Naini Bajaj ◽  
Himal Bhatt ◽  
K. K. Pandey ◽  
H. K. Poswal ◽  
A. Arya ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Phase Transition ◽  
Hydrogen Bond ◽  
Structural Phase Transition ◽  
Structural Phase ◽  
Molecular And Crystal Structure ◽  
Supramolecular Architecture ◽  
Organic Complex ◽  
Metal Organic Complex ◽  
Metal Organic

Molecular reorientations result in structural phase transition in trans-PtCl2(PEt3)2 under pressure, leading to a hydrogen bond assisted supramolecular architecture.

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