Occult Micrometastases in Axillary Lymph Nodes Predict Subsequent Distant Metastases in Stage I Breast Cancer: A Case-Control Study with 15-Year Follow-Up

2004 ◽  
Vol 11 (6) ◽  
pp. 568-572 ◽  
Author(s):  
Barbara Susnik ◽  
Snjezana Frkovic-Grazio ◽  
Matej Bracko
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Case Control Study ◽  
Distant Metastases ◽  
Case Control ◽  
Stage I ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Control Study

Preoperative Staging of Large Primary Breast Cancer With [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Compared With Conventional Imaging Procedures

2008 ◽  
Vol 26 (29) ◽  
pp. 4746-4751 ◽  
Author(s):  
David Fuster ◽  
Joan Duch ◽  
Pilar Paredes ◽  
Martín Velasco ◽  
Montserrat Muñoz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Sensitivity And Specificity ◽  
Primary Breast Cancer ◽  
Distant Metastases ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Large Primary

Purpose To evaluate the utility of positron emission tomography (PET) and [18F]fluorodeoxyglucose in the initial staging of large primary breast tumors. Patients and Methods This prospective study was approved by the ethics committee, and all patients gave their informed consent before enrollment. Sixty consecutive patients with large (> 3 cm) primary breast cancer diagnosed by clinical examination and breast magnetic resonance imaging (MRI) were entered onto the study. The mean age was 57 ± 13 years. Chest computed tomography (CT), liver ultrasonography, bone scan, and PET/CT were performed in all patients. All findings were histologically confirmed, and/or at least 1 year of follow-up was required. Correlation between parameters was calculated using Pearson's correlation coefficient. P < .05 was considered statistically significant. Results Primary tumor was identified by both PET/CT and MRI in all patients. Multifocal and/or multicentric tumors were found in 19 patients by MRI. Axillary lymph node metastases were found in 20 of 52 patients. Extra-axillary metastatic lymph nodes were also found in three patients. One patient showed an infiltrated lymph node in the contralateral axilla. The sensitivity and specificity for PET/CT to detect axillary lymph nodes metastases were 70% and 100%, respectively. PET/CT diagnosed all extra-axillary lymph nodes. The overall sensitivity and specificity of PET/CT in detecting distant metastases were 100% and 98%, respectively; whereas the sensitivity and specificity of conventional imaging were 60% and 83%, respectively. PET led to a change in the initial staging in 42% of patients. Conclusion PET/CT underestimates locoregional lymph node staging in large primary breast cancer patients. PET/CT is a valuable tool to discard unsuspected extra-axillary lymph nodes and distant metastases.

Treatment of Breast Cancer in Elderly Women: Retrospective Analysis of 111 Wide Lumpectomies Performed in a Day Hospital Regimen between 1982 and 1988

1992 ◽  
Vol 78 (2) ◽  
pp. 111-114 ◽  
Author(s):  
Emanuele Galante ◽  
Annamaria Cerrotta ◽  
Gabriele Martelli ◽  
Ivan Del Prato ◽  
Daniele Moglia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Elderly Women ◽  
Distant Metastases ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Outpatient Basis ◽  
Breast Cancers ◽  
Day Hospital ◽  
Lost To Follow Up

Between 1982 and 1988, 111 elderly women with breast cancer but without clinical involvement of the axillary lymph nodes underwent wide lumpectomy in a Day Hospital regimen at the National Cancer Institute of Milan. The patients ranged in age from 70 to 92 years (median, 79). An adjuvant treatment was carried out in all but 9 cases: tamoxifen only in 84 cases, tamoxifen plus radiotherapy in 6 cases, radiotherapy alone in 12 cases. The median duration of follow-up was 44 months (range, 30–109 months). Four patients (3.6%) were lost to follow-up. In the remaining 107 patients, 10 local-regional relapses (9.1 %) and 7 distant metastases (6.5 %) occurred. Six patients died from the disease, 14 from unrelated conditions. This retrospective study showed that selected elderly patients with breast cancers can be treated successfully under local anesthesia on an outpatient basis. The treatment guarantees local control of the disease, meets the favor of elderly women and consequently improves their quality of life.

A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Oncology ◽  
1997 ◽  
Vol 54 (6) ◽  
pp. 468-474 ◽  
Author(s):  
Shinzaburo Noguchi ◽  
Hiroki Koyama ◽  
Tsutomu Kasugai ◽  
Hideaki Tsukuma ◽  
Naoko Tsuji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Case Control Study ◽  
Distant Metastases ◽  
Breast Conserving Surgery ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Local Recurrences ◽  
Control Study

Oncotype DX® in breast cancer patients: clinical experience, outcome and follow-up—a case–control study

2017 ◽  
Vol 297 (2) ◽  
pp. 443-447 ◽  
Author(s):  
Michelle G. Rath ◽  
Lorenz Uhlmann ◽  
Marita Fiedler ◽  
Joerg Heil ◽  
Michael Golatta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Clinical Experience ◽  
Case Control Study ◽  
Case Control ◽  
Oncotype Dx ◽  
Breast Cancer Patients ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document