A Case-Control Study on Risk Factors for Local Recurrences or Distant Metastases in Breast Cancer Patients Treated with Breast-Conserving Surgery

Oncology ◽  
1997 ◽  
Vol 54 (6) ◽  
pp. 468-474 ◽  
Author(s):  
Shinzaburo Noguchi ◽  
Hiroki Koyama ◽  
Tsutomu Kasugai ◽  
Hideaki Tsukuma ◽  
Naoko Tsuji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Case Control Study ◽  
Distant Metastases ◽  
Breast Conserving Surgery ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Local Recurrences ◽  
Control Study

scholarly journals Development of CNS metastases in breast cancer patients treated with curative intent: a case–control study

CNS Oncology ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. CNS61
Author(s):  
Katherine Chakrabarti ◽  
Leigh K Swartz ◽  
Anoop Gill ◽  
Fang Fang ◽  
Kelley M Kidwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Lymph Node Status ◽  
Breast Cancer Patients ◽  
Cns Metastases ◽  
Curative Intent ◽  
Control Study

Background: The aim of this study was to identify risk factors that may predispose breast cancer patients to the development of CNS metastases. Materials & methods: We conducted a matched case–control study of breast cancer patients treated with surgery with curative intent. A total of 71 cases and 71 controls were analyzed, matched by year of surgery. Results: In our multivariable model, positive lymph node status (odds ratio [OR]: 5.08; CI: 2.04–12.65), the use of neoadjuvant chemotherapy (OR: 6.02; CI: 2.06–17.57) and triple-negative breast cancer (OR: 5.44; CI: 1.99–14.90) were statistically significant predictors of the development of CNS metastases. Conclusion: Women with certain risk factors have an increased odds of developing CNS metastases and evaluation of utility in brain metastases screening should be considered.

A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients

2021 ◽  
Vol 156 ◽  
pp. 127-135
Author(s):  
Sophie C.J. Bosma ◽  
Marlous Hoogstraat ◽  
Erik van Werkhoven ◽  
Michiel de Maaker ◽  
Femke van der Leij ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Young Breast Cancer ◽  
Control Study

scholarly journals Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257704
Author(s):  
Seblework Mekonen ◽  
Mohammedgezali Ibrahim ◽  
Higemengist Astatkie ◽  
Aynalem Abreha
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Organochlorine Pesticides ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Study Results ◽  
Study Participants ◽  
Control Study

Breast cancer (BC) is becoming one of the most prevalent non-infectious disease in low and middle income countries. The steady rise of BC incidence may be related to the different risk factors. Among many, rampant presence of environmental pollutants might be one of the risk factors. Therefore, the aim of this study is to investigate exposure to organochlorine pesticides as a risk factor to breast cancer. A case-control study design was employed among breast cancer patients and non-breast cancer individuals (controls). Blood samples were collected from 100 study participants (50 cases and 50 controls) followed by serum separation, extraction and cleanup using standard analytical procdures. The findings revealed that ten organochlorine pesticides were detected in the serum of the study participants. From the detected organochlorine pesticides, heptachlor was observed at higher concentration for breast cancer patients (6.90±4.37 μg/L) and controls (9.15±3.84 μg/L). Mean serum level of p,p’-DDE, p,p’-DDT, heptachlor, gamma-chlordane, endosulfan, and dibutyl-chlorendate were significantly higher in the serum of breast cancer patients than the controls. From the studied pesticides, p,p’-DDT and gamma-chlordane are significant predictors for BC, while, others are equivocal. A unit increment of the concentration of p,p’-DDT (AOR; 2.03, 95% CI: 1.041–3.969) increased the odds of developing breast cancer by two, while for gamma-chlordane (AOR;3.12, 95% CI; 1.186–8.203) by three. Our study results suggesting that, organochlorines are a risk factors for breast cancer in Ethiopia. Decreasing exposure to such organochlorines might have a significant public health relevance in reducing non-communicable chronic illnesses. Besides, continues monitoring of persistent organic pollutants using body biomarkers is important for disease prevention and device mitigation measures.

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