Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells

2018 ◽  
Author(s):  
Maiko Kitaoka
Keyword(s):  
Stem Cells ◽  
Ribosomal Dna ◽  
Sister Chromatid ◽  
Binding Protein ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Chromatid Segregation ◽  
Male Germline Stem Cells

scholarly journals Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells

2018 ◽  
Author(s):  
George Watase ◽  
Yukiko Yamashita
Keyword(s):  
Stem Cells ◽  
Ribosomal Dna ◽  
Sister Chromatid ◽  
Zinc Finger Protein ◽  
Biological Significance ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Chromatid Segregation ◽  
Male Germline Stem Cells ◽  
Rdna Copy

Although non-random sister chromatid segregation has been proposed to underlie asymmetric cell divisions, the underlying biological significance or mechanisms remained elusive. Here we show that non-random sister chromatid segregation during asymmetric division of Drosophila male germline stem cells is mediated by ribosomal DNA (rDNA) loci, consisting of hundreds of tandemly repeated rDNA units. We identify a novel zinc-finger protein CG2199/Indra that binds to rDNA and control non-random sister chromatid segregation. Our data indicate that non-random sister chromatid segregation may reflect the segregation of sister chromatids with different rDNA copy numbers after unequal sister chromatid exchange to maintain rDNA copy number through generations. To our knowledge, this is the first study to provide mechanistic insights into the mechanism of non-random sister chromatid segregation.

scholarly journals High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells

2015 ◽  
Vol 29 (23) ◽  
pp. 2420-2434 ◽  
Author(s):  
Matthew F. Pech ◽  
Alina Garbuzov ◽  
Kazuteru Hasegawa ◽  
Meena Sukhwani ◽  
Ruixuan J. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Male Germline Stem Cells
Sign in / Sign up

Export Citation Format

Share Document