On Genital Maturity in an Immature Soma

1930 ◽  
Vol 7 (3) ◽  
pp. 248-252
Author(s):  
L. MIRSKAYA ◽  
F. A. E. CREW
Keyword(s):  
Pregnant Woman ◽  
Female Mouse ◽  
Sexual System ◽  
Immature Female ◽  
Precocious Maturity

The precocious maturity of the sexual system of the immature female mouse provoked by the injection of urine from the pregnant woman is not associated with any maturation of the organism as a whole, for coitus in the case of such animals is never followed by pregnancy. The age at which the first litter is produced is undisturbed by this procedure.

A STUDY OF THE ACTION OF MIROESTROL AND OTHER OESTROGENS ON THE REPRODUCTIVE TRACT OF THE IMMATURE FEMALE MOUSE

1960 ◽  
Vol 20 (3) ◽  
pp. 229-235 ◽  
Author(s):  
H. E. H. JONES ◽  
G. S. POPE
Keyword(s):  
Latent Period ◽  
Female Mouse ◽  
Reproductive Tract ◽  
Single Injection ◽  
Route Of Administration ◽  
Uterine Weight ◽  
Immature Female ◽  
Uterine Lumen ◽  
Multiple Doses

SUMMARY 1. Assay of the potency of the recently isolated plant oestrogen, miroestrol, shows that when given subcutaneously in multiple doses it is as potent as oestradiol-17β, and orally more than three times as potent as stilboestrol in producing an increase in uterine weight in the immature female mouse. 2. In the immature female mouse given a single injection of oestrogens, the route of administration influences the magnitude, the latent period, and the duration of the responses in the reproductive tract. In general, the oestrogens act most efficiently on the uterus and vagina when they are given intraperitoneally instead of subcutaneously. It is suggested that this is because there is less chance of absorption rates and metabolism in the animal influencing the oestrogen introduced intraperitoneally. 3. The activity of miroestrol by single injection is described and compared with that of oestriol, oestradiol-17β and stilboestrol. It is at least as effective as oestradiol-17β and stilboestrol in promoting uterine and vaginal growth, and in increasing the amount of fluid which can be expressed from the uterine lumen by gentle pressing.

Estrogen-like Activity in Vegetable Oils and Mill By-products

Science ◽  
1960 ◽  
Vol 131 (3416) ◽  
pp. 1807-1808 ◽  
Author(s):  
A. N. Booth ◽  
E. M. Bickoff ◽  
G. O. Kohler
Keyword(s):  
Vegetable Oils ◽  
Female Mouse ◽  
Mouse Bioassay ◽  
Uterine Weight ◽  
Immature Female ◽  
Bioassay Technique ◽  
By Products

By the immature female mouse bioassay technique, an increased uterine weight was observed when certain vegetable oils were fed or injected. Byproducts from the milling of cereals were also capable of eliciting a uterine response.

The Fine Structure of Rat Granulosa Cell Cultures Correlated with Progestin Secretion

1973 ◽  
Vol 31 ◽  
pp. 552-553
Author(s):  
T. M. Crisp ◽  
F.R. Denys
Keyword(s):  
Fine Structure ◽  
Granulosa Cell ◽  
Cell Cultures ◽  
Single Injection ◽  
Surrounding Medium ◽  
Petri Dish ◽  
Female Rats ◽  
Vaginal Smear ◽  
Immature Female ◽  
Serum Gonadotropin

The purpose of this paper is to present observations on the fine structure of rat granulosa cell cultures grown in the presence of an adenohypophyseal explant and to correlate the morphology of these cells with progestin secretion. Twenty-six day old immature female rats were given a single injection of 5 IU pregnant mares serum gonadotropin (PMS) in order to obtain ovaries with large vesicular follicles. At 66 hrs. post-PMS administration (estrus indicated by vaginal smear cytology), the ovaries were removed and placed in a petri dish containing medium 199 and 100 U penicillin/streptomycin (P/S)/ml. Under a 20X magnification dissecting microscope, some 5-8 vesicular follicles/ovary were punctured and the granulosa cells were expressed into the surrounding medium. The cells were transferred to centrifuge tubes and spun down at 1000 rpm for 5 mins.

The Rh-sensitized pregnant woman

JAMA ◽  
1966 ◽  
Vol 196 (2) ◽  
pp. 171-172
Author(s):  
H. Schulman
Keyword(s):  
Pregnant Woman
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